Medicinal chemistry strategies in combating antibiotic resistance / Geoffrey D. Coxon.

Format:

Video

Author/Creator:

Coxon, Geoffrey D., author.

Series:

Henry Stewart talks

Language:

English

Subjects (All):

Drug resistance in microorganisms.

Physical Description:

1 streaming video file (37 min., 06 sec.) : sound, color.

Place of Publication:

London : Henry Stewart Talks Ltd, 2009.

System Details:

video file

Contents:

Introduction

Outline

Introduction of resistance

Drug discovery process

Antibiotic resistance - two fundamental questions

Mechanisms of antibiotic action

Mechanisms of antibiotic resistance: efflux pumps

Modification of the antibiotic pharmacophore

Modification of the target structure

Targeting existing therapy and resistance

b-lactamase inhibition combined with antibiotic

Avoiding efflux pump mechanisms

Overcoming modification in the target structure (1)

Overcoming modification in the target structure (2)

Considerations and methods

Factors for consideration: target (genomic) based

Factors for consideration: whole cell based

Target (genomic) based approaches

"HIT" or "lead" discovery approaches

Fragment based drug discovery

HTS vs. fragment based approach

Modelling: ligand and structure known approach

The development of benzoylaminobenzolic acids

Modelling: structure known but ligand unknown

Discovery of bacterial MurD and MurE inhibitors

Modelling: ligand known but structure unknown

Virtual screening efforts

Target (genomic) based approaches: summary

Whole cell (empirical) based approaches

Selection of chemical starting points (1)

Selection of chemical starting points (2)

Discovery of a new class of anti-TB agent (1)

Discovery of a new class of anti-TB agent (2)

Whole cell based approaches: summary

General summary.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 15, 2024, from https://hstalks.com/bs/1549/.