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Understanding Hepatic REV-ERBα Interacting Partners as It Peaks and Troughs Through the Circadian Day / Delaine M Zundell.
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Zundell, Delaine M., author.
- Language:
- English
- Subjects (All):
- Biochemistry.
- Biology.
- Biophysics.
- Biochemistry and Molecular Biophysics--Penn dissertations.
- Penn dissertations--Biochemistry and Molecular Biophysics.
- Local Subjects:
- Biochemistry.
- Biology.
- Biophysics.
- Biochemistry and Molecular Biophysics--Penn dissertations.
- Penn dissertations--Biochemistry and Molecular Biophysics.
- Physical Description:
- 1 online resource (135 pages)
- Contained In:
- Dissertations Abstracts International 85-03B.
- Place of Publication:
- [Philadelphia, Pennsylvania] : University of Pennsylvania, 2022.
- Ann Arbor : ProQuest Dissertations & Theses, 2023
- Language Note:
- English
- Summary:
- In this thesis the reader will find a body of work that describes new and exciting data about the nuclear receptors REV-ERBaα and REV-ERBβ. REV-ERBs are interesting proteins to understand because they play important roles in the circadian clock and in the regulation of metabolism on a variety of tissues. Understanding how a factor can link both the clock and metabolism could be the key to understanding the negative effects that circadian misalginment has on metabolic and overall health. In chapter 1 we describe the current knowledge of REV-ERBs and their known roles in the circadian clock and metabolism. We also point out the main aims of this project in understanding what proteins and protein complexes does REV-ERB interact with in order to regulate metabolic and clock genes in a tissue specific manner. In chapter 2 we describe our methodology and the preliminary findings of our proteomics data. In chapter 3 we dive into our first target for follow up the discovery that the HDAC1/SIN3a complex interacts with REV-ERB. In chapter 4 we delve into the second novel finding that REV-ERBα gets SUMOylated in a rhythmic manner. Finally we discovered that REV-ERBs play an important role in the regulation of SUMO3 expression in the liver.
- Notes:
- Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
- Advisors: Lazar, Mitchell A.; Committee members: Murphy, Maureen; Wellen, Kathryn E.; Matthews, Megan L.; Burslem, George M.; Hayes, Matthew R.
- Department: Biochemistry and Molecular Biophysics.
- Ph.D. University of Pennsylvania 2023.
- Local Notes:
- School code: 0175
- ISBN:
- 9798380384599
- Access Restriction:
- Restricted for use by site license.
- This item is not available from ProQuest Dissertations & Theses.
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