Optimal use of the expanded disability status scale for multiple sclerosis morbidity / Mitchell T. Wallin, Kathryn C. Fitzgerald, William J. Culpepper.

Format:

Book

Author/Creator:

Wallin, Mitchell T., author.

Fitzgerald, Kathryn C., author.

Culpepper, William J., author.

Series:

SAGE Research Methods Cases : Medicine and Health.

SAGE Research Methods Cases: Medicine and Health

Language:

English

Subjects (All):

Multiple sclerosis.

Diagnosis.

Physical Description:

1 online resource.

Place of Publication:

London : SAGE Publications Ltd, 2020.

Summary:

The Expanded Disability Status Scale (EDSS) is the most frequently used neurological disability scale in multiple sclerosis (MS). This article reviews how the EDSS has traditionally been applied to clinical studies and explores features of the scale that are rarely used but should be of benefit to assess disease morbidity and mortality. The EDSS is based on a structured neurological examination with scored individual functional systems (FS) that are used to calculate a summary score from 0 to 10. The summary score has been emphasized in clinical MS treatment trials while the rich data contained within the FS scores and temporal aspects of the scale have been largely neglected. We argue that the EDSS contains a rich and largely unexplored MS phenotypic portrait that is not tied to the ambulation abilities emphasized in the overall summary score. Scales related to the EDSS including the MS Severity Scale and the Patient Determined Disease Steps are also reviewed. New statistical models are highlighted that allow exploration of the unique features of EDSS over time. This research project is aimed provide a more complete understanding of the utility of the EDSS for future MS research.

Notes:

Includes bibliographical references and index.

Description based on XML content.

ISBN:

1-5297-3584-X

9781529735840

OCLC:

1151030962