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Modelación matemática de la polimerización de la hemoglobina S mediante ecuaciones diferenciales.

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Format:
Book
Author/Creator:
Sánchez Domínguez, Sandy.
Language:
Spanish
Subjects (All):
Sickle cell anemia.
Hemoglobin.
Physical Description:
1 online resource (118 pages)
Place of Publication:
La Habana : Editorial Universitaria, 2015.
Summary:
This work presents a mathematical modeling of the polymerization process of hemoglobin S (HbS), which is the primary pathophysiological event in Sickle Cell Anemia (SCA). The study employs differential equations to generalize existing models, considering both oxygenated and deoxygenated states of HbS. The model includes monomers, polymers, and domains of HbS and introduces the Quasi-normal Combined Form to enhance the analytical theory of differential equations. The research applies Floquet theory and Magnus expansion to reduce computational effort and provides morphological insights into polymer formation. This work aims to offer clinical estimates of the basal state of individuals, potentially aiding in the evaluation of treatments at the molecular level. The intended audience includes researchers and professionals in mathematical modeling and biomedical sciences. Generated by AI.
Contents:
MODELACIÓN MATEMÁTICA DE LA POLIMERIZACIÓN (...)
PÁGINA LEGAL
SÍNTESIS
ÍNDICE GENERAL
INTRODUCCIÓN
1. ANEMIA DREPANOCÍTICA Y SU MODELACIÓN (...)
2. TRATAMIENTO DEL MODELO AUTÓNOMO
2.1. DEFINICIONES FUNDAMENTALES
2.2. POLIMERIZACI´ON EN AUSENCIA DE CRISTALIZACI´ON
2.3. FASE AVANZADA DE LA CRISTALIZACI´ON
2.4. FORMA CUASI-NORMAL
2.5. FORMA CUASI-NORMAL COMBINADA
2.6. OTROS CASOS PARTICULARES DE INTER´ES
2.6.1. TRATAMIENTO CUALITATIVO EN UN ENTORNO (...)
2.6.2. TRATAMIENTO CUALITATIVO EN UN ENTORNO (...)
2.7. CONCLUSIONES PARCIALES DEL CAP´ITULO
3. TRATAMIENTO DEL MODELO NO AUTÓNOMO
3.1. POLIMERIZACI´ON EN AUSENCIA DE CRISTALIZACI´ON
3.2. FASE AVANZADA DE LA CRISTALIZACI´ON
3.3. CASO CON UN PAR DE VALORES PROPIOS (...)
3.4. FORMA CUASI-NORMAL
3.5. CASO EN QUE APARECE UN VALOR PROPIO (...)
3.6. FORMA CUASI-NORMAL COMBINADA
3.7. TRATAMIENTO CON COEFICIENTES PERI´ODICOS
3.8. CONCLUSIONES PARCIALES DEL CAP´ITULO
4. LA EXPANSÍON DE MAGNUS Y LA ANEMIA DREPANOCÍTICA
4.1. APROXIMACIONES CON INTEGRALES UNIVARIABLES
4.2. APLICABILIDAD EN LA TEORÍA DE LA PERTURBACIÓN
4.3. EJEMPLOS ILUSTRATIVOS
4.4. EJEMPLO DE LA ANEMIA DREPANOC´ITICA Generated by AI.
Notes:
Description based on publisher supplied metadata and other sources.
Part of the metadata in this record was created by AI, based on the text of the resource.
ISBN:
9789591640338
9591640331
OCLC:
1083464634

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