Malformations of the nervous system / volume editors, Harvey B. Sarnat and Paolo Curatolo.

Format:

Book

Contributor:

Sarnat, Harvey B.

Curatolo, Paolo.

Series:

Handbook of clinical neurology ; 0072-9752 3rd ser., v. 87.

Handbook of clinical neurology ; 3rd ser., v. 87

Language:

English

Subjects (All):

Nervous system--Abnormalities.

Nervous system.

Nervous System Malformations.

Nervous System--embryology.

Medical Subjects:

Nervous System Malformations.

Nervous System--embryology.

Physical Description:

1 online resource (xv, 644 pages, 28 unnumbered pages of plates) : illustrations (some color)

Place of Publication:

Edinburgh ; New York : Elsevier, 2008.

Language Note:

English.

Summary:

'Malformations of the Nervous System' describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

Contents:

Front Cover; Malformations of the Nervous System; Copyright Page; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; List of contributors; Contents; Section I: Specific malformations using the new integrative classification; Revised classification; Chapter 1: Axes and gradients of the neural tube for a morphological/molecular genetic classification of nervous system malformations; 1.1.1. Axes of the neural tube and gradients of genetic expression; 1.2. Upregulation/downregulation versus overexpression/underexpression; 1.3.1. Longitudinal axis

1.6. Scheme of classification of central nervous system malformations1.7. Conclusions; Midline hypoplasias; Chapter 2: Holoprosencephaly; 2.3.5. Newer classification schema; 2.4.2. Genetic causes; 2.4.4. Nodal/TGFbeta pathway; 2.4.5. Other gene mutations; 2.4.6. Genotype-phenotype correlation; 2.4.7. Environmental causes; 2.5.2. Midline dorsal cyst; 2.5.3. Cortical gyral abnormalities; 2.5.4. White matter abnormalities; 2.5.5. Other cerebral anomalies; 2.5.7. Middle interhemispheric variant; 2.5.8. Neuroimaging technical approaches; 2.5.9. Fetal neuroimaging; 2.7. Clinical manifestations

2.7.1. Craniofacial anomalies2.7.2. Developmental dysfunction and behavior; 2.7.3. Seizures and epilepsy; 2.7.4. Endocrinopathies; 2.7.5. Temperature dysregulation; 2.7.6. Microcephaly; 2.7.7. Dorsal cyst and hydrocephalus; 2.7.8. Motor dysfunction; 2.8. Conclusion; Chapter 3: Septo-optic-pituitary dysplasia; 3.4.2. The identification of relevant cerebral anomalies; Chapter 4: Rhombencephalosynapsis; 4.3. The confines of rhombencephalosynapsis defined by neuroimaging; 4.4.6. Holoprosencephaly; 4.4.8. Neocortical dysplasia; 4.7. Inherited disorders

Chapter 5: Embryology and malformations of the forebrain commissures5.7. Genetics of callosal agenesis; 5.9.4. Hemimegalencephaly; 5.9.8. Association of callosal agenesis with metabolic diseases; Disorders of segmentation of the neural tube; Chapter 6: Disorders of segmentation of the neural tube: Chiari malformations; 6.3.3. Hydromyelia and aqueductal atresia in Chiari malformations; 6.7. Historical note; Chapter 7: Disorders of segmentation of the neural tube: agenesis of selective neuromeres; 7.3. Agenesis of isolated neuromeres; Chapter 8: Cerebellar hypoplasias

8.1.6. Classification of cerebellar malformations8.4.2. Cerebello-oculo-renal and related syndromes; Hamartomatous disorders of cellular lineage; Chapter 9: Tuberous sclerosis; 9.3. Molecular genetics; 9.4.3. Genotype/phenotype correlations; 9.6.4. Lungs; 9.7. Treatment; Chapter 10: Hemimegalencephaly syndrome; 10.3. Pathogenesis of neurocutaneous syndromes; 10.3.1. Classification; 10.7. Associated hemimegalencephaly; 10.7.1. With neurocutaneous syndromes; 10.8.1. Imaging features; References; Disorders of radial neuroblast migration and cerebral cortical architecture

Notes:

Includes bibliographical references and index.

Print version record.

Other Format:

Print version: Malformations of the nervous system.

ISBN:

9780080559841

0080559840

9786613921833

6613921831

OCLC:

228147897

Access Restriction:

Restricted for use by site license.