Evaluation of the adult nervous system in preclinical studies / Mark T. Butt.

Format:

Video

Author/Creator:

Butt, Mark T., author.

Language:

English

Subjects (All):

Drugs--Toxicology.

Drugs.

Drug Evaluation, Preclinical.

Physical Description:

1 videorecording (48 min., 08 sec.)

Place of Publication:

London : Henry Stewart Talks Ltd, 2009.

System Details:

video file

Contents:

Introduction Nervous systems evaluation Looking at the right place The brain is a heterogeneous tissue General toxicology examination of the brain Rules of thumb for sampling Sectioning interval for 60 sections Creating a sectioning scheme Trimming scheme The use of the trimming method Trimming scheme - dog brain Trimming scheme - rodent brain The spinal cord Looking at the right times Each compound has its own cell death peak Rat brain treated with MK801 (1) Rat brain treated with MK801 (2) The role of imaging in toxicology studies Looking in the right way Tissue changes are not created equal Perfusion fixation Neuronal necrosis stains Cupric silver stain Fluoro Jade B stain IBA-1 stain GFAP stain Luxol fast blue vs. classic silver stain Special procedures example Comparison of embedding and staining techniques Examples of high quality samples Longitudinal nerve sections (1) Longitudinal nerve sections (2) Electron micrograph Summary Thank you and acknowledgements.

Notes:

Description based on: online resource; title from PDF information screen (Henry Stewart Talks Business & Management Collection, viewed April 12, 2024).

Retrieved April 12, 2024, from https://hstalks.com/bs/1348/.