Anti-obesity drug discovery and development. Volume 4 / edited by Atta-ur-Rehman.

Format:

Book

Author/Creator:

Rahman, Atta-ur, Author.

Contributor:

Rahman, Atta-ur-, 1942- editor.

Series:

Anti-Obesity Drug Discovery and Development ; 4

Language:

English

Subjects (All):

Appetite depressants.

Physical Description:

1 online resource (245 pages)

Edition:

1st ed.

Place of Publication:

Sharjah, United Arab Emirates : Bentham Science Publishers, 2018.

Summary:

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. The incidence of obesity among populations in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from activities focused on raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is a book series focused on this very important area of healthcare research. Each volume presents insightful updates on pharmaceutical research and development for clinical researchers and healthcare professionals involved in obesity treatment programs. The fourth volume of this series is a compilation of 6 reviews on anti-obesity treatment strategies including updates on obesity and cancer prevention through dietary modulation, the role of anti-obesity medications in polycystic ovary syndrome, potential anti-obesity strategies targeting mitochondria, calcium silicate based formulations for anti-obesity therapy, and the identification of obesity medications from natural products and plants.

Contents:

Cover

Title

Biblography

End User License Agreement

Contents

Preface

List of Contributors

Dietary Modulation, Obesity and Cancer Prevention

Jennifer Man Fan Wan1,* and Hiu Yee Kwan2

INTRODUCTION

HOW DIET RELATES TO CANCERS?

Dietary Factors that Promote the Cancer Initiation

Ingestion of Powerful, Direct-Acting Carcinogens or their Precursors

Ingestion of Carcinogens that are Produced via Food Processing

Ingestion of Carcinogens Produced in Stored Food

Formation of Carcinogens in the Body

DIETARY FACTORS THAT PROMOTE THE CANCER DEVELOPMENT

GENERAL MECHANISM OF HOW OBESITY CAN CAUSE AND PROMOTE CANCER

DIETARY COMPONENTS WITH CANCER PREVENTION POTENTIAL

DIETARY COMPONENTS THAT AFFECT BODY WEIGHT

PROSPECTIVE FOR THE ANTI-CANCER STUDY

SUMMARY

ABBREVIATIONS

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

The Role of Anti-Obesity Medications in Polycystic Ovary Syndrome

Ilgın Turkcuoglu1,* and Rauf Melekoglu2

Orlistat, Sibutramine, and Rimonabant

Insulin-sensitizing Drugs (Metformin, Rosiglitazone, Pioglitazone, and D-chiro-inositol)

GLP-1 Agonists (Exenatide, Liraglutide), Phentermine and Topiramate

Other Drugs

Sirtuins and Bile Acids: Potential Anti-obesity Strategies Targeting Mitochondria

João Alves Amorim1,#, João Soeiro Teodoro1,2,#, Carlos Marques Palmeira1,2 and Anabela Pinto Rolo1,2,*

SIRTUIN ACTIVATORS AS A NOVEL ANTI-OBESITY STRATEGY

Sirtuins

Physiological Role of Sirtuins in Metabolism

Physiological Role of Sirtuins and Obesity and Metabolic Syndrome

Sirtuins Activators for Therapy

Sirtuin Activators for Therapy in Obesity

NAD+-boosting Compounds.

BILE ACIDS, OBESITY AND MITOCHONDRIA

Bile Acid Receptors Discovery and Properties

BA Effects and Mitochondria

CONCLUDING REMARKS

Development and Characterization of Calcium Silicate Based Formulations for Anti-Obesity Therapy: Orlistat

Sunil K. Jain*

FLOATING MICROSPHERES

Preparation of OT Absorbed CS

Preparation of Floating Microspheres

Characterization of Floating Microspheres

Micromeritic Properties and Morphology

Percentage Buoyancy and Drug Entrapment

In vivo Drug Release of Floating Microspheres

Gamma Scintigraphy

Pharmacokinetic Studies

FLOATING GRANULES

Preparation of Floating Granules

Characterization of Floating Granules

Drug Content and Floating Ability

In vitro Drug Release of Floating Granules

CONCLUSION

Multi Targeted Strategies Towards Identification of Potential Drug Candidates from Natural Products in the Management of Obesity

Baddireddi Subhadra Lakshmi*, 1,2 and Gopal Thiyagarajan2

CURRENT TREATMENT STRATEGIES FOR OBESITY

MEDICINAL PLANTS AS A SOURCE FOR NOVEL DRUGS

MECHANISM AND MOLECULAR TARGETS OF OBESITY

INHIBITION OF LIPID ABSORPTION

Pancreatic Lipase Inhibitors

SUPPRESSION OF APPETITE

Glucagon Like Peptide 1 Analogues and Dipeptidyl Peptidase 4 Inhibitors

Cholecystokinin Agonists

Neuropeptide Y Antagonist

Leptin

Protein Tyrosine Phosphatase 1B Inhibitors

INHIBITION OF ADIPOGENESIS

Peroxisome Proliferator Activated Receptor γ (PPARγ)

Adiponectin

Partial PPARγ Agonists

ENERGY EXPENDITURE

Thermogenesis

MODULATION OF LIPID METABOLISM

Lipolysis

β-Oxidation

Adenosine Monophosphate (AMP) Kinase Activators.

Sirtuin 1 as a Novel Target of Obesity

MULTIFUNCTIONAL ROLE OF NATURAL ANTIOBESITY COMPOUNDS

CLINICAL TRIALS STUDY

Anti-Obesity Molecules from Plants and their Mode of Action

Megha Valsaraj, Navaneetha Saseendran, Arun Subash Koorapally and Anu Augustine*

GENERAL INTRODUCTION

Obesity

Definition and Assessment of Obesity

Genetic and Environmental Factors Causing Obesity

Endocrine and Metabolic Factors

Psychological Factors

Control of Appetite and Energy Expenditure

Obesity Management

Role of Medicinal Plants in Obesity Treatment

Mechanism of Action of Anti obesity Agents from Plants

Modifying Serum Lipoprotein

Modifying Serum Apolipoproteins

Enzyme Inhibition

Inhibitors of Adipogenesis and Adipogenic Factors

Blocking Intestinal Absorption

Appetite Suppressants

Details of Plants Selected for Study

Holoptelea Integrifolia

Averrhoa bilimbi Linn.

Terminalia chebula Retz.

Acorus calamus Linn.

Picrorhiza kurroa Royle ex Benth

Experimental Model and Findings

Methodology

Animals

Acute Oral Toxicity

Establishment of Experimental Model

Drug Treatment

Effect of Plant Extracts on Serum Lipids

Effect of Plant Extracts on HDL Cholesterol Levels

Effect of Plant Extracts on LDL Cholesterol Levels

Effect of Plant Extracts on Apolipoproteins

Effect of Different Plant Extracts on Enzymes Involved in Cholesterol Pathway

HMG-CoA Reductase

Lecithin-Cholesterol Acyltransferase

Lipoprotein Lipase

Effect of Different Plant Extracts on Intestinal Fat Absorption

Effect of Different Plant Extracts on Inhibition of Adipogenesis and Adipogenic Factors

REFERENCES.

Subject Index

Back Cover.

Notes:

Description based on print version record.

ISBN:

9781681085586

1681085585

OCLC:

1159421134