In Silico Dreams : how artificial intelligence and biotechnology will create the medicines of the future / Brian Hilbush.

Format:

Book

Author/Creator:

Hilbush, Brian, author.

Language:

English

Subjects (All):

Drug development.

Pharmaceutical biotechnology.

Artificial intelligence--Medical applications.

Artificial intelligence.

Physical Description:

1 online resource (350 pages)

Place of Publication:

Hoboken, New Jersey : John Wiley and Sons, [2021]

Summary:

Learn how AI and data science are upending the worlds of biology and medicine In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future delivers an illuminating and fresh perspective on the convergence of two powerful technologies: AI and biotech. Accomplished genomics expert, executive, and author Brian Hilbush offers readers a brilliant exploration of the most current work of pioneering tech giants and biotechnology startups who have already started disrupting healthcare. The book provides an in-depth understanding of the sources of innovation that are driving the shift in the pharmaceutical industry away from serendipitous therapeutic discovery and toward engineered medicines and curative therapies. In this fascinating book, you'll discover: * An overview of the rise of data science methods and the paradigm shift in biology that led to the in silico revolution * An outline of the fundamental breakthroughs in AI and deep learning and their applications across medicine * A compelling argument for the notion that AI and biotechnology tools will rapidly accelerate the development of therapeutics * A summary of innovative breakthroughs in biotechnology with a focus on gene editing and cell reprogramming technologies for therapeutic development * A guide to the startup landscape in AI in medicine, revealing where investments are poised to shape the innovation base for the pharmaceutical industry Perfect for anyone with an interest in scientific topics and technology, In Silico Dreams also belongs on the bookshelves of decision-makers in a wide range of industries, including healthcare, technology, venture capital, and government.

Contents:

Cover

Title Page

Copyright Page

About the Author

About the Technical Editor

Acknowledgments

Contents at a Glance

Contents

Introduction

What Does This Book Cover?

Reader Support for This Book

Chapter 1 The Information Revolution's Impact on Biology

A Biological Data Avalanche at Warp Speed

Tracking SARS-CoV-2 with Genomic Epidemiology

Biology's Paradigm Shift Enables In Silico Biology

Transitions and Computation in Cancer Research

Structural Biology and Genomics

Sequencing the Human Genome

Computational Biology in the Twenty-First Century; Applications of Human Genome Sequencing

Analyzing Human Genome Sequence Information

Omics Technologies and Systems Biology

Notes

Chapter 2 A New Era of Artificial Intelligence

AI Steps Out of the Bronx

From Neurons and Cats Brains to Neural Networks

Machine Learning and the Deep Learning Breakthrough

Deep Learning Arrives for AI

Deep Neural Network Architectures

Deep Learning's Beachhead on Medicine: Medical Imaging

Limitations on Artificial Intelligence

Recommended Reading

Chapter 3 The Long Road to New Medicines; Medicine's Origins: The Role of Opium Since the Stone Age

Industrial Manufacturing of Medicines

Paul Ehrlich and the Birth of Chemotherapeutic Drug Discovery

The Pharmaceutical Industry: Drugs and War-New Medicines in the Twentieth Century

From Synthetic Antibiotics to the Search for New Drugs from the Microbial World

Developing Therapeutics for Cancer

Antifolates and the Emergence of DNA Synthesis Inhibitors

Antibiotics as Cancer Chemotherapeutic Drugs

Immunotherapy

The Pharmaceutical Business Model in the Twenty-First Century; R&D Productivity Challenges Within the Pharmaceutical Industry

Sources of Pharmaceutical Innovation: Biotechnology and New Therapeutic Modalities

Chapter 4 Gene Editing and the New Tools of Biotechnology

Molecular Biology and Biological Information Flow

Manipulating Gene Information with Recombinant DNA Technology

Genetics, Gene Discovery, and Drugs for Rare Human Diseases

Second-Generation Biotechnology Tools: CRISPR- Cas9 and Genome Editing Technologies

Human Genome Editing and Clinical Trials; Biotechnology to the Rescue: Vaccine Development Platforms Based on Messenger RNA

Chapter 5 Healthcare and the Entrance of the Technology Titans

Digital Health and the New Healthcare Investment Arena

Assessing the Tech Titans as Disruptors in Healthcare

Alphabet: Extending Its Tentacles Into Healthcare with Google and Other Bets

Apple Inc: Consumer Technology Meets Healthcare

Amazon: Taking Logistics to the Next Level for Delivering Healthcare

Echoes of the Final Frontier

Chapter 6 AI-Based Algorithms in Biology and Medicine

Recognizing the Faces of Cancer

Tumor Classification Using Deep Learning with Genomic Features

AI for Diseases of the Nervous System: Seeing and Changing the Brain

Regulatory Approval and Clinical Implementation: Twin Challenges for AI-Based Algorithms in Medicine

Chapter 7 AI in Drug Discovery and Development

A Brief Survey of In Silico Methods in Drug Discovery

Virtual Screening with Cheminformatics and HTS Technologies

AI Brings a New Toolset for Computational Drug Design

AI-Based Virtual Screening Tools

Generative Models for De Novo Drug Design

A New Base of Innovation for the Pharmaceutical Industry

Atomwise

Recursion Pharmaceuticals

Deep Genomics

Relay Therapeutics

Summary

Notes. Chapter 8 Biotechnology, AI, and Medicine's Future

Building Tools to Decipher Molecular Structures and Biological Systems

AlphaFold: Going Deep in Protein Structure Prediction

Predicting Genome 3D Organization and Regulatory Elements

AI Approaches to Link Genetics-Based Targets to Disease

Quantum Computing for In Silico Chemistry and Biology

Neuroscience and AI: Modeling Brain and Behavior

Brain Information Processing and Modularity: Climbing a Granite Wall

Engineering Medicines with Biotechnology and AI

Glossary

Index

EULA.

Notes:

Includes index.

Description based on print version record.

ISBN:

9781119745631

1119745632

9781119745648

1119745640

OCLC:

1263026880