Glycopeptide-resistant enterococci / Dr. Neil Woodford.

Format:

Video

Author/Creator:

Woodford, Neil, author.

Series:

Henry Stewart talks

Language:

English

Subjects (All):

Enterococcus.

Physical Description:

1 videorecording (40 min., 32 sec.) : sound, color.

Place of Publication:

London : Henry Stewart Talks Ltd, [2009]

System Details:

video file

Contents:

Introduction

GRE: where it all began

Prevalence of GRE in the UK

GRE bacteraemias, EARSS 2008

Vancomycin resistant enterococci in the US

GRE are a localised problem in the UK

Enterococci as opportunist pathogens

Risk factors for GRE infection

The clinical problem with GRE - mutliresistance

Enterococcus species

Glycopeptide resistance in enterococci

Characteristics of glycopeptide resistance

GRE: primarily E. faecium with VanA

Glycopeptide action and resistance

GRE ... all because of one critical H-bond

Regulation of glycopeptide resistance (VanA)

Cell wall synthesis in GRE

Glycopeptide dependent enterococci

Cell wall synthesis in resistant enterococci

Resistant isolates

PFGE analysis: the "gold standard" method

A national epidemic of GRE in the UK?

Avoparcin and VanA resistance

MLST of 720 E. faecium isolates

Hospital-adapted lineages

Virulence of E. faecalis

Resistance genes and elements

Genetic exchange in enterococci

The van gene clusters of enterococci

Transposons carry van gene clusters

A national epidemic of VanA elements?

VanA elements in the UK

Origins of resistant enterococci affecting humans

Diversity among VanA elements

Transfer of van genes beyond enterococci

VanA MRSA has arrived

Glycopeptide MICs for two VRSA strains

Poor detection of some VRSA

Glycopeptide-intermediate S. aureus (GISA)

Biochemical basis of resistance in GISA

Resistance to new agents: the red queen theory

Quinupristin-dalfopristin vs. enterococci

'Q-D' resistance mechanisms in enterococci

Linezolid resistance in enterococci

Development of linezolid resistance

Linezolid resistance - summary

Daptomycin: a cyclic lipopeptide

Daptomycin: mechanism of action

Daptomycin: resistance issues, E. faecium

Second generation glycopeptides (1)

Vancomycin's and teicoplanin's modes of action

Second generation glycopeptides (2)

In vitro activity vs. enterococci

Telavancin vs. GRE

Potential for a better anti GRE glycopeptide

Epidemiology of GRE

Acknowledgements.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 14, 2024, from https://hstalks.com/bs/1539/.