Cholesterol Crystals in Atherosclerosis and Other Related Diseases / edited by George S. Abela, Stefan Mark Nidorf.

Format:

Book

Author/Creator:

Abela, George S.

Contributor:

Nidorf, Stefan Mark.

Series:

Contemporary Cardiology, 2196-8977

Language:

English

Subjects (All):

Cardiology.

Internal medicine.

Internal Medicine.

Local Subjects:

Cardiology.

Internal Medicine.

Physical Description:

1 online resource (499 pages)

Edition:

1st ed. 2023.

Place of Publication:

Cham : Springer International Publishing : Imprint: Humana, 2023.

Summary:

This book is the first authoritative and comprehensive text dedicated to the understanding of how cholesterol triggers vascular inflammation and mechanical injury that leads to heart attacks, strokes as well as other organ and tissue pathology. It includes chapters on the background of cholesterol crystal formation and methods for their detection as well as a description of the physiochemical transformation of metastable ‘liquid’ cholesterol to a solid flat plate crystalloid within the cellular and extracellular environment resulting in volume expansion. Chapters also discusses cholesterol crystals and other crystalloid molecules found in atherosclerotic plaque. In addition, the book examines how cholesterol crystals can induce similar injurious processes in other organs including the retina of the eye to cause blindness, in solid cancers causing further tumor growth and in the brain of patients with Alzheimer’s. And lastly, the book addresses various potential therapeutics that disrupt the physiochemical transformation of cholesterol from a liquid to a solid, inhibit its role in triggering inflammation and tissue injury while ushering a path towards targeted therapies. Cholesterol Crystals in Atherosclerosis and Other Related Diseases will be of interest to cardiologists as well as individuals in various fields of science including crystallography, basic and clinical imaging, cardiac oncology, and drug discovery.

Contents:

Section 1. Detection of Cholesterol Crystals-Why Was it Missing,- Chapter 1. Historical perspective

Chapter 2. New techniques

Section 2: Crystallography-A Molecular Perspective

Chapter 3. Overview

Chapter 4. Cholesterol Crystal Formation

Section 3. Cholesterol Crystals in Atherosclerosis- Atheroma to Atherosclerosis & Beyond

Chapter 5. Lipidology and Atherosclerosis

Chapter 6. Studies of CCs in Cell Culture

Chapter 7. Mechanisms of CC induced Inflammation and atherosclerosis

Chapter 8. Rheumatology/Vascular biology – intersection of gout and atherosclerosis

Chapter 9. Potential of Cholesterol Crystals to cause trauma

Section 4. Cholesterol Crystal Induced Vascular Embolism & End-organ Injury

Chapter 10. Myocardial Injury

Chapter 11. Cerebral, Hollenhorst plaques & Amaurosis fugax, Stroke and TIA

Chapter 12. Muscular

Chapter 13. Cutaneous

Chapter 14. Renal injury

Section 5. Other Cardiac Sites of Cholesterol Crystal injury

Chapter 15. Cardiac Valve Injury by Cholesterol Crystals

Chapter 16. Interaction of Cholesterol Crystals and Bacteria Causing Endocarditis

Chapter 17. Pericardial deposition

Section 6. Interaction of Cholesterol Crystals with Other Crystalloids

Chapter 18. Cholesterol Crystals as a nidus for calcification

Chapter 19. Calcium phosphate crystals as inducers of inflammation

Chapter 20. Monosodium urate crystals as triggers of inflammation

Section 7. A Universal Role of Cholesterol Crystals Beyond Cardiac Disease

Chapter 21. Solid Tumors with crystal induced VEGF

Chapter 22. Alzheimer’s with evidence of cholesterol crystals

Chapter 23. Apical periodontitis

Chapter 24. Biliary disease by cholesterol gall stones

Chapter 25. Ocular retinal injury in diabetic retinopathy

Section 8. Therapeutic Implications - Targeting Cholesterol Crystal Induced Disease

Chapter 26. Lipid lowering with Statins

Chapter 27. Anti-inflammatory Colchicine, canakinumab, Aspirin

Chapter 28. Future Directions and Developments Cyclodextrin.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Abela, George S. Cholesterol Crystals in Atherosclerosis and Other Related Diseases

ISBN:

3-031-41192-7

OCLC:

1410592495