1 option
Medical Immunology / edited by Gabriel Virella.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Clinical immunology.
- Immunology.
- Immune System Phenomena.
- Immune System Diseases.
- Medical Subjects:
- Immune System Phenomena.
- Immune System Diseases.
- Physical Description:
- 1 online resource (xvi, 462 pages) : colour illustrations
- Edition:
- Seventh edition.
- Place of Publication:
- Boca Raton, FL : CRC Press, 2020.
- Summary:
- This new edition of Medical Immunology provides a brief clinical review of human response to infection. Emphasizing on clinical applications, methodological advances, immunological diseases,and innovative interventions, this guide navigates readers through technologies and demonstrates their implementation in daily clinical practice of immunology.
- Contents:
- Cover
- Half Title
- Title Page
- Copyright Page
- Dedication
- Contents
- Preface
- Acknowledgments
- Editor
- Contributors
- 1. Introduction
- Historical overview
- General concepts
- Cells of immune system
- Antigens and antibodies
- Lymphocytes and cell-mediated immunity
- Self versus non-self keep non-self discrimination
- General overview
- Immunology and medicine
- 2. Leukocytes and lymphoid tissues: The framework of the immune system
- Introduction
- Lymphoid organs and tissues
- Lymphocyte traffic
- Bibliography
- 3. Major histocompatibility complex
- Major histocompatibility complex genes
- MHC protein structure
- MHC protein functions
- HLA disease associations
- 4. Adaptive immune response: Antigens, lymphocytes, and accessory cells
- Antigenicity and immunogenicity
- Activation of humoral immune system
- T-dependent and T-independent antigens
- Induction of immune response
- 5. Immunoglobulins: Structure and diversity
- Structure of immunoglobulin G
- Structural and antigenic heterogeneity of heavy and light chains
- Immunoglobulin regions and domains
- Antibody-combining site
- Immunoglobulin M: A polymeric molecule
- Immunoglobulin A: A molecularly heterogeneous immunoglobulin
- Minor immunoglobulin classes: IgD and IgE
- 6. Immunoglobulins: Metabolism and biological properties
- Immunoglobulin biosynthesis
- Immunoglobulin synthetic and catabolic rates
- Biological properties of immunoglobulins
- 7. Genetics of immunoglobulins: Ontogenic, biological, and clinical implications
- Immunoglobulin gene rearrangement
- Genetic basis of antibody diversity
- Antigenic determinants of immunoglobulin molecules
- Allelic exclusion.
- GM allotypes and Igg subclass concentrations
- Immunoglobulin allotypes, immune response, and diseases
- 8. Antigen-antibody reactions
- General characteristics of the antigen-antibody reaction
- Specific types of antigen-antibody reactions
- Biological consequences of the antigen-antibody reaction
- 9. The complement system in health and disease
- Complement activation mechanisms and pathways
- Alternative complement pathway
- Lectin pathway of complement activation
- Late steps of complement activation
- Complement receptors
- Regulation of complement activation
- Functions of the complement system
- Complement and disease
- Complement levels in disease
- Microbial anticomplementary mechanisms
- 10. Monocyte and lymphocyte membrane markers: Ontogeny and clinical significance
- Hematopoietic stem cells
- Monocytes
- Dendritic cells
- Lymphocytes
- NK-cell inhibitory markers
- Unconventional T cells
- T lymphocyte markers
- B cells
- 11. Cell-mediated immunity
- T-cell activation
- Immune memory
- Regulation of the immune response
- Concluding remarks
- 12. Adaptive humoral immunity and immunoprophylaxis
- Overview of induction of humoral immune response
- Primary immune response
- Secondary or anamnestic response
- Fate of antigens on primary and secondary responses
- Mucosal humoral immune response
- Passive immunization
- Immunoprophylaxis
- 13. Phagocytic cells and their functions
- Physiology of polymorphonuclear leukocytes
- Physiology of monocyte/macrophage
- Phagocytic cell activation and inflammation
- Laboratory evaluation of phagocytic function
- 14. Anti-infectious innate and adaptive immune responses.
- Introduction
- Innate immunity
- Natural antibodies
- Adaptive immunity
- Immune deficiency syndromes for study of immune defenses against human infections
- Escape from immune response
- Abnormal consequences of the immune response
- Epilogue
- 15. Diagnostic applications of immunology
- Serological assays
- Classical assays
- Tests based on Immunofluorescence
- Monoclonal antibody-based assays
- Flow cytometry
- Cell isolation
- Immunohistochemistry
- Highly sensitive immunoassays
- Enzyme immunoassay
- Evaluation of cellular immune responses
- Laboratory tests for assessment of lymphocyte function ex vivo
- Laboratory tests for assessment of lymphocyte function in vivo
- Laboratory tests for assessment of phagocytic cell function
- 16. Tolerance and autoimmunity
- Definition and general characteristics of tolerance
- Mechanisms of tolerance: Clonal deletion
- Mechanisms of tolerance: Clonal anergy
- Acquired tolerance
- Experimental approaches to definition of mechanisms of lymphocyte tolerance
- T-lymphocyte tolerance models
- Mucosal tolerance
- Termination of tolerance
- Autoimmunity
- Classification of autoimmune diseases
- Pathophysiology of autoimmune diseases
- Pathogenic factors involved in onset of autoimmune diseases
- Environmental factors
- Animal models of autoimmunity
- Immunomodulation in treatment of autoimmune diseases
- 17. Organ-specific autoimmune diseases
- Autoimmune diseases of the thyroid gland
- Addison's disease (chronic primary hypoadrenalism)
- Autoimmune polyglandular syndromes
- Autoimmune diabetes mellitus
- Acanthosis nigricans
- Autoimmune diseases of the gastrointestinal tract and liver
- Autoimmune diseases of the neuromuscular systems
- 18. Systemic lupus erythematosus.
- Clinical manifestations
- Immunological abnormalities in systemic lupus erythematosus
- Pathogenesis of SLE
- Treatment
- 19. Rheumatoid arthritis
- Clinical and pathological aspects of rheumatoid arthritis
- Autoantibodies in rheumatoid arthritis
- Genetic factors in rheumatoid arthritis
- Immunological factors in pathogenesis of rheumatoid arthritis
- Summary overview of pathogenesis of rheumatoid arthritis
- Therapy
- 20. Overview of hypersensitivity
- Type I hypersensitivity reactions (IgE-mediated hypersensitivity, immediate hypersensitivity)
- Cytotoxic reactions (type II hypersensitivity)
- Immune complex-induced hypersensitivity reactions (type III hypersensitivity)
- Delayed (type IV) hypersensitivity reactions
- 21. IgE-mediated (immediate) hypersensitivity
- Major clinical expressions
- Pathogenesis
- Diagnostic tests for immediate hypersensitivity
- Prevention and therapy
- 22. Immunohematology
- Introduction: Blood groups
- Serological principles of blood transfusion
- Blood transfusion reactions
- Hemolytic anemias
- Autoimmune hematological disorders (AIHDs)
- Autoimmune thrombocytopenias
- Autoimmune neutropenia
- Autoimmune coagulopathies
- 23. Pathogenic role of antigen-antibody complexes
- Host factors that influence development of immune complex disease
- Detection of soluble immune complexes
- Role of immune complexes in human disease
- Therapeutic approaches to immune complex disease
- 24. Immune system modulators
- Immunosuppression
- Immunosuppressive drugs: Pharmacological and immunological aspects
- Adverse effects of prolonged immunosuppression
- Immunopotentiation
- Cancer immunotherapy.
- Bibliography
- 25. Transplantation immunology
- Donor-recipient matching
- Graft rejection
- Graft-versus-host disease
- Road to tolerance: Stem cells and chimerism
- 26. Tumor immunology
- Closing remarks
- 27. Lymphocyte and plasma cell malignancies
- B-Cell dyscrasias
- Leukemias and lymphomas
- 28. Diagnosis of immune deficiency diseases
- Clinical and laboratory diagnosis of immune disorders
- Laboratory assessment of immunity
- Diagnostic testing using molecular genetics
- 29. Primary immunodeficiency diseases
- Immunodeficiencies affecting cellular and humoral immunity
- Combined immunodeficiency with associated or syndromic features
- Predominantly antibody deficiencies
- Gammaglobulin replacement therapy
- Diseases of immune dysregulation
- Congenital phagocytic defects
- Defects in intrinsic and innate immunity
- Phenocopies of primary immune deficiency
- 30. AIDS and other acquired immunodeficiencies
- Secondary immunodeficiencies
- HIV infection and AIDS
- Index.
- Notes:
- Includes bibliographical references and index.
- Description based on online resource; title from digital title page (viewed on April 21, 2020)
- ISBN:
- 1-000-54679-9
- 1-000-53713-7
- 0-429-27899-3
- 9780429278990
- OCLC:
- 1122932319
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.