1 option
Gastric peritoneal carcinomatosis : principles of surgery and treatment options / Fernando López Mozos, Roberto Martí Obiol, editors.
- Format:
- Book
- Series:
- Cancer Etiology, Diagnosis and Treatments
- Language:
- English
- Subjects (All):
- Stomach--Cancer.
- Stomach.
- Physical Description:
- 1 online resource (274 pages)
- Place of Publication:
- New York : Nova Science Publishers, [2021]
- Summary:
- "Gastric cancer is the fourth most common cancer in the world. Most gastric cancers are diagnosed in advanced stages, and the prognosis remains poor. The 5-year survival rate is 40-60% in eastern countries and around 25% in the west. Among advanced gastric cancer cases, peritoneal implantation is one of the most common forms of metastasis and around 14% of cases present peritoneal metastases at initial diagnosis, presenting a survival of 3-6 months. Until the early 1990s it was considered a terminal disease. But today these patients have some opportunities to be treated with curative intent or to prolong their life. Although the prognosis remains poor, there are some treatment options including cytoreductive surgery, neoadjuvant therapy, and some forms of intraperitoneal chemotherapy with or without hyperthermia. These are aggressive treatments, so we must be careful when selecting patients. Imaging and preoperative staging are also crucial in selecting patients for appropriate treatment. The surgical technique is described and a detailed demonstration video is available in the e-book version. New forms of treatment such as PIPAC and new scientific advances and future perspectives are discussed. This book is an update on this topic and attempts to provide an overview for all medical personnel involved in the treatment of these patients"-- Provided by publisher.
- Contents:
- Intro
- Contents
- Foreword
- Acknowledgments
- Chapter 1
- Epidemiology of Gastric Cancer
- Abstract
- Introduction
- References
- Chapter 2
- Role of Imaging in Peritoneal Surface Malignancies
- Computed Tomography (CT) and TNM
- CT Protocol
- Tumor Staging
- Node Staging (N)
- Distant Metastasis (M)
- Peritoneal Carcinomatosis
- Peritoneal Cancer Index
- Other Imaging Modalities
- Conclusion
- Chapter 3
- Diagnosis and Staging in Advanced Gastric Cancers
- Clinical Presentation and Diagnosis
- Symptoms
- Signs
- Laboratory Studies
- Endoscopy
- Diagnosis of Gastric Adenocarcinoma
- Histopathology
- Molecular Diagnosis
- EBV-Positive and MSI High
- GS and CIN
- Implications for Therapy
- Diagnosis of Inherited Cancer Syndromes
- GIST
- GNET
- Clinical and Pathologic Staging of Gastric Adenocarcinoma
- TNM Staging
- Tumor Stage
- Node and Metastasis Staging
- Computed Tomography
- Nuclear Medicine
- Magnetic Resonance Imaging
- Staging Laparoscopy
- Peritoneal Lavage
- Molecular Assays
- Image Sources
- Chapter 4
- Histopathological and Molecular Classifications of Gastric Cancer
- Histopathological Classification of Gastric Cancer
- Lauren's Classification
- The WHO Classification
- Prognostic Relevance of the Histopathological Classifications
- Immunohistochemical Studies and Ancillary Techniques
- Differential Diagnosis With Metastatic Lobular Breast Carcinoma
- Molecular Classification of Gastric Cancer
- The Cancer Genome Atlas (TCGA) Classification
- The Asian Cancer Research Group (ACRG)
- Clinical Relevance of Molecular Classifications
- Chapter 5.
- Patient Selection and Preoperative Considerations
- Patient Selection
- Preoperative Considerations
- Preoperative Information and Psychological Counselling
- Nutritional Assessment and Optimization
- Cessation of Smoking and Alcohol Consumption
- Hematologic Support and Physical Exercise
- Anesthetic Assessment
- Bowel Preparation
- Fasting
- Chapter 6
- Gastric Cancer, the Multidisciplinary Approach
- The Peri-Operative Approach
- The Current Peri-Operative Approach
- The Role of Pre-Operative Chemoradiation
- Immunotherapy for Gastric Cancer
- Other Experimental Approaches
- Considerations for the Elderly Population
- Chapter 7
- Pathophysiologic Basis, Principles and Technique of Cytoreductive Surgery (CRS) for Gastric Cancer Peritoneal Metastases
- The Influence of Tumor Biology in the Natural History of Gastric Cancer
- Clinical Manifestations of Gastric Cancer Peritoneal Metastases
- Preoperative Evaluation and Patient Selection for CRS and HIPEC in Gastric Cancer Peritoneal Metastases
- Response to Neoadjuvant Systemic Chemotherapy
- Presence of Other Metastatic Sites
- Extent and Distribution of Peritoneal Metastases
- Completeness of Cytoreduction Score
- Application of Peritonectomy Procedures and Other Surgical Techniques during Cytoreductive Surgery for Peritoneal Metastases of Gastric Cancer Origin
- Anterior Parietal (Epigastric) Peritonectomy and Resection of Previous Incision Sites
- Anterolateral Peritonectomy, Greater Omentectomy and Radical Gastrectomy With or Without Splenectomy
- Stripping of the Omental Bursa
- Gastrectomy and Lymphadenectomy
- Segmental Bowel Resections.
- Pelvic Peritonectomy Techniques and Complete Peritoneal Stripping Of The Cul-De-Sac
- Cytoreduction of the Small Bowel and Its Mesentery
- Segmental Ureter Resection and Reconstruction
- Salpingo-Oophorectomy
- Gastrointestinal Reconstruction After Gastrectomy
- Postoperative Complications after Cytoreductive Surgery for Gastric Cancer Peritoneal Metastases
- The Role of Minimally Invasive Surgery (MIS) in the Surgical Treatment of Gastric Cancer Peritoneal Metastases
- The Moises Broggi Hospital Experience (Peritoneal Carcinomatosis Program of Catalonia) of CRS and HIPEC for Gasric Cáncer
- List of Videos Attached to the Chapter on CRS Techniques in Gastric Cancer Associated with Peritoneal Metastases
- Video 1: Gastric Cancer with Synchronous PM (Male Patient)
- Video 2: Metachronic Gastric PM (Female Patient). Previous Gastrectomy
- Video 3: Gastric Cancer with Synchronous PM (Female Patient)
- Video 4: Iterative CRS+HIPEC in Recurrent Gastric PM
- Chapter 8
- Role of Intraperitoneal Chemotherapy in Gastric Cancer
- Rationale for Intraperitoneal Chemotherapy in GC
- HIPEC
- HIPEC for Treatment of established PM from GC
- HIPEC as Neoadjuvant Treatment
- HIPEC as Prophylactic or Adjuvant Treatment
- HIPEC as Palliative Treatment
- EPIC
- NIPEC
- Extensive Intraoperative Peritoneal Lavage (EIPL)
- NIPS
- PIPAC
- Chapter 9
- Current Role of PIPAC in Peritoneal Metastases of Gastric Origin
- Rationale of PIPAC
- Surgical Technique for PIPAC
- Indications
- Treatment Regimen and Assessment of Response
- Role of PIPAC in Peritoneal Metastases of Gastric Cancer. Current Evidence
- Future Perspectives
- Chapter 10
- Scientific Advances and Future Perspectives
- Introduction.
- Emerging Screening and Diagnostic Tools in Gastric Cancer With Peritoneal Metastasis
- Novel Peritoneal and Serum Biomarkers
- Gastric Peritoneal Metastasis Predictive Models and Advances in Traditional Diagnostic Modalities
- Fluorescence-Guided Intraoperative Detection of Peritoneal Metastasis
- Considerations for Re-Staging after Intraperitoneal Therapy
- Multimodality Therapy for Metastatic Gastric Cancer - Prospects and Recent Advances
- Total Neoadjuvant Therapy
- Immunotherapy
- Immune Checkpoint Blockade
- Adoptive T-Cell Therapy
- Immunotoxin Therapy
- Cancer Vaccines
- Nanoparticle Drug Delivery System
- Photodynamic Diagnosis and Therapy
- Cancer Gene Therapy
- Near-Infrared Photoimmunotherapy
- Cell‐Free and Concentrated Ascites Reinfusion Therapy (CART)
- The Future Perspective - Tissue Models of Peritoneal Metastasis from Gastric Cancer and Ongoing Clinical Research
- About the Editors
- Index
- Blank Page
- Blank Page.
- Notes:
- Description based on print version record.
- ISBN:
- 1-5361-9602-9
- OCLC:
- 1250088973
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