Medicinal Chemistry : Principles and Practice / Frank D. King.

Format:

Book

Author/Creator:

King, Frank D., author.

Language:

English

Subjects (All):

Pharmaceutical chemistry.

Physical Description:

1 online resource (448 pages)

Place of Publication:

Cambridge, UK : Royal Society of Chemistry, 2023.

Summary:

"This book covers the key topics for drug discovery from the perspective of the practising industrial scientist and manager. Presenting all aspects of the subject from initial lead through to final development, this new edition builds on the foundations laid by the first edition by introducing new topics such as combinatorial chemistry, genomics and cheminformatics, alongside revised and updated original chapters."--Jacket.

Contents:

Drug-receptor interactions

Rob Leurs

An introduction to ion channels

Brian Cox

Intercellular targets

Eric Hunt [and others]

Enzyme inhibitors

David A. Roberts and Walter H.J. Ward

Biological evaluation of novel compounds

Gary W. Price, Graham J. Riley and Derek N. Middlemiss

Pharmacokinetics

Phillip Jeffrey

Drug metabolism

Stephen E. Clarke

Toxicology in the drug discovery process

Susan M. Evans, Elisabeth George and C. Westmoreland

Chemical development

Paul Smith

Physicochemical properties

Han van de Waterbeemd

Quantitative structure. : activity relationships

David J. Livingstone

Computational chemistry and target structure

Colin Edge

Patent medicine

Bill Tyrrell

An introduction to molecular biology

Ralph Rapley and Robert J. Slater

Strategy and tactics in drug discovery

Frank D. King

Combinatorial chemistry : tools for the medicinal chemist

Morag A.M. Easson and David C. Rees

The identification of selective 5-HT2c receptor antagonists : a new approach to the treatment of depression and anxiety

Steven M. Bromidge

The identification of the HIV protease inhibitor. saquinavir

Discovery of vioxx (rofecoxib)

Frank D. King.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

1-83767-086-2