Drugs and a Methodological Compendium : From bench to bedside / edited by Vikrant Singh Rajput, Ashish Runthala.

Format:

Book

Contributor:

Rajput, Vikrant Singh, editor.

Runthala, Ashish, editor.

Language:

English

Subjects (All):

Biotechnology.

Drug delivery systems.

Biology.

Pharmaceutical chemistry.

Medicine--Research.

Medicine.

Biology--Research.

Drug Delivery.

Biological Sciences.

Pharmaceutics.

Biomedical Research.

Local Subjects:

Biotechnology.

Drug Delivery.

Biological Sciences.

Pharmaceutics.

Biomedical Research.

Physical Description:

1 online resource (433 pages)

Edition:

1st ed. 2023.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2023.

Summary:

This book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines. .

Contents:

Chapter 1.Computational and informatics methodologies in Drug Discovery, with focus on Natural Products

Chapter 2.Structural biology an essential tool for Drug discovery and Development

Chapter 3.Bioactivity guided fractionation and identification of bioactive molecules: A basic method in drug discovery

Chapter 4.In–vitro methodologies for the safety assessment of drugs

Chapter 5.In-vivo models for evaluation of Drug efficacy: Demand and Challenges

Chapter 6.Preclinical In vivo Drug Development Studies: Limitations, Model Organisms and Techniques

Chapter 7.Peptide Based Therapeutics and Drug Delivery Systems

Chapter 8.Basics of Clinical Drug Development: Clinical Trial and Drug Development

Chapter 9.Trailblazing contemporary frameworks for drug repurposing: A saga on drugs’ expedition to disinter the veiled destiny

Chapter 10.Small molecules as promising tool for targeted cancer therapies: an overview of 21st century

Chapter 11.Nanoparticles for Targeted DrugDelivery Systems with Cancer Therapy in Perspective

Chapter 12.Biomimetic approach for the controlled drug delivery through 3D bioactive scaffolds: A novel strategy for tissue engineering applications

Chapter 13.Perspectives on anti-tuberculosis drug discovery

Chapter 14.Cofactor-Receptor interactions based pharmacophore design for development of novel inhibitors: A case study against Tuberculosis

Chapter 15.Insilico identification of potential antivirals against SARS-CoV2 main protease and RBD of spike protein – A Drug Repurposing Approach

Chapter16.Anti-malarial drug discovery and development: from bench to bedside.

Notes:

Includes bibliographical references.

Other Format:

Print version: Rajput, Vikrant Singh Drugs and a Methodological Compendium

ISBN:

981-19-7952-9