Transcription factors / J. Locker.

Format:

Book

Author/Creator:

Locker, J., author.

Contributor:

Locker, Joseph, 1947-

Series:

Human molecular genetics series.

Human Molecular Genetics Series

Language:

English

Subjects (All):

Transcription factors.

Genetic transcription--Regulation.

Genetic transcription.

Physical Description:

1 online resource (345 p.)

Place of Publication:

Oxford, [England] : BIOS, 2001.

Language Note:

English

Summary:

Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes and factors that control transcription in eukaryotic cells. It examines the regulatory systems that modulate gene expression in all cells,a s well as the more specialized systems that regulate localized gene expression throughout the mammalian organism.Transcription Factors updates classical knowledge with recent advances to provide

Contents:

Book Cover; Half-Title; Title; Copyright; Contents; Contributors; Abbreviations; Preface; 1 RNA polymerase II transcription machinery; 1. Introduction: promoter function and strategies in gene control; 2. Architecture of the core promoter; 3. Rate-limiting steps in gene expression; 4. Assembly and regulation of the TATA-binding protein and associated factors; 5. Recruitment of the RNA polymerase II holoenzyme; 5.1 Transcription factor TFIIB; 5.2 Transcription factor TFIIF; 5.3 The CTD and the SRB/Mediator complex; 5.4 Transcription factors TFIIE and TFIIH

6. Events subsequent to transcription initiation7. Conclusions and prospects; References; 2 Regulatory transcription factors and cis-regulatory regions; 1. Introduction; 2. Regulatory transcription factors; 2.1 The modular nature of sequence-specific regulators; 2.2 DNA-binding domains; 2.3 Activation domains; 2.4 General transcription factors as activation domain targets; 2.5 Coactivators as activation domain targets; 3. Organization of cis-acting regulatory regions and combinatorial control; 3.1 Combinatorial interactions and developmental complexity

3.2 Combinatorial interactions and signal transduction3.3 Enhanceosomes and the mechanism of transcriptional synergy; 4. Conclusions; References; 3 Chromatin structure and the regulation of transcription; 1. Introduction; 2. Chromosome architecture and transcription; 2.1 The radial loop and helical-folding models of chromosome structure; 2.2 The nuclear matrix, scaffold and skeleton: protein components and their function; 2.3 Chromosome domains, position effect and locus control regions; 3. Nucleosome structure; 3.1 Features; 3.2 Histone H1 and higher-order chromatin structure

4. Chromatin remodeling and histone modification in transcription4.1 Genetic evidence for individual histones and their domains in transcriptional control; 4.2 Structural and functional consequences of acetylation of the core histones; 4.3 Structural and functional consequences of phosphorylation and ubiquitination of the core histones; 4.4 Phosphorylation of linker histones; 5. Transcriptional activators that remodel chromatin; 5.1 The SAGA (PCAF) activator complex; 5.2 Histone acetyltransferases p300 and TAFII250; 5.3 The SWI/SNF complex; 6. Transcriptional repressors that remodel chromatin

6.1 Histone deacetylase and mammalian Sin36.2 Nuclear hormone receptors and histone deacetylase; 6.3 DNA methylation and transcriptional control; 7. Conclusion; References; 4 DNA binding by transcription factors; 1. Principles of protein-DNA recognition; 1.1 Shape recognition; 1.2 Chemical recognition; 1.3 Role of water; 1.4 Role of DNA structure; 1.5 Multiple recognition modules; 1.6 Multiple recognition sites; 2. Architecture of DNA-binding domains; 2.1 Helix-turn-helix containing DNA-binding domains; 2.2 Zinc-containing DNA-binding domains

2.3 Other DNA-binding domains that use a-helices to bind DNA

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-135-32362-3

1-280-07478-7

9786610074785

0-203-45040-X

9780203450406

OCLC:

437057572