A handbook on estrogen receptors in the brain / Vijay Paramanik.

Format:

Book

Author/Creator:

Paramanik, Vijay, author.

Series:

Neuroscience research progress series.

Neuroscience Research Process

Language:

English

Subjects (All):

Estrogen--Physiological effect.

Estrogen.

Estrogen--Inhibitors--Physiological effect.

Physical Description:

1 online resource (96 pages) : illustrations.

Place of Publication:

New York : Nova Biomedical, 2016.

Summary:

The present book covers estrogen, its receptors and estrogen mediated gene regulation in the brain. Further, it explains the mechanism of estrogen action and dysfunction leading to diseases. Briefly, estrogen mediates its multiple functions in the brain through two well-characterized receptors: ER? and ER'. Upon binding with estrogen, ER recruits coregulators, which are responsible for tissue specific regulation. When coregulators activate the transcription of a particular gene, they become coactivators; when they repress the activity of particular gene, they are called corepressors. These coregulators make a bridge between the basal transcription machinery and the receptors by protein-protein interaction. Estrogen disrupters are also explained in this book. Furthermore, the role of estrogen and its receptors are explained in the context of aging. Taken together, this book shall be self-explanatory concerning estrogen action in the brain in various aspects. Therefore, it is intended for researchers interested in the aforementioned aspects.

Contents:

Introduction to estrogen

Synthesis of estrogen

Estrogen receptors

Different types of estrogen receptors

Mechanism of estrogen action

Estrogen disrupters

Estrogen, ERs, coregulators and diseases

Estrogen, ERs, coregulators and aging

Conclusion.

Notes:

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-5361-0100-1