The heart in systemic autoimmune diseases / edited by Fabiola Atzeni, Andrea Doria, Michael Nurmohamed, Paolo Pauletto.

Format:

Book

Contributor:

Atzeni, Fabiola, editor.

Doria, A. (Andrea), editor.

Nurmohamed, Mike, editor.

Pauletto, Paolo, 1947- editor.

Series:

Handbook of systemic autoimmune diseases ; v. 14.

Handbook of systemic autoimmune diseases ; volume 14

Language:

English

Subjects (All):

Heart--Diseases--Immunological aspects--Handbooks, manuals, etc.

Heart.

Autoimmune diseases--Handbooks, manuals, etc.

Autoimmune diseases.

Cardiological manifestations of general diseases--Handbooks, manuals, etc.

Cardiological manifestations of general diseases.

Atherosclerosis--Immunological aspects--Handbooks, manuals, etc.

Atherosclerosis.

Vasculitis--Handbooks, manuals, etc.

Vasculitis.

Heart--Immunology--Handbooks, manuals, etc.

Heart Diseases--immunology.

Autoimmune Diseases--complications.

Medical Subjects:

Heart Diseases--immunology.

Atherosclerosis.

Autoimmune Diseases--complications.

Genre:

handbooks.

Handbooks and manuals

Handbooks and manuals.

Physical Description:

1 online resource

Edition:

Second edition.

Place of Publication:

Amsterdam, Netherlands : Elsevier, 2017.

Summary:

This book provides an overview on the current understanding of major complications relating to the heart and autoimmune diseases. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations of these important comortbidities. Mortality in autoimmune diseases, in particular, rheumatoid arthritis and SLE, has increased when compared with the general population, due largely to cardiovascular diseases.

Contents:

Front Cover; The Heart in Systemic Autoimmune Diseases; Handbook of Systemic Autoimmune Diseases; Handbook of Systemic Autoimmune Diseases; Copyright; Dedication; Contents; List of Contributors; Preface; 1

Cellular Immunity: A Role for Cytokines; 1. INTRODUCTION; 2. AUTOIMMUNITY IN MYOCARDITIS; 3. PATHOGENESIS: THE ROLE OF CELLS AND CYTOKINES; 3.1 Viral Mouse Model; 3.2 Cardiac Myosin Mouse Model; 3.3 Role of Cells; 3.4 Role of Cytokines; 3.5 Summary of Pathogenic Mechanisms; REFERENCES; FURTHER READING; 2

Organ-Specific Autoimmunity Involvement in Cardiovascular Disease; 1. INTRODUCTION

7. SYSTEMIC ARTERIAL HYPERTENSION7.1 Anti-Heart Autoantibodies by s-I IFL; 7.2 Stimulating Autoantibodies to α1-Adrenergic Receptors; 7.3 Stimulating Autoantibodies to the Angiotensin Receptor; REFERENCES; 3

Neonatal Lupus Syndromes: Pathogenesis and Clinical Featuresa; 1. INTRODUCTION; 2. EPIDEMIOLOGY AND DEFINITION OF CONGENITAL COMPLETE AVB; 3. ETIOLOGY/PATHOGENESIS; 3.1 Myocarditis; 3.2 Arrhythmogenesis and Electrophysiological Effects; 3.3 Apoptosis, TGFbeta, TLR, and the Road to Scar; 3.4 Genetics; 3.5 Evaluation of the Fine Specificities of the Maternal Autoantibody Profile

2. POST-MYOCARDIAL INFARCTION (DRESSLER) SYNDROME2.1 Anti-Heart Autoantibodies; 3. POST-PERICARDIOTOMY SYNDROME AND IDIOPATHIC RECURRENT ACUTE PERICARDITIS; 3.1 Anti-Heart Autoantibodies; 4. RHEUMATIC CARDITIS; 4.1 Immune Pathogenesis of Rheumatic Carditis; 4.1.1 Antistreptococcus Antibodies; 4.1.2 Anti-heart Autoantibodies; 5. DILATED CARDIOMYOPATHY AND MYOCARDITIS; 5.1 Immune Pathogenesis of Myocarditis and Dilated Cardiomyopathy; 5.2 Anti-Heart Autoantibodies by s-I IFL; 5.3 Anti-Heart Autoantibodies by s-I IFL: Technical Considerations and Proposed Nomenclature

3.6 Other Pathogenetic Mechanisms4. RISK OF DELIVERING A CHILD WITH COMPLETE CHB; 5. CLINICAL MANIFESTATIONS; 5.1 Cardiac Manifestations; 5.2 Non-Cardiac Manifestations; 6. TREATMENT; 6.1 Fluorinated Corticosteroids; 6.2 Other Possible Therapies; 6.3 Postnatal Treatment; 7. OBSTETRIC MANAGEMENT OF PREGNANCIES AT RISK OF DEVELOPING CCHB; 8. PROGNOSIS; 8.1 Infants; 8.2 Maternal; 9. OTHER PREGNANCY OUTCOMES IN WOMEN WITH ANTI-RO/SSA ANTIBODIES; 10. ANTI-RO/SSA NEGATIVE CHB; ACKNOWLEDGMENT; REFERENCES; 4

Subclinical Cardiovascular Damage in Systemic Rheumatic Diseases; 1. INTRODUCTION

5.4 Autoantibodies to Myosin Heavy Chain and Other Autoantigens by Immunoblotting Techniques5.5 Autoantibodies to Sarcolemmal Na-K-ATPase; 5.6 Autoantibodies to Mitochondrial and to Extracellular Matrix Antigens; 5.7 Blocking and Stimulating Autoantibodies to β-Adrenergic Receptors; 5.8 Autoantibodies to M2-Muscarinic Receptors; 5.9 Cardiac-Specific Antibodies in Myocarditis/DCM: Clinical Correlates and Potential Functional Role; 6. IDIOPATHIC TACHY AND BRADYARRHYTHMIAS; 6.1 Cardiac Conducting Tissue Antibodies; 6.2 Stimulating Autoantibodies to β-Adrenergic Receptors

Notes:

Includes index.

Online resource; title from PDF title page (ScienceDirect, viewed February 17, 2017).

Other Format:

Print version: Heart in systemic autoimmune diseases.

ISBN:

9780444636690

0444636692

OCLC:

972734329

Access Restriction:

Restricted for use by site license.