The Niakhar high-titer measles vaccine trial, 1987-1990 / Michel Garenne, in collaboration with Odile Leroy [and four others].

Format:

Book

Author/Creator:

Garenne, Michel, author.

Contributor:

Leroy, Odile, contributor.

Language:

English

Subjects (All):

Vaccination.

Physical Description:

1 online resource (325 pages)

Edition:

1st ed.

Place of Publication:

Newcastle upon Tyne, England : Cambridge Scholars Publishing, [2020]

Summary:

This study reports the methodology and findings of a randomized controlled vaccine trial conducted in Senegal in 1987-1990. Two high-titer measles vaccines of different strains (Edmonston-Zagreb and Schwarz) were compared with a standard vaccine (the Schwarz strain) among infants aged 5 to 10 months. Comparison focused on clinical efficacy, immunogenicity and safety. Although both high-titer vaccines induced an immunogenic response even when given at the age of 5 months, they induced a lower level of antibodies, had more vaccine failures, and were not safe, inducing an excess mortality within two years after vaccination. Scientific, ethical and political issues linked with such negative findings are discussed in this book.

Contents:

Intro

Dedication

Table of Contents

List of Figures and Charts

Foreword

Summary of Main Findings

Preface

Acknowledgments

Chapter 1

Chapter 2

Chapter 3

Chapter 4

Chapter 5

Chapter 6

Chapter 7

Chapter 8

Chapter 9

Chapter 10

Chapter 11

References

Annexes

Index.

Notes:

Description based on print version record.

Description based on publisher supplied metadata and other sources.

ISBN:

1-5275-4994-1

1-5275-4869-4

OCLC:

1153767993