2 options
The Construction of Analogy-Based Research Programs The Lock-and-Key Analogy in 20th Century Biochemistry Rebecca Mertens
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Mertens, Rebecca <p>Rebecca Mertens, Universität Bielefeld, Deutschland</p>, Author.
- Series:
- Science studies (Bielefeld, Germany)
- Science Studies
- Language:
- English
- Subjects (All):
- Lock-key Hypothesis.
- Analogy.
- Research Program.
- Molecular Biology.
- Biochemistry.
- History of Science.
- Science.
- Medicine.
- Philosophy of Science.
- Sociology of Science.
- Life Sciences.
- History.
- Local Subjects:
- Lock-key Hypothesis.
- Analogy.
- Research Program.
- Molecular Biology.
- Biochemistry.
- History of Science.
- Science.
- Medicine.
- Philosophy of Science.
- Sociology of Science.
- Life Sciences.
- History.
- Physical Description:
- 1 online resource (225 pages).
- Edition:
- 1st ed.
- Other Title:
- Mertens, The Construction of Analogy-Based Research Programs The Lock-and-Key Analogy in 20th Century Biochemistry
- Place of Publication:
- Bielefeld transcript Verlag 2019
- Language Note:
- In English.
- Biography/History:
- Rebecca Mertens (PhD), born in 1984, is a postdoctoral researcher in the history and philosophy of science at Bielefeld University. She works on the role of analogies, models and forms of comparison in the history of molecular genetics and is a member of the collaborative research program »Practices of Comparison: Ordering and Changing the World«.
- Summary:
- When the German chemist Emil Fischer presented his lock-and-key hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity.Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling.
- Contents:
- Frontmatter 1 Table of contents 5 Preface 7 1 The lock-and-key analogy and its influence on 20th century biochemistry 9 2 The lock-and-key analogy in Emil Fischer's program on sugar fermentation, 1890-1907 39 3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930 77 4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960 133 5 Lock-and-key-based modeling and its influence on the development of biochemical research programs 173 6 Concluding remarks on the construction of analogy-based research programs 199 Literature 205
- Notes:
- Thesis (doctoral)--Universität Bielefeld, 2018.
- ISBN:
- 9783839444429
- 383944442X
- OCLC:
- 1096231434
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.