Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer : From Molecular Insights to Precision Solutions / Zodwa Dlamini, editor.

Format:

Book

Contributor:

Dlamini, Zodwa, editor.

Series:

Cancer sensitizing agents for chemotherapy ; Volume 21.

Cancer Sensitizing Agents for Chemotherapy ; Volume 21

Language:

English

Subjects (All):

Cervix uteri--Cancer.

Cervix uteri.

Drug resistance in cancer cells.

Physical Description:

1 online resource (218 pages)

Edition:

First edition.

Place of Publication:

London, England : Academic Press, [2024]

Summary:

Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer: From Molecular Insights to Precision Solutions, Volume 21 highlights different strategies to reverse chemotherapy resistance in cervical cancer. The book puts a strong focus on strategies to reverse chemotherapy resistance as well as strategies for early detection of the resistance, enhancing precision oncology in terms of patient care and maximizing patient management. The book also looks at virally induced resistance to chemotherapy and recommends combination therapies that can maximize the reversal of this resistance.In 10 chapters, the book not only gives an overview of cervical cancer and chemotherapy as treatment, but also investigates resistance to chemotherapy and treatment for resistance. It defines treatment mechanisms, options, and limitations to beat chemotherapy resistance and the reversal of the resistance mechanisms. It gives insights into future directions of cervical cancer treatment using epigenetic silencing, chemotherapy splicing, the involvement of MicroRNAs to chemotherapy resistance, and the application of Artificial Intelligence.- Discusses strategies to reverse and detect resistance to chemotherapy at an early stage- Investigates the applications of Artificial Intelligence in the study of cervical chemotherapy resistance- Presents research and applications developed to overcome cancer resistance

Contents:

Intro

Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer: From Molecular Insights to Precision Solutions

Copyright

Cover Image Legend

Aims and Scope for Series ``Cancer Sensitizing Agents for Chemotherapy´´

About the Series Editor

Aims and Scope of the Volume

About the Volume Editor

Preface

Contents

Contributors

Chapter 1: An overview of cervical cancer, chemotherapy as treatment and chemotherapy resistance

Introduction

Staging for cervical cancer

The role of chemotherapy in the treatment of cervical cancer

Mode of action: Cisplatinum

The role of immunotherapy in the treatment of cervical cancer

Mode of action: Immunotherapy

Understanding the pathway for chemotherapy resistance

DNA methylation

Aberrant repair pathways

Stemness

Tumor microenvironment

Hypoxia

Classification of cisplatin resistance

Pretarget resistance

On-target resistance

Posttarget resistance

Off-target resistance

Overcoming chemotherapy resistance for future management of cervical cancer

Epigenetic regulators, and molecular therapies

Natural products from plants, and bioactive metabolites from micro-organisms used to overcome cancer resistance

Challenges for overcoming chemotherapy resistance in cervical cancer

Conclusion

References

Chapter 2: Current treatment options and limitations for cervical cancer

Introduction-Current approach to cervical cancer therapies

Chemotherapy regimens and their effectiveness

Targeted therapies and immunotherapies

Combination therapies and clinical trials

Limitations of current treatment options

Conclusions

Chapter 3: Radiotherapy treatment resistance in cervical cancer

Conventional clinical-pathological factors

Patient-related factors

Treatment-related factors.

Tumor-related factors

Genomic markers of lymph node metastases

Pathological tumor type and treatment resistance

HPV and treatment resistance

HPV subtype

HPV viral load

HPV integration

Tumor hypoxia

Genetic alterations associated with treatment response

Limitations

Chapter 4: Mechanisms of chemotherapy resistance in cervical cancer

Background

The tumor microenvironment (TME) as an enabling environment in CC chemoresistance

Cancer stem cell activation

Cancer associated fibroblasts (CAFs) and immune cells

Tumor hypoxia in chemoresistance

Signaling pathways and epigenetics in CC chemoresistance

P53 pathway

PIP3K/Akt/MAPK pathway

EGFR pathway

Hippo pathway

SH3BP1 pathway

Metabolic alterations in chemoresistance

Combinatorial therapies in overcoming CC

Limitations and challenges of targeting cellular and molecular mechanisms in CC chemoresistance

Chapter 5: Reversal of resistance mechanisms in cervical cancer

Identification of resistance mechanisms

Reduced uptake

Increased efflux

Thiol-containing protein-mediated inactivation

Increased DNA repair

Nucleotide excision repair

DNA mismatch repair

Inactivation of apoptosis pathways

Activation of EMT

Epigenetic factors

Stress response chaperones

Development of novel drugs and methods to target resistance mechanisms

Novel drugs for cervical cancer treatment

Overcoming resistance by drug delivery mechanisms

Liposomes

Hydrogels

Nanoparticles

Repurposing of existing drugs

Combination therapies to overcome resistance

Chapter 6: HPV- and HIV-associated epigenetic silencing in cervical cancer: Targets for overcoming chemoresistance

HPV, HIV, and cervical cancer.

Mechanisms of HPV/HIV interaction in cervical cancer at a molecular level

HPV/host epigenetic modifications leading to chemoresistance in cervical cancer

DNA methylation and chemoresistance in cervical cancer

HPV genome methylation

Host genome methylation

Host methylation of apoptosis-associated genes

Host methylation of cell cycle-associated genes

DNA methylation of cell adhesion-associated genes

DNA methylation of cell differentiation and proliferation-associated genes

DNA methylation of DNA repair-associated genes

DNA methylation of cell signaling-associated genes

Histone acetylation

HPV histone acetylation

Host histone acetylation

Potential epigenetic biomarkers for cervical cancer treatment

Challenges and limitations of epigenetic biomarkers for cervical cancer treatment

Conclusion and future perspective

Chapter 7: Splicing-associated chemotherapy resistance in cervical cancer: Targeting splicing signatures

Alternative splicing as a normal biological process

Dysregulated alternative splicing in cervical neoplasia and alterations in splicing regulatory factors

Alterations in splicing factors in CC

Alterations in hnRPNs in CC

Splicing and chemoresistance in CC

Deregulation of splicing factors leads to chemotherapy resistance in CC

CeRNA networks promote chemoresistance through alternative splicing regulation

LncRNAs splicing switch in CC chemoresistance

CircRNAs splicing switch in CC chemoresistance

siRNAs splicing switch in CC chemoresistance

PiRNAs splicing switch in CC chemoresistance

Limitations and challenges of targeting splicing signatures in alleviating CC chemoresistance

References.

Chapter 8: MicroRNA involvement in cervical cancer chemotherapy drug resistance: Restoring sensitivity to chemotherapeuti ...

MicroRNAs-The potential cervical cancer treatment

Chemotherapy resistance and sensitivity

Application of miRNA in diagnosis and prognosis of cervical cancer

Challenges and limitations

Chapter 9: Future directions in cervical cancer treatment

The roadmap to elimination of cervical cancer by 2030

Personalized medicine and precision oncology

Nanocarrier and drug-based delivery systems

Radiopharmaceutical therapy

Computational oncology

Artificial intelligence

Computational intelligence

Molecular targeted therapies

Monoclonal antibodies

Gene therapy

Indigenous knowledge systems

Identification of biomarkers for resistance

Chapter 10: Conclusion: Overcoming chemoresistance in cervical cancer

Index.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Other Format:

Print version: Dlamini, Zodwa Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer

ISBN:

9780443289866

0443289867

OCLC:

1419872496