Human iPSC-derived Disease Models for Drug Discovery / edited by Markus H. Kuehn, Wei Zhu.

Format:

Book

Contributor:

Kuehn, Markus H., editor.

Zhu, Wei, editor.

Series:

Handbook of Experimental Pharmacology, 1865-0325 ; 281

Language:

English

Subjects (All):

Neurosciences.

Regenerative medicine.

Stem cells.

Neuroscience.

Regenerative Medicine and Tissue Engineering.

Stem Cell Biology.

Local Subjects:

Neuroscience.

Regenerative Medicine and Tissue Engineering.

Stem Cell Biology.

Physical Description:

1 online resource (331 pages)

Edition:

1st ed. 2023.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2023.

Summary:

Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has beenlost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.

Contents:

Part 1 General considerations

Human iPS for clinical applications and cellular products

3D-printed iPS disease models

Part 2 CNS iPSC and organoids

iPS-derived neurons and brain organoids from patients (brain)

iPS-derived RGCs (eye)

iPS-derived glia (brain)

iPSC to model blood-brain barrier endothelial cells

Part 3 iPSC-derived nociceptive neurons

IPSC-based peripheral nerve modeling

Part 4 Non-neuronal specialized cell types

iPSC-based drug screening of differentiated cardiomyocyte subtypes

iPSC-based cardiac disease modeling: from cell to tissue

iPSC-derived corneal endothelial cell

iPSC-derived trabecular meshwork (eye)

iPSC for in vitro disease modeling of diabetes.

Notes:

Includes bibliographical references.

Other Format:

Print version: Kuehn, Markus H. Human IPSC-Derived Disease Models for Drug Discovery

ISBN:

3-031-42349-6