Cellular signaling and innate immune responses to RNA virus infections [electronic resource] / edited by Allan R. Brasier, Adolfo García-Sastre, Stanley M. Lemon.

Format:

Book

Contributor:

Brasier, Allan R.

García-Sastre, Adolfo.

Lemon, Stanley M.

Language:

English

Subjects (All):

RNA viruses.

Natural immunity.

Cellular signal transduction.

Virus diseases--Immunological aspects.

Virus diseases.

Physical Description:

1 online resource (456 p.)

Place of Publication:

Washington, D.C. : ASM Press, c2009.

Language Note:

English

Summary:

Divided into two major sections, this volume synthesizes recent findings in this fast-moving field while also reviewing accepted knowledge. The first part focuses on the antiviral signaling pathways in the host, including specific pattern recognition receptors (PRRs) and how these cellular alarms signal the innate immune response. The second section examines the ways in which specific major RNA virus families interact with, activate, and elude these signaling pathways and responses.

Contents:

Role of toll-like receptors in the innate immune response to RNA viruses / Sinéad E. Keating and Andrew G. Bowie

Cytoplasmic pattern receptors and signaling in viral infections / Osamu Takeuchi and Shizuo Akira

Mitochondrial antiviral signaling / Vijay G. Bhoj and Zhijian J. Chen

Interferon regulatory factors and the atypical IKK-related kinases TBK1 and IKK? : essential players in the innate immune response to RNA virus infection / Meztli Arguello, Suzanne Paz, and John Hiscott

Jak-stat pathway in response to virus infection / Joan E. Durbin

Interferons and antiviral action / Christine L. White and Ganes C. Sen

The nuclear factor-kB transcription factor pathway / Amer A. Beg and Xingyu Wang

The nuclear factor-kB signaling network : insights from systems approaches / Allan R. Brasier

Type 1 interferon signaling in shaping cellular innate and adaptive immunity to viral infection / Christine A. Biron

Biological impact of type I interferon induction pathways beyond their antivirus activity / Bahram Razani ... [et al.]

Human genetic factors involved in viral pathogenesis / Lennart Svensson and Elin Kindberg

RNA virus families : distinguishing characteristics, differences, and similarities / Peter W. Mason and Frank Scholle

Rhabdoviruses and mechanisms of type I interferon antagonism / Krzysztof Brzózka and Karl-Klaus Conzelmann

Filoviruses / Christopher F. Basler

Inhibition of antiviral signaling pathways by paramyxovirus proteins / Antonella Casola ... [et al.]

Suppression of innate immunity by orthomyxoviruses / Randy A. Albrecht and Adolfo García-Sastre

Bunyaviruses and innate immunity / Friedemann Weber and Richard M. Elliott

Arenaviruses / Juan C. de la Torre

Regulation of innate immunity by the flaviviridae / Brenda L. Fredericksen and Michael Gale Jr.

Evasion of innate host antiviral defenses by picornaviruses / Stanley M. Lemon

Togaviruses / William B. Klimstra and Kate D. Ryman

Coronaviruses and arteriviruses / Krishna Narayanan and Shinji Makino

Caliciviridae and astroviridae / Susana Guix and Mary K. Estes

Innate immune responses elicited by reovirus and rotavirus / Barbara Sherry, John T. Patton, and Terence S. Dermody

Summary and perspectives / Allan R. Brasier, Adolfo García-Sastre, and Stanley M. Lemon.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-283-03386-0

9786613033864

1-55581-556-1

OCLC:

609853118