Rapamycin : effectiveness, safety and drug interactions / Martin J. Blanco, Agustina M. Torres.

Format:

Book

Author/Creator:

Blanco, Martin J.

Contributor:

Torres, Agustina M.

Series:

Pharmacology - Research, Safety Testing and Regulation

Language:

English

Subjects (All):

Rapamycin.

Immunosuppressive agents.

Physical Description:

1 online resource (146 p.)

Place of Publication:

New York : Nova Science Publishers, Inc., 2012.

Language Note:

English

Summary:

Rapamycin is a macrocyclic natural product involved in various biological and pharmacological processes including antifungal, immunosuppressive, antitumor, neuroprotective and antiaging activities. In this book, the authors present current research in the study of the effectiveness, safety and drug interactions of rapamycin. Topics discussed include mTOR inhibitors in chronic liver diseases and cancer; rapamycin analogs temsirolimus and everolimus in the treatment of renal cancer; rapamycin control of multiple signalling pathways involved in cancer cell survival and drug resistance to rapamycin through elevated phospholipase D activity. (Imprint: Nova Biomedical)

Contents:

""RAPAMYCIN""; ""EFFECTIVENESS, SAFETYAND DRUG INTERACTIONS""; ""PHARMACOLOGY - RESEARCH, SAFETYTESTING AND REGULATION""; ""ORGAN TRANSPLANTATIONRESEARCH HORIZONS""; ""Library of Congress Cataloging-in-Publication Data""; ""Contents""; ""Preface""; ""mTOR Inhibitors in Chronic LiverDiseases and Cancer""; ""Abstract""; ""1. Introduction""; ""2. mTOR Signaling in the Liver""; ""mTOR Inhibitors""; ""3. mTOR Inhibition in Chronic LiverDiseases""; ""Steatosis and Insulin Resistance""; ""Steatohepatitis and Fibrogenesis""; ""Cirrhosis""

""4. Relevance of mTOR Inhibition inHepatocellular Carcinoma""""Conclusions""; ""References""; ""Starvation Profileof mTOR Inhibitors""; ""Abstract""; ""I. Introduction""; ""2. The Safety Profile of mTOR Inhibitors""; ""2.1. Hyperglycemia""; ""2.2. Dyslipidemia""; ""2.3. Asthenia""; ""2.4. Mucositis, Stomatitis and Mouth Sores""; ""2.5. Pulmonary Toxicity""; ""2.6. Skin Toxicity""; ""2.7. Infection and Malignancy""; ""2.8. Bone Marrow Suppression""; ""2.9. Renal Function Abnormalities""; ""3. mTOR Function in Normal CellPhysiology""; ""3.1. Regulation of Growth Factor Signaling""

""3.2. Regulation of Cell Growth and Metabolism""""4. mTOR Integrates Energy-SensingPathways""; ""4.1. AKT: The Link betweenMetabolism and Extracellular Signals""; ""4.2. mTOR Controls the Interfacebetween Nutrient Sensing and Metabolism""; ""4.3. AMPK: A Low-Energy Checkpoint""; ""4.4. AMP-Activated Kinase Controls the Metabolic Checkpoint""; ""5. mTOR Toxicity on Signaling Pathways""; ""6. Leptin""; ""7. Body Weight and Feeding""; ""8. Cross-Talk among mTOR/PKA/AMP""; ""Conclusion""; ""References""

""Identification of CandidateBiomarkers Predicting Responseto Rapalogs Therapyin Human Cancer""""Abstract""; ""Introduction""; ""Pathway-based Identificationof Predictive Biomarker""; ""Omics-based Identificationof Predictive Biomarker""; ""Conclusion""; ""References""; ""Influence of Everolimus DrugRegime on Blood Cell Subsetsin Kidney Transplant Patients""; ""Abstract""; ""Introduction""; ""Materials and Methods""; ""Blood Leukocyte and LymphocyteSubset Measurement""; ""Results""; ""Discussion""; ""References""

""The Emerging Mechanismof Limited Therapeutic Efficacyof Rapamycin for Cancers""""Abstract""; ""Introduction""; ""a) Overview of Rapamycin""; ""b) Overview of the mTOR Signaling Pathway""; ""c) Overview of Limited Clinical Application of Rapamycinand Its Analogs for Cancer""; ""Rapamycin Can Only Partially InhibitmTORC1 Activity""; ""Rapamycin Cannot Inhibit mTORC2Activity upon Acute Treatment""; ""PI3K/Akt Feedback Loop NegativelyRegulates mTORC1 Activity""; ""Conclusions""; ""References""; ""Rapamycin Controls MultipleSignalling Pathways Involvedin Cancer Cell Survival*""; ""Abstract""

""Introduction""

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-61942-644-7