Cold atmospheric plasma-based cancer therapy / Michael Keidar, Dayun Yan, Li Lin.

Format:

Book

Author/Creator:

Keidar, Michael, author.

Yan, Dayun, author.

Lin, Li (Researcher in plasma physics), author.

Contributor:

Institute of Physics (Great Britain), publisher.

Series:

IOP (Series). Release 23.

IOP series in plasma physics.

IOP ebooks. 2023 collection.

[IOP release $release]

IOP series in plasma physics

IOP ebooks. [2023 collection]

Standardized Title:

Cold plasma cancer therapy.

Language:

English

Subjects (All):

Cancer--Treatment.

Cancer.

Low temperature plasmas--Therapeutic use.

Low temperature plasmas.

Neoplasms--therapy.

Plasma Gases--therapeutic use.

Medical Subjects:

Neoplasms--therapy.

Plasma Gases--therapeutic use.

Physical Description:

1 online resource (various pagings) : illustrations (some color).

Edition:

Second edition.

Place of Publication:

Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2023]

System Details:

Mode of access: World Wide Web.

System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.

Biography/History:

Michael Keidar is an A. James Clark Professor of Engineering. His research concerns plasma physics and engineering with application in plasma medicine, advanced spacecraft propulsion, and plasma-based nanotechnology. He received the 2017 Davidson award in plasma physics. In 2016, he received the AIAA Engineer of the Year award for his work on micropropulsion, which resulted in the successful launch of a nanosatellite with thrusters developed by his laboratory. Dayun Yan is a postdoctoral researcher at George Washington University. His current research focuses on several core problems in plasma sources and plasma medicine. By August 2022, Dayun had published ~60 papers in peer-reviewed journals. He wrote the first edition of Cold Plasma Cancer Therapy. He has been a guest editor of three journals (Applied Sciences, Pharmaceutics, and Biomedicines) and a peer-reviewer for 80+ journals. Li Lin is a postdoctoral researcher at George Washington University. His research interests are low-temperature plasma physics and chemistry, plasma simulation, plasma and biomedical diagnostics, microwave technologies, and machine learning. Li is also an editorial board member of Scientific Reports, an editorial board member of Medical Science, a topic editor of Catalysts, a reviewer board member of Symmetry, and a member of IEEE and APS. Li has published over 40 journal article publications.

Summary:

With the unique chemical and physical properties of cold atmospheric plasmas enabling their recent applications in biomedicine, plasma medicine has established itself as a new scientific field, combining plasma physics, engineering, medicine, and bioengineering. This book provides a comprehensive introduction to the fundamentals of the non-thermal plasmas and plasma devices used in plasma medicine. Several chapters are devoted to the analysis of the mechanisms of plasma interaction with cancer and normal cells, including a description of the mechanism of plasma selectivity. As a revised and significantly expanded second edition, this text includes a detailed description of non-invasive modality, new in vivo work and adaptive plasma written by experts in these areas. This reference text also provides an up-to-date description of the field, the primary challenges and future directions. Part of IOP Series in Plasma Physics.

Contents:

1. Introduction to non-thermal plasma physics

1.1. Plasma

1.2. Plasma quasi-neutrality

1.3. Plasma oscillations

1.4. Particle collisions

1.5. Plasma types

1.6. Cold atmospheric plasmas (CAP)

1.7. CAP in plasma therapy

2. Cold atmospheric plasma generators

2.1. Ionization

2.2. Cold atmospheric plasma

3. Diagnostics and modeling of cold atmospheric plasmas

3.1. General overview of CAP diagnostics

3.2. Numerical simulation and modeling

4. Chemically based cold atmospheric plasma treatment

4.1. Anti-cancer demonstration in vitro

4.2. Two treatment approaches

4.3. Anti-cancer mechanism

5. Cold atmospheric plasma-activated solutions

5.1. Indirect CAP treatment

5.2. Effective components in PAS

5.3. Instability in storage

6. Physics based cold atmospheric plasma therapy

6.1. Limitation of chemically-based treatment

6.2. Revealing physical effect

6.3. Necrotic cell death

6.4. Bubbling and osmotic pressure

6.5. Anti-cancer physical factors in CAP

6.6. Modulating physical effects

6.7. Trans barrier capability

6.8. Physical versus chemical treatment

7. Selective anti-cancer performance

7.1. Selective anti-cancer effect

7.2. Selective anti-cancer mechanism

7.3. H2O2 channels : aquaporins (AQP)

7.4. Antioxidant system

7.5. Transient membrane pores

7.6. Singlet oxygen

7.7. Genomic repairing system

7.8. Novel selectivity concepts

7.9. Summary

8. Animal studies and immune responses

8.1. Cutaneous CAP treatment

8.2. Intracranial models

8.3. Abscopal phenomena

8.4. Sensitization of tumor to drugs

8.5. Transdermal anti-tumor mechanism

8.6. Thermal effect

8.7. Immune responses

9. Clinical perspectives

9.1. Clinical studies

9.2. Outlook

10. Physics and technology of the adaptive plasma therapy

10.1. Plasma self-organization phenomena

10.2. Adaptive plasma devices

10.3. MPC-based adaptive plasma platform

10.4. Electrochemical response of cells to plasma : real-time impedance measurements

10.5. Adaptive plasma treatment based on machine learning technologies

10.6. Intelligent plasma based on self-organization patterns.

Notes:

"Version: 20230901"--Title page verso.

Revised edition of: Cold plasma cancer therapy.

Includes bibliographical references.

Title from PDF title page (viewed on October 3, 2023).

Other Format:

Print version:

ISBN:

9780750355377

9780750355360

OCLC:

1401935858

Access Restriction:

Restricted for use by site license.