Encyclopedia of respiratory medicine / editor-in-chief, Sam Janes.

Format:

Book

Contributor:

Janes, Sam M., editor.

Language:

English

Subjects (All):

Respiratory organs--Diseases--Encyclopedias.

Respiratory organs.

Physical Description:

1 online resource (4922 pages)

Edition:

Second edition.

Place of Publication:

Amsterdam, Netherlands ; Kidlington, Oxford ; Cambridge, Massachusetts : Elsevier, [2022]

Summary:

Encyclopedia of Respiratory Medicine, Second Edition, Six Volume Set explores the key processes of lung diseases and their diagnosis and management.The book dissects the molecular and cellular biology, physiology and immunology that underpin normal lung function, along with the aberrations that occur in respiratory diseases, from common disorders.

Contents:

9780081027240v1_WEB

Front matter

ENCYCLOPEDIA OF RESPIRATORY MEDICINE

Copyright

DEDICATION

EDITORIAL BOARD

INTRODUCTION

CONTRIBUTORS TO VOLUME 1

CONTENTS OF VOLUME 1

CONTENTS OF ALL VOLUMES

Type I Cells

Introduction

Ontogeny

Plasticity

Phenotypic Markers

Function in Normal Lung

Function in Respiratory Disease

Conclusion

Acknowledgments

References

Further Reading

Alveolar Epithelial Type II Cells

A Leading Actor in Lung Physiology and Disease

Isolation and Purification of Alveolar Type II Cells

Isolation and Purification Using EpCAM Microbeads

Isolation and Purification Using Negative Selection

Type II Cell Functions in the Healthy Lung

The Production of Pulmonary Surfactant

Ion Transport and Fluid Balance

Regulation of Innate Immunity

Precursor of Alveolar Epithelial Cells

Cellular Crosstalk and Interactions

Subsets of ATII Cells and the Stem Cell Niche

ATII Crosstalk With the Mesenchyme

ATII Crosstalk With Endothelium and Other Cell Types

ATII Cell Function in Respiratory Diseases

ATI Cells in Acute Respiratory Distress Syndrome and Severe COVID-19

Function and Dysfunction in Idiopathic Pulmonary Fibrosis

Possible Role of Alveolar Epithelial Type II Cells in Other Lung Diseases

Endothelial Cells and Endothelium⋆

Structural Considerations

Functions of the Endothelium in the Normal Lung

Regulation of Pulmonary Vascular Resistance

Nitric oxide

Prostacyclin

Thromboxane

Endothelin-1

Angiotensin

Paracellular Permeability and Transcytosis

Inflammatory Responses

Coagulation

Endothelial Progenitor Cells and Induced Pluripotent Stem Cells

Endothelium in Lung Disease

Pulmonary Arterial Hypertension.

Chronic Obstructive Respiratory Disease (COPD)

Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)

Therapeutic Considerations

Organ-On-Chip as New Platforms for Drug Screening

Club Cells

Definition and History of Nomenclature

Characterizing Club Cells in Normal Adult Lung

Secretion and Molecular Markers

Metabolism

Proliferation

Club Cells as Stem Cells

Relationship Between Club and Club-Like Cells

Role of Club Cells in Airway Diseases

Utility of Club Cells or Club Cell Markers as Biomarkers in Airway Diseases

Functional Significance of Club Cells in Disease Pathophysiology

Function of Club Cells in Response to Respiratory Virus Infections

Influenza A Virus

SARS-CoV-2 Virus

Club Cells in Lung Cancer

Acknowledgment

Smooth Muscle Cells

Normal Anatomy and Location of Airway Smooth Muscle

Ultrastructural Features of Airway Smooth Muscle

Ontogeny and Myogenesis of Airway Smooth Muscle

Airway Smooth Muscle Function in the Normal Lung

Airway Smooth Muscle Function in Respiratory Diseases

Increased Airway Smooth Muscle Contraction in Asthma

Mechanisms Underlying Mechanical Plasticity of Airway Smooth Muscle

Enhanced Growth of Airway Smooth Muscle in Lung Disease

Secretory Roles of Airway Smooth Muscle in Asthma

Fibroblasts⋆

Fibroblast Types and Functions in the Normal Lung

Synthesis of Extracellular Matrix Proteins

Secretion of Inflammatory Mediators and Growth Factors

Alveolar Stem/Progenitor Cell Niche

Fibroblasts in Respiratory Diseases

Fibroblasts in Interstitial Lung Diseases

Fibroblasts in Asthma

Fibroblasts in Chronic Obstructive Pulmonary Disease (Chronic Bronchitis and Emphysema).

Fibroblasts in Cancer

Mesothelial Cells

Embryological Origin

Morphology

Functions

Protective Non-Adhesive Barrier

Semi-Permeable Membrane

Inflammation and Immune Regulation

Tissue Repair

Coagulation and Fibrinolysis

Serosal Thickening and Fibrosis

Tumor Growth and Dissemination

Respiratory Diseases

Pleural Adhesions/Plaques and Serosal Thickening

Malignant Mesothelioma

Postnatal Lung Epithelial Stem Cells

Basal Cells

AT2 Cells

Other Progenitor Cell Populations

Stem Cells in Respiratory Disease

Disease Modeling

Stem Cells as Therapy for Respiratory Disease

Vasculogenesis, Angiogenesis and Lung Alveolar Development

Lung Development

Embryonic Stage (E9.5-12 in Mouse, 3-7Weeks in Human)

Pseudoglandular Stage (E12-16.5 in Mouse, 5-17Weeks in Human)

Canalicular Stage (E16.5-17.5Days in Mouse, 16-26Weeks in Human)

Saccular Stage (E17.5 to P5 in Mouse, 26-36Weeks in Human)

Alveolar Stage (P5-30 in Mouse, 36Weeks-8Years Postnatally in Human)

Diseases and Therapeutic Considerations

Congenital Diaphragmatic Hernia (CDH)

Bronchopulmonary Dysplasia (BPD)

Mucins

Mucin Genes and Gene Products

Lung Mucous Cell Differentiation and Mucin Expression

Mucin Gene Regulation

Mucin Glycoproteins

Role of Mucins in Normal Lung Function

Mucins in Disease

Cystic Fibrosis

Asthma

Chronic Obstructive Pulmonary Disease

Idiopathic Pulmonary Fibrosis

Summary

Mucus

Airway mucus components

Sample procurement for analysis of mucosal components

Biophysical/biological properties of mucus.

Mucus and airway diseases

Clinical approaches for treating airway mucus overproduction

Lung Surfactant: Overview

Composition and Production of Lung Surfactant

Functional Activities of Lung Surfactant

Physiological and Biophysical Actions in Normal Respiration

Disruption of Surfactant Activity: Deficiency and Dysfunction

Physiological Correlates of Surfactant Activity and Dysfunction

Lung Surfactant in Respiratory Diseases

Lung Surfactant Therapies

Clinical Exogenous Surfactant Therapy to Prevent or Treat Neonatal RDS (NRDS)

Clinical Exogenous Surfactant Drugs

Relative Activity and Properties of Exogenous Surfactant Drugs

Synthetic Exogenous Surfactant Development

Clinical Exogenous Surfactant Therapy for ALI and ARDS

Selected Issues in Surfactant Therapy in ARDS

Biological Functions of Surfactant Protein A (SP-A) in Health and Disease

Structure

Regulation of Production and Activity

Biological Function

Innate Immunity

Inflammatory or Anti-Inflammatory?

Anti-Microbial Effects

Acquired Immunity

SP-A in Respiratory Disease

Gene Variation and Protein Function

Surfactant Protein B and C (SP-B and SP-C)

Surfactant Protein B

Cellular Localization

Processing

SP-B in Respiratory Diseases

Surfactant Protein C

SP-C in Respiratory Diseases

Therapeutic Perspectives

Relevant Websites

Surfactant protein D (SP-D)

Domain structure

Molecular assembly

Posttranslational modifications

Structure of the lectin domain

Regulation of production and activity.

Sites of synthesis and accumulation

Extrapulmonary sites of synthesis and accumulation

The SP-D gene and collectin locus and regulation of production

Degradation

Biological function

Interactions with carbohydrate and lipid ligands

Mechanism of ligand binding

Interactions with microorganisms and components of microbial cell walls

Interactions with organic particulate antigens

Models of SP-D deficiency

Receptors and interactions with host cells

SP-D in respiratory diseases

Acquired alterations in SP-D levels or activity

Polymorphic variants

Involvement of SP-D in specific diseases: selected examples

Further reading

Integrins

Regulation of Activity

Integrin Ligands in the Lung

Integrins in Respiratory Development and Diseases

Integrins in Lung Development

Integrins and Fibrosis

Integrins and Reactive Airway Disease

Integrins and Acute Lung Injury

Integrins and Viral Pathogens

Integrins and Malignancy

Extracellular Matrix: Basement Membranes

Type IV Collagen

Laminin

Regulation of Production and Assembly

Collagen IV

Nidogen

Receptors

Collagen IV in Respiratory Disease

Laminin in Respiratory Disease

Matricellular Proteins⋆

The Structure of Matricellular Proteins

Thrombospondins 1 and 2

SPARC and Family Members

Tenascins

Osteopontin

CCN Proteins

Fibulins

Biological Functions of Matricellular Proteins

The Role of Matricellular Proteins in Respiratory Diseases

References.

Extracellular Matrix: Matrix Proteoglycans.

Notes:

Four volumes.

Includes bibliographical references.

Description based on print version record.

Description based on publisher supplied metadata and other sources.

ISBN:

0-08-102724-9

OCLC:

1273981182