Glycolysis : Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions

Format:

Book

Language:

Undetermined

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

Academic Press 2023

Contents:

Front Cover

Glycolysis

Copyright Page

Contents

List of contributors

Preface

I. Introduction

1 Glycolysis: breaking paradigms since Meyerhof's contribution

1.1 Introduction

1.2 Pyruvate or lactate: what is the end product of glycolysis?

1.2.1 The production of lactate

1.2.2 The metabolic fate of lactate

1.3 Glycolytic enzymes work together to maximize their activity

1.4 Control of metabolic damage in glycolysis

1.5 Glycolytic enzymes: more than metabolic players

1.6 Conclusions

References

II. Glycolysis and physiological processes

2 Development and glycolysis dependence

2.1 Metabolism and embryonic development: general considerations

2.2 Temporal control and metabolic switches during embryonic development

2.3 Signaling metabolism interactions during embryonic development

2.4 Metabolism, gene expression regulation, and epigenetic control in embryonic development

2.5 Metabolism, glycolysis, and embryonic development: conclusions and future perspectives

3 Neuro-glia communication and glycolysis

3.1 Introduction

3.2 Brain glucose metabolism: at a glance

3.2.1 Glucose metabolism in neurons and astrocytes

3.2.1.1 Glycolysis, TCA cycle and OXPHOS

3.3 Better together: the important metabolic crosstalk between neurons and glia

3.3.1 Astrocyte-neuron communication: the astrocyte-to-neuron lactate shuttle

3.3.2 Oligodendrocyte-neuron communication

3.3.3 Microglia-neuron communication

3.4 Neuro-glia signaling in neurodegenerative disorders: the case of Alzheimer's disease

3.5 Final remarks

Acknowledgments

4 Glycolysis and skeletal muscle plasticity: lactate as a key signaling molecule

4.1 Introduction

4.2 Skeletal muscle fibers and their reliance on glycolysis

4.3 Feeder pathways for glycolysis

4.3.1 The role of glycogen in supporting glycolysis in skeletal muscle

4.3.2 Different mechanisms of GLUT4 translocation in the skeletal muscle fiber

4.4 Lactate and muscle fiber fatigue

4.5 The role of lactate on mitochondrial biogenesis and functionality

4.6 Conclusions

5 Glucose utilization by the trained heart: the molecular mechanisms behind fuel choice

5.1 Introduction

5.2 Revisiting glucose metabolism in the healthy heart

5.2.1 The role of lactate in cardiac metabolism and beyond

5.3 The contribution of glycolysis to the metabolic remodeling of the trained heart

5.3.1 Mechanical workload regulates glucose utilization

5.3.2 Hormonal regulation of energetic substrates availability

5.3.3 Mitochondria-AMPK interaction in metabolism regulation

5.4 Conclusions

6 Bone glycolysis and the regulation of energy balance

6.1 Introduction

6.2 Bone as an endocrine organ. Who would have thought it?

6.3 Evidence of bone as a regulator of energy homeostasis

Notes:

Machine-generated record

ISBN:

9780323985666

0323985661

OCLC:

1404381645

Access Restriction:

Restricted for use by site license.