Functional biomaterials : drug delivery and biomedical applications / edited by Sougata Jana and Subrata Jana.

Format:

Book

Contributor:

Jana, Subrata, editor.

Jana, Sougata, editor.

Language:

English

Subjects (All):

Nanostructured materials.

Drug delivery devices.

Biomedical materials.

Physical Description:

1 online resource (524 pages)

Place of Publication:

Gateway East, Singapore : Springer, [2022]

Summary:

This book explores in depth a wide range of functional biomaterials-based systems for drug, gene delivery, and biomedical aspects. The chapters cover newer technologies such as polymeric micelle, pH-responsive biomaterials, stimuli-responsive hydrogels, silk fibroin, inorganic biomaterials, synthetic biomaterials, 3D printed biomaterials, metallic biomaterials, ceramic and hybrid biomaterials. It also describes the theranostic approaches for cancer therapy, the biomaterials-based nanofibers scaffolds in tissue engineering, as well as the strategies applications of metallic biomaterials for the medical and dental prosthetic field. This newer and updated approach will be attractive for biomedical engineering students working on materials science in the development of novel drug delivery strategies. The book will be an important reference for researchers and professionals working on biomaterial research in the pharmaceutical and medical fields.

Contents:

Intro

Contents

About the Editors

Functional Biomaterials: Drug Delivery and Biomedical Applications Polymeric Micelle in Drug Delivery Applications

1 Introduction

2 Types of PMs

3 Synthesis Materials, Methods, and Characterization of Polymeric Micelles

3.1 Materials for the Synthesis of PMs

3.2 Preparation Methods of PMs

3.2.1 Direct Dissolution

3.2.2 Indirect Dissolution

3.3 Characterization of PMs

4 Targeting Approaches of PMs

4.1 Passive Targeting

4.2 Active Targeting

5 Stimuli-Based Drug Release

5.1 pH-Sensitive PMs

5.2 Thermal-Sensitive PMs

5.3 Redox-Sensitive PMs

5.4 Light-Sensitive PMs

6 Drug Delivery Applications

6.1 Anticancer Drug Delivery

6.2 Gene Delivery

6.3 Immuno Micelles

6.4 Ocular Drug Delivery

6.5 Oral Drug Delivery

7 Conclusion

References

pH-Responsive Biomaterials in Drug Delivery

2 Importance of pH as a Stimulus for Drug Release

3 Polymeric Carrier as Biomaterial.

3.1 Properties of pH-Responsive Polymers

4 Classification of Polymeric Carrier as Biomaterial

4.1 Natural Polymers

4.1.1 Alginates

4.1.2 Chitosan

4.1.3 Pullulan

4.1.4 Carboxymethylcellulose

4.1.5 Hyaluronic Acid

4.1.6 Starch and Dextran

4.1.7 Polyurethane

4.2 Synthetic pH-Responsive Polymers

4.2.1 Polyacids/Polyanions based pH-Responsive Polymers

4.2.2 Polybases/Polycations based pH-Responsive Polymers

4.2.3 Block Copolymers

4.2.4 Polymer Brushes and Comb

4.2.5 Hydrogels

5 pH-Sensitive Bonds

5.1 Imine Bonds

5.2 Hydrazone Bonds

5.3 Oxime Bonds

5.4 Amide Bonds

5.5 Acetals

6 Mechanism of pH-Responsive Behavior of Biomaterials

6.1 Protonation as a Response to Change in pH

6.2 Acid Labile Bond Cleavage

6.3 Acid Labile Bond Cleavage for the Detachment of PEG.

7 Application of pH-Responsive Biomaterials in Drug Delivery

7.1 Oral Drug Delivery for Organ Targeting

7.1.1 Oral Drug Delivery for Local Action in the Stomach

7.1.2 Oral Drug Delivery for Local Action in Colon

7.1.3 Oral Drug Delivery for Protein and Peptide

7.1.4 Oral Drug Delivery for Vaccine and Immunotherapeutics

7.2 Tissue-Level Drug Delivery/Tumor Targeting

7.3 Intracellular Delivery

8 Summary

Stimuli-Responsive Hydrogels in Drug Delivery

2 Release Mechanisms for Drugs

2.1 Mathematical Models

3 Polymers Used in the Fabrication of Stimuli-Responsive Hydrogels for Controlled Drug Delivery

3.1 Natural Polymers

3.2 Synthetic Polymers

3.3 Hybrid Polymers

4 Stimuli-Responsive Hydrogels in Drug Delivery

4.1 Thermo-responsive

4.2 pH-Responsive

4.3 Photoresponsive

4.4 Analyte-Responsive Hydrogels

4.5 Ultrasound

4.6 Others

5 Advances in Stimuli-Responsive Hydrogels for Drug Release

5.1 Transdermal

5.2 Vaginal

5.3 Ocular

5.4 Oral Delivery

5.5 Nasal

6 Conclusion

Polysaccharide Based Biomaterials for Dermal Applications

2 Categorization of Natural Polysaccharides

2.1 According to the Ionic Nature

2.2 According to the Origin

2.3 According to the Shape

3 Polysaccharides Used in TDDS

3.1 Starch

3.2 Cellulose

3.3 Chitin and Chitosan

3.4 Hyaluronic Acid

3.5 Alginate/Sodium Alginate

4 Conclusion

Biomaterials in Gene Delivery

2 Classification and Biological Performance of Biomaterials

3 Properties of Biomaterials

3.1 Physical Properties

3.2 Chemical Properties

3.3 Mechanical Properties

3.4 Host Response to Biomaterials

4 Use of Biomaterials in Medical Fields

5 Gene Delivery and Biological Barrier.

6 Engineering Challenges to Gene Transfer

7 Vectors Associated with Biomaterials Carriers

8 Gene Delivery Based on Non-viral Vectors

9 Biomaterials in Gene Delivery

9.1 Lipid-Based Gene Vectors

9.2 PLL-Based Gene Vectors

9.3 Polyethylenimine-Based Gene Vectors

9.4 Polyamidoamine Dendrimers-Based Gene Vectors

9.5 Chitosan-Based Gene Vector

10 Practical Application of Gene Delivery Systems

11 Perspective of Biomaterials for Gene Delivery

12 Conclusion

Polymeric Nanoparticles for Theranostic Treatment of Cancer

2 Polymeric Nanoparticles in Cancer Treatment

2.1 Passive-Targeting Strategies

2.2 Active-Targeting Strategies

3 Design of Polymer-Based Nanotheranostics for Cancer

3.1 Fluorescence Imaging

3.2 X-Ray Computed Tomography

3.3 Magnetic Resonance Imaging

3.4 Positron Emission Tomography

3.5 Single-Photon Emission Computed Tomography

3.6 Ultrasound Imaging

4 Multimodal Theranostic Nanoparticles

5 Polymeric Nanotheranostic Currently in Clinical Trials

6 Conclusions and Remarking for Future Perspectives

Smart Theranostic Biomaterials for Advanced Healthcare Application

2 Biomaterials

3 Natural Biomaterials

3.1 Polysaccharide Biomaterials

3.2 Protein Biomaterials

3.3 Decellularized Biomaterials

4 Synthetic Biomaterial

4.1 Metals

4.2 Ceramics

4.3 Glass

4.4 Polymers

5 Theranostic Biomaterials

6 Applications of Theranostic Biomaterials

7 Imaging

8 Therapy

9 Future Perspectives

10 Conclusion

Silk Fibroin-Based Biomaterials in Biomedical Applications

2 Life Cycle of Silkworm

3 Extraction Process of Silk Fibroin from Bombyx Mori Cocoons

3.1 Dissolution of Silk Fibroin

4 Cross-Linking Strategies for Silk Fibroin.

5 Morphological Diversity of Silk Fibroin into Various Forms

5.1 Hydrogel

5.2 Sponges

5.3 Electrospun Silk Fibers

5.4 Microspheres

5.5 Films

5.6 Tubes

6 Biomedical Applications of Silk Fibroin Based Materials

6.1 Bone

6.2 Articular Cartilage

6.3 Cornea

6.4 Wound Healing

6.5 Vascular Graft

6.6 Drug Delivery

6.7 Gene Delivery

7 Future Perspectives

Biomaterial-Based Nanofibers Scaffolds in Tissue Engineering Application

2 Bone Fracture Statistics

3 Bone and Biomaterials

4 Nanofibrous Scaffolds

5 Analogous Functions of Scaffolds and Extracellular Matrix

6 Materials for Scaffolds

7 Fabrication Techniques

8 Scaffold Applications

9 Latest Developments and Challenges

10 Conclusion and Future Perspectives

Biomedical Applications of Inorganic Biomaterials

2 Nonmetallic Biomaterials

2.1 Ceramic Biomaterials

2.1.1 Biodegradable or Resorbable Ceramics

Calcium Phosphate

Coralline

Zinc-Calcium-Phosphorous Oxide (ZCAP) Ceramics

2.1.2 Bioactive Ceramics

Bioglass

Ceravitals

Hydroxyapatite

2.1.3 Bioinert Ceramics

Alumina Ceramics

Zirconia Ceramics

Carbon Ceramics

2.2 Biocomposites

2.2.1 Classification of Composites

Fibrous Composites

Particulate Composite

2.3 Polymeric Biomaterials

2.3.1 Rubber

2.3.2 Polyphosphate

2.3.3 Biosilica

3 Drawbacks of the Inorganic Biomaterials

Synthesis Biomaterials in Biomedical Applications

1.1 Design of Biomaterial

1.1.1 Polymer Materials

1.1.2 Metal Biomaterials

1.1.3 Synthesis Composite Materials

1.1.4 Ceramics Materials

2 Synthetic Biomaterials

2.1 Synthesis Polymer Biomaterials for Biomedical Applications

2.2 Synthetic Biodegradable Polymers.

2.3 Synthetic Biodegradable Polymer in Tissue Engineering Applications

2.3.1 Nerve Repair

2.3.2 Skin Regeneration

2.3.3 Bone Regeneration

2.4 Biodegradable Synthetic Polymer in Drug Delivery Application

3 Synthetic Conducting Polymer

3.1 Types of Conduction Polymers

3.2 Biomedical Application of Conducting Polymer

3.2.1 Tissue Engineering Application of Synthesis Conducting Polymer

Neural Applications

Conducting Polymer in Cardiovascular Tissue Engineering

3.2.2 Drug Delivery Application of Synthetic Conducting Polymer

4 Synthetic Polymer Hydrogel

4.1 Biomedical Application of Synthetic Polymer Hydrogel

5 Stimuli-Responsive Synthetic Polymer

5.1 Temperature and pH-Responsive Synthetic Polymers

5.2 Stimuli-Responsive Synthetic Biopolymer

5.3 Responsive Synthetic for Biological Polymer Micelles

5.4 Stimuli-Responsive Synthetic Polymers Application

5.4.1 Actuators and Artificial Muscles Application

5.4.2 Sensors

5.4.3 Controlled Drug Delivery

5.4.4 Gene Delivery

6 Polyelectrolytes (PEs) for Biomedical Applications

6.1 Types of Polyelectrolyte Complex (PEC)

6.2 Preparation of Polyelectrolytes

6.3 Applications of PECs in Wound Healing

6.3.1 Wound Dressing

6.3.2 PEC-in Wound Dressings Applications

6.4 Drug Delivery Application of PECs

6.5 Tissue Engineering Application of PECs

7 Synthetic Fluorescent Gold Nanoclusters for Detecting Applications in Cancer Treatment

7.1 Strategies for the Synthesis of Gold Nanoparticles (AuNPs)

7.1.1 Dendrimer

7.1.2 Proteins

7.2 Biomedical Applications of AuNCs

7.2.1 Imaging Biography and Targeted Therapy Application of AuNCs

Biosensors

8 Synthetic Biomaterials with Antimicrobial Properties

8.1 Silvernanoparticles as Antimicrobial Agent in Biomedical Application

8.2 Silver-Polymeric Nanocomposites.

8.3 Silver-Inorganic Nanocomposites.

Notes:

Includes bibliographical references and index.

Description based on print version record.

Other Format:

Print version: Jana, Sougata Functional Biomaterials

ISBN:

981-16-7151-6

981-16-7152-4