Fitness and compensation / Dr. Sébastian Gagneux.

Format:

Video

Author/Creator:

Gagneux, Dr. Sébastian, author.

Language:

English

Subjects (All):

Drug Resistance, Microbial.

Physical Description:

1 videorecording (33 min., 36 sec.)

Place of Publication:

London : Henry Stewart Talks Ltd, 2016.

System Details:

video file

Contents:

Introduction

Outline

Concept of Darwinian fitness

The importance of the fitness impact

Predicting the future of drug resistance

Drug resistant bacteria are less fit

Erythromycin resistance

Sulphonamide resistance

Reversal of drug resistance

How to measure fitness?

Competitive fitness assay

The molecular epidemiology approach

Transmission of drug resistant M. tuberculosis

Evolution of drug resistance

Effect of drug resistance mutations

Measuring the fitness impact of drug mutations

Selection of spontaneous drug resistant mutants

Clinical isolates from patients

Rifampicin resistance in M. tuberculusis

Some clinical mutants have no fitness defect

Clinical frequency of rpoB mutations

Isoniazid resistant M. tuberculosis

Virulence effects of KatG mutations

Epidemiological study in San Francisco

Environment effects of fitness measurements

In vitro vs. in vivo fitness

Effect of strain genetic background

In vivo fitness of FQR C. jejuni

Pre-adapted strain families?

Biogeography of M. tuberculosis

Association of Mtb - 'Beijing' with MDR

Compensatory evolution

Experimental evidence

Compensatory evolution in resistant E. coli

Effect of compensation

Compensation is more likely than reversion

Types of compensatory mutations

Environment effects on compensation

Questions for future research

Clinical relevance of compensation

MDR TB and XTR TB

Comparative genomics of different strains

Summary

Acknowledgements.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 12, 2024, from https://hstalks.com/bs/1533/.