Comparación de la composición química de extractos bioactivos de Ageratina havanensis (Kunth) R. M. King & H. Rob..

Format:

Book

Author/Creator:

García Pérez, Trina Haydee.

Language:

Spanish

Subjects (All):

Flavonoids.

Antioxidants.

Physical Description:

1 online resource (161 pages)

Place of Publication:

La Habana : Editorial Universitaria, 2017.

Summary:

This doctoral thesis by Trina Haydee García Pérez focuses on the comparative chemical analysis of bioactive extracts from Ageratina havanensis, a plant species native to Cuba, during two phenological stages: flowering and vegetative. The study investigates the qualitative and quantitative composition of secondary metabolites, particularly flavonoids and sesquiterpene lactones, using advanced techniques like UPLC and FIA/IT. The research also evaluates the antioxidant potential of the extracts through DPPH and FRAP assays and examines their ability to modulate P-glycoprotein function, which has implications for cancer therapy. The findings reveal stage-dependent variations in metabolite concentrations, with vegetative-stage extracts exhibiting stronger iron-reducing capacity and flowering-stage extracts demonstrating higher free radical scavenging activity. This work is intended for researchers and professionals in natural product chemistry, pharmacology, and related fields, aiming to contribute to sustainable biodiversity use and potential therapeutic applications. Generated by AI.

Contents:

COMPARACIÓN DE LA COMPOSICIÓN QUÍMICA DE (...)

PÁGINA LEGAL

ÍNDICE

AGRADECIMIENTOS

RESUMEN

ABSTRACT

ABREVIATURAS

INTRODUCCIÓN

OBJETIVO GENERAL

OBJETIVOS ESPECÍFICOS

NOVEDAD CIENTÍFICA

I. REVISIÓN BIBLIOGRÁFICA

I.1 DESCRIPCIÓN BOTÁNICA DE LA FAMILIA (...)

I.2. DESCRIPCIÓN Y DISTRIBUCIÓN DE LA PLANTA (...)

I.3. USO POPULAR DE ESPECIES DEL GÉNERO

I.4. ACTIVIDAD BIOLÓGICA REPORTADA PARA (...)

I.5. METABOLITOS SECUNDARIOS AISLADOS DEL (...)

I.6. ANTECEDENTES DEL ESTUDIO FITOQUÍMICO (...)

I.7. FLAVONOIDES

I.7.1. ESTRUCTURA

I.7.2. ACTIVIDAD BIOLÓGICA

I.7.3. ELUCIDACIÓN ESTRUCTURAL DE FLAVONOIDES

I.7.4. ESPECTROMETRÍA DE MASAS

I.8. LACTONAS SESQUITERPÉNICAS

I.9. ESPECTROMETRÍA DE MASAS EN TÁNDEM

I.10. CUANTIFICACIÓN DE METABOLITOS SECUNDARIOS

I.11. ANÁLISIS DE COMPONENTES PRINCIPALES (...)

I.12. ACTIVIDAD ANTIOXIDANTE

I.13. MODULACIÓN DE LA FUNCIÓN DE LA (...)

II. PARTE EXPERIMENTAL Generated by AI.

Notes:

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

ISBN:

959-16-3950-3

OCLC:

1048902263