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Pharmacogenetics / Prof. Ann Daly.

Henry Stewart Biomedical & Life Sciences Collection Available online

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Format:
Video
Author/Creator:
Daly, Prof. Ann, author.
Language:
English
Subjects (All):
Pharmacokinetics.
Physical Description:
1 videorecording (43 min., 29 sec.)
Place of Publication:
London : Henry Stewart Talks Ltd, 2009.
System Details:
video file
Contents:
Introduction
Pharmacogenetics
Pharmacogenomics
Pharmacogenetics: brief history
Specific examples to be considered
Debrisoquine (CYP2D6) polymorphism
Debrisoquine polymorphism: studies on phenotype
Cytochromes P450
Molecular basis of CYP2D6 polymorphism
Poor metabolism and CYP2D6 polymorphisms
Copy number variants in CYP2D6
Number of CYP2D6 genes and nortryptiline
Tamoxifen and CYP2D6
CYP2D6 and codeine
Ultrarapid metabolizers and codeine
CYP2C9
Functional effect of CYP2C9 alleles
Warfarin
Vitamin K cycle
CYP2C9 genotypes and warfarin
Warfarin dose requirement
Vitamin K epoxide reductase
VKORC1 polymorphisms (1)
VKORC1 polymorphisms (2)
CYP2C9/VKORC1 genotype warfarin dose
Warfarin and pharmacogenetics
Association study on warfarin dose requirement
Methyltransferases
Thiopurine S-methyltransferase (TPMT)
TPMT polymorphism (1)
TPMT polymorphism (2)
Idiosyncratic adverse drug reactions
Simvastatin myopathy
Flucloxacillin-induced liver injury
Summary
References.
Notes:
Description based on publisher supplied metadata and other sources.
Retrieved April 12, 2024, from https://hstalks.com/bs/1581/.

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