Introduction to Toxicological Screening Methods and Good Laboratory Practice / by Saravana Babu Chidambaram, M. Mohamed Essa, M. Walid Qoronfleh.

Format:

Book

Author/Creator:

Chidambaram, Saravana Babu, author.

Essa, M. Mohamed, author.

Qoronfleh, M. Walid, author.

Language:

English

Subjects (All):

Toxicology.

Pharmacology.

Medical sciences.

Drug development.

Pharmacy.

Pharmaceutical chemistry.

Preclinical Research.

Pharmaceutics.

Local Subjects:

Toxicology.

Pharmacology.

Preclinical Research.

Pharmacy.

Pharmaceutics.

Physical Description:

1 online resource (205 pages)

Edition:

1st ed. 2022.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2022.

Summary:

This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.

Contents:

Chapter 1. Introduction to Toxicology

Chapter 2. Laboratory Animal models

Chapter 3. Toxicology Screening Methods

Chapter 4. Toxicokinetics

Chapter 5. Safety Pharmacology

Chapter 6. Good Laboratory Practice.

Notes:

Includes bibliographical references.

Other Format:

Print version: Chidambaram, Saravana Babu Introduction to Toxicological Screening Methods and Good Laboratory Practice

ISBN:

9789811660924

9811660921

9789811660917

9811660913