Cardiac mechano-electric coupling and arrhythmias / [edited by] Peter Kohl, Frederick Sachs, and Michael R. Franz.

Format:

Book

Contributor:

Kohl, Peter, MD

Sachs, Frederick.

Franz, M. R. (Michael R.), 1949-

Kohl, Peter, MD.

Language:

English

Subjects (All):

Heart--Contraction.

Heart.

Arrhythmia.

Heart conduction system.

Biological control systems.

Physical Description:

1 online resource (508 p.)

Edition:

2nd ed.

Place of Publication:

Oxford ; New York : Oxford University Press, 2011.

Language Note:

English

Summary:

Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction. Information is grouped into logical sections, from molecular mechanisms, to cell, tissue and whole organ responses, rightthrough to patient-based observations and insight emerging from clinical trials. The information provided carefully highlight

Contents:

Cover; Contents; Contributors; List of abbreviations; BASIC SCIENCE, SECTION I: Sub-cellular mechanisms of cardiac mechano-electric coupling; 1. Evolutionary origins of stretch-activated ion channels; 2. Stretch-activated channels in the heart; 3. The mechano-gated K[sub(2P)] channel TREK-1 in the cardiovascular system; 4. Cell volume-sensitive ion channels and transporters in cardiac myocytes; 5. Non-sarcolemmal stretchactivated channels; 6. Pacemaker, potassium, calcium, sodium: stretch modulation of the voltage-gated channels

7. Role of caveolae in stretch-sensing: implications for mechano-electric coupling8. The membrane/cytoskeleton interface and stretch-activated channels; 9. Cardiomyocyte stretch-sensing; 10. The response of cardiac muscle to stretch: calcium and force; 11. Stretch effects on second messengers; 12. Functional implications of myocyte architecture; BASIC SCIENCE, SECTION II: Cellular manifestations of cardiac mechano-electric coupling; 13. Mechanical modulation of pacemaker electrophysiology; 14. Mechano-electric coupling in working cardiomyocytes: diastolic and systolic effects

15. Mechano-sensitivity of pulmonary vein cells: implications for atrial arrhythmogenesis16. Heterogeneity of sarcomere length and function as a cause of arrhythmogenic calcium waves; 17. Cellular mechanisms of arrhythmogenic cardiac alternans; 18. Remodelling of gap junctions in ventricular myocardium, effects of cell-to-cell adhesion, mediators of hypertrophy; 19. The origin of fibroblasts, extracellular matrix and potential contributions to cardiac mechano-electric coupling; 20. Advantages and pitfalls of cell cultures as model systems to study cardiac mechano-electric coupling

BASIC SCIENCE, SECTION III: Multi-cellular manifestations of mechano-electric coupling21. Activation sequence of cardiac muscle in simplified experimental models: relevance for cardiac mechano-electric coupling; 22. Mechanical triggers and facilitators of ventricular tachy-arrhythmias; 23. Acute stretch effects on atrial electrophysiology; 24. Stretch effects on potassium accumulation and alternans in pathological myocardium; 25. The effects of wall stretch on ventricular conduction and refractoriness in the whole heart; 26. Mechanical triggers of long-term ventricular electrical remodelling

27. Mechanisms of mechanical pre- and postconditioningTRANSLATIONAL SCIENCE, SECTION IV: Integrated model systems to study specific cases of cardiac MEC and arrhythmias; 28. Mechano-electric coupling in chronic atrial fibrillation; 29. Mechanically induced pulmonary vein ectopy: insight from animal models; 30. Regional variation in mechano-electric coupling: the right ventricle; 31. Mechanical induction of arrhythmia in the ex situ heart: insight into Commotio cordis; 32. Arrhythmias in murine models of the mechanically impaired heart; 33. Studying cardiac mechano-sensitivity in man

34. Mathematical models of cardiac structure and function: mechanistic insights from models of heart failure

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Related Work:

Kohl, Peter, MD. Cardiac mechano-electric feedback and arrhythmias.

ISBN:

0-19-177069-8

1-283-58193-0

9786613894380

0-19-162147-1

OCLC:

801406035