Biochemical mechanisms of aluminium induced neurological disorder / Touqeer Ahmed.

Format:

Book

Contributor:

Ahmed, Touqeer, editor.

Language:

English

Subjects (All):

Aluminum--Toxicology.

Aluminum.

Aluminum--Physiological effect.

Neurotoxicology.

Neurotoxic agents.

Physical Description:

1 online resource (196 pages)

Edition:

1st ed.

Place of Publication:

UAE : Bentham Science Publishers, [2021]

Summary:

Aluminium is a chemical element present in earth's crust and it is a known environmental toxin which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimer's disease. Biochemical Mechanisms of Aluminium Induced Neurological Disorders explains the association of aluminium with neurological disorders. The book introduces the reader to sources of aluminium exposure, followed by an explanation of pharmacokinetics of aluminium and the different biochemical pathways that cause neurological effects. Chapters cover the typical mechanisms associated with aluminium neurotoxicity such as synaptic impairment as well as recent topics of interest such as the role of aluminum in impairing blood-brain barrier functions. Separate chapters which cover clinical evidence of aluminium toxicity and its management are also included in the book. Biochemical Mechanisms of Aluminium Induced Neurological Disorders is a concise, yet informative reference on the subject of aluminium neurotoxicity for all readers, whether they are students of biochemistry, pharmacology and toxicology, clinical neurologists, environmentalists interested in metal pollution or general readers who want to learn about the toxic effects of aluminium in humans.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

List of Contributors

Biochemical Mechanisms of Aluminium and Other Metals Exposure, Their Brain Entry Mechanisms, Effects on Blood Brain Barrier and Important Pharmacokinetic Parameters in Neurological Disorders

Sara Ishaq1, Amna Liaqat1, Armeen Hameed1 and Touqeer Ahmed1,*

INTRODUCTION

Metals and their Evolution in Biological Processes

Metals Induced Neurotoxicity

ABSORPTION OF TOXIC METALS IN THE BRAIN

Transport of Toxic Metals Across Blood Brain Barrier

Transport of Toxic Metals Across Blood Cerebrospinal Fluid Barrier

MAPPING BRAIN REGIONS WITH TOXIC METALS DISTRIBUTION

Aluminium

Arsenic

Lead

Mercury

Cadmium

TOXIC METALS WITH MULTIPLE TOXICOKINETIC ASPECTS

Bio-absorption

Mitochondrial Dysfunction

Effects of Metals Induced Toxicity on Neurotransmission

Cellular Oxidative Stress Induction by Toxic Metals

Events of Cellular Signaling in the Nervous System

METAL EXCRETION FROM THE BODY

DISEASE MANIFESTATION AS AN OUTCOME TO TOXIC METAL EXPOSURE

Alzheimer's Disease (AD)

Parkinson's Disease (PD)

Amyotrophic Lateral Sclerosis (ALS)

Multiple Sclerosis (MS)

Synergistic Effects of Metals Mixture in Brain

CONCLUDING REMARKS

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

ABBREVIATIONS

REFERENCES

Co-Exposure of Aluminium with other Metals Causes Neurotoxicity and Neurodegeneration

Abida Zulfiqar1, Ghazal Iqbal1 and Touqeer Ahmed1,*

1. ACCUMULATION OF METALS IN THE BRAIN AND COGNITIVE IMPAIRMENT

2. METALS AND HFD INDUCED OXIDATIVE STRESS IN COGNITIVE IMPAIRMENT

3. PREVALENCE AND CURRENT SCENARIO OF COGNITIVE IMPAIRMENT IN WORLDWIDE

4. ALUMINIUM NEUROTOXICITY AND ITS EFFECT ON NEUROTRANSMISSION

5. MOLECULAR BASIS OF ALUMINIUM NEUROTOXICITY.

Aluminium and Cell Signaling

6. THE NEUROTOXICITY INDUCED BY METAL MIXTURE

7. HARMFUL EFFECTS OF CHOLESTEROL IN ASSOCIATION WITH METAL EXPOSURE

8. ROLE OF APOE GENOTYPE IN COGNITIVE IMPAIRMENT IN ASSOCIATION WITH METAL EXPOSURE

Evidence For The Link Between ApoE And Metals

9. ROLE OF TOTAL TAU IN COGNITIVE IMPAIRMENT (IN ASSOCIATION WITH METAL EXPOSURE)

10. ROLE OF AMYLOID Β-42 IN COGNITIVE IMPAIRMENT (IN ASSOCIATION WITH METAL EXPOSURE)

LIST OF ABBREVIATIONS

Role of aluminium in Post-Translational Modifications and Neurological Disorders

Saadia Zahid1,*, Sanila Amber1 and Fatima Javed Mirza1

1. ALUMINIUM MEDIATED OXIDATIVE STRESS

2. ALUMINIUM INDUCED NEUROTOXICITY

3. ALUMINIUM AND NEUROLOGICAL DISORDERS

3.1. Aluminium and Alzheimer's Disease

3.2. Aluminium and other Neurological Disorders

4. POST TRANSLATIONAL MODIFICATIONS

5. ALUMINIUM AND POST TRANSLATIONAL MODIFICATIONS

5.1. Aluminium and Phosphorylation

5.2. Aluminium and Methylation

5.3. Aluminium and Protein Oxidation

5.4. Aluminium and Ubiquitination

Effect of Aluminium on Synaptic Plasticity

Syeda Mehpara Farhat1,*

Effects of Al Accumulation on Synaptic Plasticity

Effect of Al on Ca+2 Channel and Ca+2 Signaling

Effect of Aluminium on Receptors Involved in Synaptic Plasticity

Effect of Aluminium on Signaling Pathways Involved in Synaptic Plasticity

Effect of Aluminium on Ca+2-CaMKII Signaling Pathway

Effect of Aluminium on Glutamate-nitric Oxide-cyclic GMP Signaling Pathway

Effect of Aluminium on BDNF Modulated Signaling Pathways.

Effect of Aluminium on PLC Signaling Pathway

Aluminium and other Metals Exposure Cause Neurological Disorders: Evidence from Clinical/ human Studies

Zehra Batool1, Laraib Liaquat2, Tuba Sharf Batool3, Rida Nisar4 and Saida Haider5,*

NEUROLOGICAL DISORDERS INDUCED BY HAZARDOUS METALS ALUMINIUM

Mechanism of Aluminium -Induced Neurotoxicity

Aluminium-Induced Neurological Disorders: Clinical Evidences

ARSENIC

Mechanism of Arsenic-Induced Neurotoxicity

Arsenic-Induced Neurological Disorders: Clinical Evidences

MERCURY

Mechanism of Mercury-Induced Neurotoxicity

Mercury-Induced Neurological Disorders: Clinical Evidences

LEAD

Mechanism of Lead-Induced Neurotoxicity

Lead-Induced Neurological Disorders: Clinical Evidences

CADMIUM

Mechanism of Cadmium-Induced Neurotoxicity

Cadmium-Induced Neurological Disorders: Clinical Evidences

NEUROLOGICAL DISORDERS INDUCED BY ESSENTIAL METALS IRON

Physiological Role of Iron

Mechanism of Iron-Induced Neurotoxicity

Iron-induced Neurological Disorders: Clinical Evidences

CHROMIUM

Physiological Role of Chromium

Mechanism of Chromium-Induced Neurotoxicity

Chromium-Induced Neurological Disorders: Clinical Evidences

COBALT

Physiological Role of Cobalt

Mechanism of Cobalt-Induced Neurotoxicity

Cobalt-Induced Neurological Disorders: Clinical Evidences

COPPER

Physiological Role of Copper

Mechanism of Copper-Induced Neurotoxicity

Copper-Induced Neurological Disorders: Clinical Evidences

MANGANESE

Physiological Role of Manganese

Mechanism of Manganese-Induced Neurotoxicity

Manganese-Induced Neurological Disorders: Clinical Evidences

NICKEL

Physiological Role of Nickel.

Mechanism of Nickel-Induced Neurotoxicity

Nickel-induced Neurological Disorders: Clinical Evidences

Developmental Toxicity of Aluminium and other Metals: Areas Unexplored

Laraib Liaquat1,2, Zehra Batool3,* and Saida Haider1

ALUMINIUM

Teratogenic Nature of Aluminium

Mechanism of Teratogenic Activity

Teratogenic Nature of Arsenic

Teratogenic Nature of Lead

Teratogenic Nature of Mercury

Teratogenic Nature of Cadmium

URANIUM

Teratogenic Nature of Uranium

LITHIUM

Teratogenic Nature of Lithium

Teratogenic Nature of Manganese

Teratogenic Nature of Cobalt

Subject Index

Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print record.

Includes bibliographical references.

Other Format:

Print version: Ahmed, Touqeer Biochemical Mechanisms of Aluminium Induced Neurological Disorders

ISBN:

9781681088839

1681088835

OCLC:

1292358560