Active Site-directed Enzyme Inhibitors : Design Concepts / Weiping Zheng.

Format:

Book

Author/Creator:

Zheng, Weiping, author.

Language:

English

Subjects (All):

Enzyme inhibitors.

Physical Description:

1 online resource (210 pages)

Edition:

First edition.

Place of Publication:

London, England : The Royal Society of Chemistry, [2024]

Summary:

This book, authored by Weiping Zheng, delves into the design of active site-directed enzyme inhibitors, highlighting various concepts such as catalytic and substrate-based designs. It provides a comprehensive overview of the strategies used to develop effective inhibitors for different enzymatic reactions crucial to biological processes and therapeutic applications. The text is organized by design concepts, detailing their modes of action and applications across various enzyme classes including transferases, hydrolases, lyases, isomerases, and ligases. Aimed at researchers and students in biochemistry and pharmacology, the book serves as both a reference and a potential textbook for graduate or advanced undergraduate courses. It emphasizes the importance of understanding catalytic mechanisms to innovate inhibitor designs without relying on extensive library screening. Generated by AI.

Contents:

Cover

Preface

Contents

Chapter 1 Catalytic Mechanism- based Design

1.1 Mode of Working

1.2 Applications

1.2.1 Applications with Transferases

1.2.2 Applications with Oxidoreductases

1.2.3 Applications with Hydrolases

1.2.4 Applications with Lyases

1.2.5 Applications with Isomerases

1.2.6 Applications with Ligases

References

Chapter 2 Catalytic Intermediate-based Design

2.1 Mode of Working

2.2 Applications

2.2.1 Applications with Transferases

2.2.2 Applications with Oxidoreductases

2.2.3 Applications with Hydrolases

2.2.4 Applications with Lyases

2.2.5 Applications with Isomerases

2.2.6 Applications with Ligases

Chapter 3 Substrate- based Design

3.1 Mode of Working

3.2 Applications

3.2.1 Applications with Transferases

3.2.2 Applications with Oxidoreductases

3.2.3 Applications with Hydrolases

3.2.4 Applications with Lyases Generated by AI.

Notes:

Includes bibliographical references.

Part of the metadata in this record was created by AI, based on the text of the resource.

Description based on publisher supplied metadata and other sources.

Description based on online resource; title from PDF title page (EBook Central, viewed April 16, 2025).

ISBN:

9781839167669

1839167661

9781837671434

1837671435

OCLC:

1428263515