Autoimmunity versus carcinogenesis in tissue injury / Lawrence M. Agius.

Format:

Book

Author/Creator:

Agius, Lawrence M., author.

Series:

Immunology and Immune System Disorders

Language:

English

Subjects (All):

Carcinogenesis.

Physical Description:

1 online resource (188 pages)

Place of Publication:

New York : Nova Medicine & Health, [2021]

Summary:

"This book is a critical appraisal of the data and evidence available in literature of the relative roles of the immune response to neoplastic cells. An attempt has been made to render a better understanding of the various modes of impact of the immune response against tumors in general, particularly gliomas in some of the chapters. Autoimmune response is one mode of reactivity to native component cells within the body. Neoplastic transformation, on the other hand, critically necessitated the absence of an effective immune response to the transformed tumor cells in order for the lesion to grow and metastasize. This book is aimed towards a wider readership, but its particularly for oncologists and the various clinical and academic professionals that care for patients with cancer. It is especially meant to provide a clear exposition of known facts regarding the genesis and further development of neoplasms. Examples of some of the commoner lesions are accounted for"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Chapter 1

Predetermined Interplay of the Projected Malignant Transformation Step as Injury Non-Resolution

Abstract

Introduction

Cell Death Pathways

Identifiable Parameters of Progression

Dyshomeostasis

Pro-Apoptosis and Anti-Apoptosis

Performance Attributes

Conclusion

References

Chapter 2

Systems of Active Immune Suppression as Integral Malignant Transformation in Infiltrating Glioma Cells

Cytokines

Constitutional Factors

Conditioned Settings

Immune Response

Aberrant Immune Response

Chapter 3

Systems of Failure of Immune Response to Early Carcinogenesis Recharacterize Such Early Carcinogenesis

Incremental Evolution

Stages of Emergence

Developmental Waves

Modulation

Chapter 4

Mirror Images of Geometric Pre-Setting of the Infiltrating Edges of High-Grade Gliomas

Derivative Mechanisms

System Injury Profiles

Mirror Reproducibility

Performance Requisites

Chapter 5

Failed Tumor Immuno-Antigenicity Is Expressed Suppression of an Autoimmunity in Defining Immune Privilege Status of the Lesion

Interactivity

Interplay Dynamics

Variability of Antigenicity

Lymphocyte Non-Reactivity

Systems of Processing

Immune Priviliged Status

Chapter 6

Complex Effectiveness of General Immunity in Modulating the Specific Immune Response in Gliomas

Antigen Presentation

Immune System Specificity

Potential Dynamics

Series of Reactivities

Immune Response Increments

Biology of Immunity

Chapter 7.

Systems of Malignant Transformation as Integral Immune Nonresponse in Gliomagenesis

Injury to Glial Cells

Performance of Tumors

Induction of Maladaptation

Proportional Correlates

Infiltrated Brain Tissues

Chapter 8

Immunodominance as Complex Patterned Interplay of Antigen Quantitation Phenomena in Pressure Immunity

Demarcation Profiles of Antigenicity

Immunodominance

Antigenicity

Expressivity of Antigen

Antigen Identity

T Cell Specific Receptor

Chapter 9

Systems of Unstable Immunodominance of Antigen as Formulas for Central Immunosuppression in Tumor Cell Expansion

Tumor Dynamics

Immunosurveillance

Reformulations

Facilitation

Chapter 10

Failed Immunosurveillance as Failed Dendritic Cell Antigen Presentation-Substitution of Specific Tumor Antigenicity by Differentiation Associated Antigenicity

Tumorigenesis

Poor Antigenicity

Dynamics of Turnover of Lymphocytes

Contextual Considerations

Chapter 11

Projected Receptivity of Integral Gliomas to Malignant Transformation as Modeled by Dysfunctional Immunomodulation

Dimensional Theory

Immunomodulation

Permissive Dimensions

Constitutive Response

Performance Dynamics

Chapter 12

Tumor Cell Identity as Projected by Immunotoxins within Heterogeneity and Hierarchical Systems of Progression

Radiotoxicity

Susceptibility Patterns

Compound Influence

Chapter 13

Dimensions of Reproducible Malignant Transformation as Brain Infiltration by Glioma.

Abstract

Radio Labeling

Stabilized Tumor Dynamics

Brain Infiltration

Malignant Transformation

Chapter 14

Infiltrativeness Attributes Project Schemes of Etiology and Pathogenesis in Sequential Malignant Transformations in Given Individual Gliomas

Immune Non Response

Attempts at Control

Etiologic Measures

Infiltrativeness

System and Organ Predetermination

Causation and Etiology

Chapter 15

Progressively Persistent Tumor Cell Growth and Recurrence and Spread as Interplay Dynamics between Individual Neoplastic Cells

Summation Phenomena

System Manipulation

Tumor Growth Persistence

Chapter 16

Non-Response of the Immune System as Active Participant in Glioma Cell Genesis, Proliferation, and Spread in Normal Brain Tissues

Nonresponse

Pathogenic Pathways

Normal Infiltrated Tissues

Incremental Suppression

Neoantigenicity

Contextual Reformulations

Chapter 17

Pathways of Non-Resolution in Targeting Tumor Cells by the Immune Response

Contextual Antigen Restriction

System Co-Stimulation

Antigen Processing

Immunologic Memory

Molecular Targeting

Chapter 18

Tumor Cell Antigenicity as Performance Hierarchy of Equilibrating Interactivity of Systems of Receptivity and Activation of Lymphocyte Subsets

Antigen Derivation

Weak Antigenicity

Equilibrating Performance

Systems of Activation

Chapter 19

Systems of Primary Regional Reformation in Tumor Origin and Mechanics: Regional versus Field Operability.

Evolution

Reformulation

Pathobiology

Integration

System Schemes

Chapter 20

Formulation of an Integral Antitumor Immune Response

Intervention

Heterogeneity

Binding Mechanics

Emergence of Antigens

Pan-Immunity

Promotional Efforts

Chapter 21

Systems of Weak Immunogenicity as Originators of Early Spread and of Incremental Tumor Cell Growth and Proliferation

Systems Of Toxicity

Tumor Growth and Proliferation

Network Operabilities

Dimensions of Epitope Biology

Weak Immunogenicity and Metastases

Early Spread Potential

About the Author

Index

Blank Page.

Notes:

Description based on print version record.

ISBN:

1-5361-9660-6

OCLC:

1250090269