3D printing in medicine / edited by Deepak M. Kalaskar.

Format:

Book

Contributor:

Kalaskar, Deepak M., editor.

Series:

Woodhead Publishing series in biomaterials.

Woodhead Publishing series in biomaterials

Language:

English

Subjects (All):

Three-dimensional printing.

Biomedical materials--Design.

Biomedical materials.

Biomedical materials--Technological innovations.

Printing, Three-Dimensional.

Medical Subjects:

Printing, Three-Dimensional.

Physical Description:

1 online resource (424 pages)

Edition:

Second edition.

Other Title:

Three dimensional printing in medicine

Place of Publication:

Cambridge, Massachusetts ; Kidlington, Oxford : Woodhead Publishing, [2023]

Summary:

3D Printing in Medicine, Second Edition examines the rapidly growing market of 3D-printed biomaterials and their clinical applications. With a particular focus on both commercial and premarket tools, the book looks at their applications within medicine and the future outlook for the field. The chapters are written by field experts actively engaged in educational and research activities at the top universities in the world. The earlier chapters cover the fundamentals of 3D printing, including topics such as materials and hardware. The later chapters go on to cover innovative applications within medicine such as computational analysis of 3D printed constructs, personalized 3D printing - including 3D cell and organ printing and the role of AI - with a subsequent look at the applications of high-resolution printing, 3D printing in diagnostics, drug development, 4D printing, and much more. This updated new edition features completely revised content, with additional new chapters covering organs-on-chips, bioprinting regulations and standards, intellectual properties, and socio-ethical implications of organs-on-demand.

Contents:

Front Cover

3D Printing in Medicine

Copyright Page

Contents

List of contributors

Preface

1 Introduction to three-dimensional printing in medicine

1.1 3D printing is the latest industrial revolution

1.1.1 Brief history of 3D printing

1.1.2 Basic components of 3D printing

1.2 3D bioprinting in medicine

1.2.1 3D bioprinting approaches

1.2.1.1 Biomimicry

1.2.1.2 Independent self-assembly

1.2.1.3 Miniature-tissue blocks

1.2.2 Feasibility of organ printing technology

1.2.3 In vivo behavior of 3D printed organ constructs

1.3 Advantages of 3D printing for medicine

1.3.1 Applications of 3D printing in medicine

1.3.1.1 3D printing for surgical templates and diagnostic tools

1.3.1.2 Organ printing technology

1.3.1.3 3D disease modeling

1.3.1.4 3D printing for commercial pharmaceutical products

1.3.1.5 4D bioprinting

1.3.2 Limitations and challenges of 3D printing

1.4 Future of 3D printing in medicine

1.5 Regulation, intellectual property, ethics and standards for 3D printing in medicine

1.5.1 Commercial 3D bioprinters

1.5.2 International standards and regulatory framework of 3D bioprinting

1.5.2.1 International standards used for 3D bioprinting

1.5.2.2 Regulatory authorities and guidelines

1.5.3 Intellectual property and socio-ethical implications of organ 3D printing

1.5.3.1 Intellectual property in 3D bioprinting

1.5.3.2 Ethics and social concerns of organs on demand

References

2 3D printing families: laser, powder, and nozzle-based techniques

2.1 Introduction

2.2 Classification of 3D printing techniques

2.2.1 Resin-based systems

2.2.2 Powder-based systems

2.2.3 Extrusion-based systems

2.2.4 Droplet-based systems

2.3 Challenges and Food and Drug Administration regulations

2.4 Conclusions and future trends

Acknowledgments.

References

3 Materials for 3D printing in medicine: metals, polymers, ceramics, and hydrogels

3.1 Introduction

3.1.1 Biomaterials

3.1.2 Biocompatibility of biomaterials

3.2 Metals

3.2.1 Conventional metals and their alloys

3.2.1.1 Titanium and its alloys

3.2.1.2 Stainless steel, other metals, and alloys

3.2.2 Shape memory alloys

3.2.3 Biodegradable metals

3.3 Bioceramics and bioactive glasses

3.3.1 Nondegradable bioceramics

3.3.2 Biodegradable and bioactive ceramics and glasses

3.4 Polymers

3.5 Hydrogels

3.5.1 Bioinks for 3D bioprinting

3.5.1.1 Bioink characteristics

Cross-linking mechanisms

Printability

Biocompatibility

Challenges in bioink development

Stability

Mechanical properties

Challenges with printability and cell survival

3.5.2 Natural polymer derived hydrogels

3.5.2.1 Extracellular matrix-derived hyrdogels

3.5.2.2 Nonmammalian sources derived polysaccharides

3.5.2.3 Glycoaminoglycan-based hydrogels

3.5.3 Synthetic polymer derived hydrogels

3.5.4 Photosensitive bioinks

3.6 Composite materials

3.7 Materials for 4D bioprinting

3.8 Summary and outlook

Acknowledgments

4 3D-printed and computational models: a combined approach for patient-specific studies

4.1 Introduction

4.2 Creation of patient-specific models: image reconstruction

4.2.1 Image acquisition

4.2.2 Image segmentation

4.2.3 Geometrical refinement

4.3 Patient-specific models: 3D manufacturing

4.4 Computer simulations of patient-specific cardiovascular models

4.4.1 A very short history of computer modeling and simulations in the cardiovascular field

4.4.2 Validating patient-specific simulations with results from patient-specific experiments.

4.4.3 Enriching the knowledge of cardiovascular biomechanics with combination of computational and 3D printed models

4.4.4 Planning procedures

4.5 Patient-specific models: the current perspective of regulatory bodies and policy makers

4.6 Future perspective of patient-specific models in cardiovascular applications

5 3D printers for surgical practice

5.1 Introduction

5.2 Imaging to printed model: steps involved

5.3 Limitations of CT and MRI images for surgical planning

5.4 3D printed models for anatomical simulation for surgeons

5.4.1 Orthopedic tissues

5.4.2 Cardiac surgery: heart valve surgery

5.4.3 Neurosurgery

5.4.4 Malignant tissues

5.5 Surgical planning of congenital anomalies

5.6 3D printed models for anatomical teaching

5.7 Tissue defect-specific implant design

5.8 3D printing for surgical templates and diagnostic tools

5.9 Advantages of 3D printed models

5.10 Challenges for 3D printed models

5.11 Legal and ethical issues for 3D printing in surgery

5.12 Conclusion

6 Patient-specific 3D bioprinting for in situ tissue engineering and regenerative medicine

6.1 Patient-specific 3D printing

6.1.1 Personalized medicine

6.1.2 Introduction to 3D printing technology: 3D printing in personalized medicine

6.1.3 Patient-specific 3D model creation and application of machine learning and artificial intelligence algorithms

6.2 Current medical applications for 3D printing

6.2.1 3D bioprinting of vascularized organs and tissues in vitro

6.2.2 3D bioprinting of organs for personalized drug screening and disease modeling

6.2.3 In situ 3D bioprinting directly to the defect/wound site

6.2.3.1 Wound repair

6.2.3.2 Bone defect repair

6.3 Challenges and future advancements

6.4 Summary

7 3D-bioprinted in vitro disease models.

7.1 Introduction

7.2 Bioinks

7.3 3D disease modeling

7.3.1 Cancer modeling

7.3.2 Tissues models and new therapies screening

7.3.2.1 3D printed osteoarthritis models

7.4 Concluding remarks and future prospects

8 3D printed pharmaceutical products

8.1 Introduction

8.2 Pharmaceutical 3D printing

8.2.1 Material extrusion

8.2.1.1 Fused filament fabrication

Benefits

Challenges and solutions

8.2.1.2 Pneumatic extrusion

8.2.2 Vat-based 3D printing

8.2.2.1 Benefits

8.2.2.2 Challenges and solutions

8.2.3 Powder bed fusion: selective laser sintering

8.2.3.1 Benefits, challenges and solutions

8.2.4 Inkjet-based 3D printing

8.2.4.1 Benefits, challenges and solutions

8.3 Active pharmaceutical ingredients synthesis and assessment using 3D printing

8.4 Conclusions

9 High-resolution 3D printing for healthcare

9.1 Clinical need and context

9.2 High-resolution 3D printing

9.3 Types of high-resolution 3D printing

9.3.1 Direct-write printing

9.3.2 Electrohydrodynamic printing

9.3.3 3D direct laser writing

9.3.4 Focused ion beam

9.3.5 Digital light process and two-photon photolithography

9.4 Fundamentals of micro/nanofluidics

9.4.1 Micro/nanofluidics

9.4.2 Ink properties: preliminary aspects of rheology

9.4.3 Viscoelasticity

9.4.4 Wetting

9.4.5 Evaporation

9.4.6 Dynamic effects

9.5 Printing materials

9.5.1 Nonbiologic printing materials

9.5.2 Bioink printing

9.6 Exemplar functional devices

9.6.1 Interconnects

9.6.2 Site-specific deposition

9.6.3 Healthcare sensors

9.6.4 Implantable devices

9.6.5 Printed bioscaffolds

9.6.6 Mechanobiology and cell signaling studies

9.6.7 Biomedical microrobots

9.7 Conclusions and future direcions.

10 (Bio)fabrication of microfluidic devices and organs-on-a-chip

10.1 Introduction

10.1.1 Definition and need for organs-on-chips

10.1.2 Rationale for 3D printing for organs-on-chips

10.2 Design and manufacturing principles of an organ-on-a-chip

10.2.1 Microfluidics fundamentals

10.2.2 General flow characteristics

10.2.3 Flow profile and shear stress in a microfluidic channel

10.2.4 Flow resistance of a microfluidic unit

10.2.5 Perfusion strategies

10.2.6 General design requirements

10.2.6.1 Organs-on-chip architecture principles

10.2.6.2 Material of choice: from elastomer to the bioink

10.2.6.3 Interaction between material and cells

10.2.6.4 Cell sourcing

10.3 3D printing technologies for organ-on-a-chip

10.3.1 Extrusion printing

10.3.1.1 Straightforward way for organs-on-chips printing: from a square mold to an entirely 3D printed organ-on-a-chip

10.3.2 Electrohydrodynamic printing

10.3.3 Inkjet printing

10.3.4 Light-assisted (bio)printing

10.3.4.1 Stereolithography and digital light projection

10.3.4.2 Two-photon polymerization

10.3.4.3 Laser-induced forward transfer

10.3.5 Technology convergence and development

10.4 Application overview of 3D printed organ-on-a-chip systems

10.4.1 Cardiovascular system: microfluidic myocardium models

10.4.2 Urinary system

10.4.3 Digestive system

10.4.4 Respiratory system

10.4.5 Integumentary system

10.4.6 Neural system

10.4.7 Other organ systems and pathophysiological models

10.5 Conclusions and outlook

11 Four-dimension printing in healthcare

11.1 Introduction

11.2 Transformation of 3D printing to 4D printing

11.3 Emergence of 4D printing

11.3.1 Pre-requisite for 4D printing

11.4 4D printing strategies.

11.4.1 Stimuli-responsive biomaterials for 4D printing/bioprinting.

Notes:

Description based on print version record.

Includes bibliographical references and index.

Other Format:

Print version: Kalaskar, Deepak M. 3D Printing in Medicine

ISBN:

9780323902205