Horizons in neuroscience research Volume 8 / Andres Costa, Eugenio Villalba, editors.

Format:

Book

Contributor:

Costa, Andres.

Villalba, Eugenio.

Series:

Horizons in Neuroscience Research

Horizons in Neuroscience Research ; v.8

Language:

English

Subjects (All):

Nervous system--Diseases.

Nervous system.

Neurosciences.

Physical Description:

1 online resource (237 p.)

Place of Publication:

New York : Nova Science Publishers, c2012.

Language Note:

English

Summary:

This compilation presents original study results on the leading edge of neuroscience research. Included in this volume is the contribution effects of the putamen to cognitive function, temporal lobe pathology in neurodegenerative disease, renin-angiotensin system modulation functions in CPu, and more.

Contents:

""HORIZONS IN NEUROSCIENCE RESEARCH VOLUME 8 ""; ""HORIZONS IN NEUROSCIENCE RESEARCH VOLUME 8 ""; ""Library of Congress Cataloging-in-Publication Data""; ""Contents""; ""Preface""; ""Regulation of Neuronal Morphology and Plasticity by Small GTP-Binding Proteins: Implications for Autism and Mental Retardation Disorders""; ""1Department of Pharmacological and Pharmaceutical Sciences, University of Houston.""; ""521 Science and Research Bldg 2, Houston, TX, US""; ""2Department of Biology and Biochemistry, University of Houston""; ""369 Science and Research Bldg 2, Houston, TX, US""

""3Department of Psychology, University of Houston""""126 Heyne Building, Houston, TX, US""; ""Abstract""; ""Introduction""; ""Autism Spectrum Disorders""; ""Small GTPases""; ""Rac, Cognition and Autism""; ""Regulation of Neuronal Morphology and Plasticity by Rac1""; ""Regulation of Learning and Memory by Rac1""; ""Fragile X Syndrome""; ""The Fmr1 Knockout Mice as an Animal Model for Fragile X Syndrome""; ""A Possible Link between Rac1 and Fragile X Syndrome""; ""Methodology""; ""Animals""; ""Generation of Rac1 Deficient Mice (Rac1 Mutant or Rac1 Knockout)""; ""Fmr1 Knockout Mouse""

""Isolation of Brain and Other Organs and Preparation of Hippocampal Slices""""Gross Morphology of the Hippocampus""; ""In Situ Hybridization""; ""Affinity Purification Assay""; ""Immunoblot Analysis""; ""Immunocytochemistry""; ""Neuronal Staining and Imaging""; ""Dendritic Spine Analysis""; ""Electrophysiological Recordings""; ""Behavioral Tests""; ""Open Field Testing""; ""Accelerating Rotating Rod Test""; ""Pre-Pulse Inhibition of Startle Response""; ""Hot Plate Test""; ""The Light-Dark Test""; ""The Elevated Plus Maze""; ""Fear Conditioning""; ""Morris Water Maze""; ""Data Analysis""

""Results""""Modulation of Rac1 Function by NMDA Receptors""; ""Critical Role of Rac1 in Neuronal Morphology""; ""Critical Role of Rac1 in Plasticity""; ""Critical Role of Rac1 in Learning""; ""Modulation of Neuronal Morphology and Plasticity by Rac1: A Role in Neurodevelopmental Disorders, Autism and Cognitive Disability""; ""Rac1 in Development""; ""Rac1 in Fragile X Syndrome Pathology""; ""Targeting Hyperactivation of Rac1 as a Novel Therapeutic Strategy for FXS""; ""Conclusion""; ""Acknowledgements""; ""References""

""Memory and Cognitive Dysfunctions in Alzheimer�s Disease Are Inextricably Intertwined with Neuroinflammation due to Aging, Obesity, Obstructive Sleep Apnea, and other Upstream Risk Factors""""Abstract""; ""1. Introduction""; ""2. Ageing and Inflammatory Stimulation""; ""3. Cigarette Smoking and Inflammatory Stimulation""; ""4. Obesity and Inflammatory Stimulation""; ""4A. Gut Inflammation in Obesity and Pro-inflammatory Cytokines""; ""4B. NSAIDs-induced Gut Inflammation""; ""5. Obstructive Sleep Apnea and Inflammatory Stimulation""; ""6. Snoring and Inflammation""

""7. Nucleus of the Solitary Tract""

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-61942-762-1