Neuronal-glial chemical transmission mediated by glutamate and ATP / Alexei Verkhratsky.

Format:

Video

Author/Creator:

Verkhratsky, Alexei, author.

Language:

English

Subjects (All):

Adenosine triphosphatase.

Ion channels.

Neural transmission.

Physical Description:

1 online resource (1 streaming video file (42 min.)) : sound, color

Place of Publication:

London : Henry Stewart Talks Ltd, 2011.

System Details:

video file

Contents:

Introduction

Expression of neurotransmitter receptors

Receptor expression patterns in neurons and glia

Astrocyte-neuronal communication via channels

Neurotransmission by glutamate

Ionotropic glutamate receptors

Neurotransmitter receptors in astrocytes

Calcium influx into glia mediated by AMPARs

NMDA receptors in astroglial cells

Glutamate induces a complex current response

NMDA current response is glycine-sensitive

NMDA receptors are magnesium insensitive

Metabotropic receptors

Parallel fiber stimulation triggers Ca signals in glia

Glutamate transporters

Astrocytes - important in glutamate-uptake in CNS

GluT and AMPAR-mediated currents

Glu induces inward current and sodium influx

Glial Glu sensors help control extracellular Glu

ATP - in neuronal-glial networks

ATP-mediated transmission: the beginning

ATP: the primordial signalling molecule

Mechanisms of ATP release in the CNS

ATP release and degradation in the CNS

Exocytotic ATP release from synaptic terminals

Quantal release of ATP from cortical astrocytes

Purinoceptors: an overview

ATP-a universal transmitter (neural-glial network)

ATP receptors in astroglia trigger calcium signals

ATP universal glial transmitter - oligodendrocytes

ATP-induced currents in cortical astrocytes

ATP currents are concentration-dependent

Pharmacology of ATP-induced currents

Subunit composition of the astroglial P2X receptor

Cortical astrocytes express P2X1 & P2X5 subunits

Synaptic stimulation triggers astroglial currents

Glial synaptic currents (GSC) in the neocortex

Ionotropic receptors and GluT mediate GSC

Spontaneous glial synaptic currents

Calcium permeability of astroglial receptors

NMDA, P2X1/5 receptors are calcium permeable

NMDARs/P2X1/5Rs stimulation triggers Ca signals

Ca signals via ionotropic receptors

Astroglial ionotropic receptors are remodelled

In situ recordings from ageing cortical astroglia

GSC relative weight changes with age

Ageing modifies receptor expression in astroglia

Ageing affects ionotropic Ca signalling in astroglia

Effects of intracellular Na elevation

Conclusions.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 18, 2024, from https://hstalks.com/bs/2030/.