Epigenetics : Beyond the Genetics and Medicine / Sevgi Durna Daştan and Nazan Yurtcu, editors.

Format:

Book

Contributor:

Durna Daştan, Sevgi, editor.

Yurtcu, Nazan, editor.

Series:

Genetics--research and issues series.

Genetics - Research and Issues Series

Language:

English

Subjects (All):

Epigenetics.

Medical genetics.

Disease susceptibility.

Physical Description:

1 online resource (354 pages)

Edition:

First edition.

Place of Publication:

New York : Nova Science Publishers, Inc., [2022]

Summary:

"Epigenetics refers to the study of changes in organisms that are caused by modifications of gene expression instead of alteration of the genetic code itself. This volume includes 30 chapters that explore epigenetics from a variety of perspectives, including the role of epigenetics in aging, cancers, fetal brain development, epilepsy, and more"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Chapter 1

The Concept of Epigenetics

Abstract

Introduction

Epigenetics and Its Importance

Epigenetic Regulations

Mechanisms that Directly Control Gene Expression

Mechanisms that Indirectly Control Gene Expression

Epigenome and Epigenetics

Epigenetic Diseases and Cancer

Cancer and Epigenetics Therapy

The Relationship between Environment, Nutrition, Aging, and Epigenetics

Conclusion

References

Chapter 2

The Relationship between Epigenetics and Diseases/Disorders

X Chromosome Inactivation

Genomic Stigma

Autoimmune Diseases

Down Syndrome

CHARGE Syndrome

DiGeorge Syndrome

Chapter 3

The Role of DNA Methylation and Histone Modifications in Oncogenesis

Epigenetic Mechanisms

Epigenetic DNA Modifications

Histone Modifications

Methylation of DNA and Histones in Cancer

Chapter 4

Epigenetic Effects of MicroRNAs in Oncogenesis

DNA Methylation

RNA Interference (RNAi)

MicroRNA

MicroRNAs and Cancer

miRNAs and Epigenetics

miRNAs Regulated by Epigenetic Mechanisms and Their Expression and the Associated Cancers

miR-9

miR-34 (A and B/C)

miR-124

miR-137

miR-148

Let-7a-3

Epi-miRNA

Chapter 5

The Concepts of Epigenomics and Cell Epigenomes

Abbreviations

Epigenome Characterization

The Profiling Whole Genome Methylation Models

Analysis of the Genome-wide Histone Modification Patterns

A New Frontier in Epigenomics: High-Throughput Sequencing

Epigenomic Marks

Epigenome-Wide Association Studies (EWAS)

Future Perspectives for Epigenomics

References.

Chapter 6

The Role of Epigenetics in Cancers

Human Epigenome Project

International Human Epigenome Consortium

Epigenetic Mechanisms in Cancer Cells

Role of DNA Methylation in Cancer Cells

Role of Histone Modifications in Cancer Cells

Nucleosome Remodeling in Cancer Cells

Micro RNAs (miRNAs) in Cancer Cells

Chapter 7

Epigenetics and Microbiota

The Human Microbiota

The Gut Microbiota

DNA Methylation and Microbiota

Histone Modifications and Microbiota

Noncoding RNA and Microbiota

Chapter 8

The Role of Non-Coding RNAs in Epigenetic Mechanisms

Non-Coding RNAs (ncRNAs)

MicroRNAs (miRNAs)

Long Non-Coding RNAs (lncRNAs)

PIWI-Interacting RNAs (piRNAs)

Importance of ncRNAs in Epigenetic Mechanisms

Role of ncRNAs in Cancer

The Function of ncRNAs in Other Diseases

Chapter 9

General Overview of the Current Methodology in Epigenetics Research

Chromatin Immunopresipitation (ChIP)

3C Chromosome Conformation Capture

Southern Blot

Microarray

Restriction Enzyme PCR

Methylation-Specific PCR (MSP)

Methylation-Sensitive Single-Nucleotide Primer Extension

Bisulfite DNA Sequence Analysis

Epigenetic MR

Advantages of the Epigenetic MR Method

Disadvantages of the Epigenetic MRI

RNA-Induced Silencing

Chapter 10

Computational Modeling of Epigenetics

Data Sources for Epigenetic Research

Computational Tools for Epigenetic Research

Computational Examination of DNA Methylation

Computational Examination of Histone Alteration.

Conclusion

Chapter 11

The Role of Epigenetics in Aging

Theoretical Perspectives

The Aging and Chromatin Structure

The Nucleosome Structure and Aging

Aging-Related Post-Translational Modifications (PTMs) of Histone Proteins

Aging-Related Chromatin Modifier Expressions

Telomers in Regard to Aging

Chapter 12

Epigenetics and Familial Mediterranean Fever

Epigenetics and FMF

Chapter 13

Epigenetics in Neurobiological and Neurobehavioral Diseases

Epigenetic Mechanisms in Autism and Related Disorders

Epigenetic Mechanisms in Neurodegenerative Disorders

Epigenetic Mechanisms in Psychotic Disorders

Epigenetic Mechanisms in Mood Based Disorders

Epigenetic Mechanisms in Addiction

Epigenetic Mechanisms in Anxiety, Stress, and Fear Disorders

Epigenetic Mechanisms in Circadian Rhythm

Chapter 14

The Role of Epigenetics in Fetal Brain Development

Definition of Epigenome

Brain Development Based on Experience

Relation of Epigenetic Programming Mechanisms with Maternal Care

Exposure to Environmental Pollutants before Birth and Its Impact on Health and Epigenetics Dysregulation

Neural Stem Cell Fate under Epigenetic Control Mechanisms

Inhibitory Effect of Signaling Molecules on Glial Genes to Promote Non-Glial Cells

Activation of Neuronal and Glial Biogenesis

The Implication of ncRNAs during Early Neural Development

Infant Outcomes of Maternal Prenatal Stress

Epigenetic Changes due to Hypoxic Ischemic Damage

Postnatal Epigenetic Effects

Chapter 15

Epilepsy and Epigenetics.

Abstract

Major Epigenetic Mechanisms

Histonic Modifications

RNA Based Mechanisms (Non-Coding RNA)

Epilepsy and Epigenetic Mechanisms

Epigenetic Mechanisms Affected in Epilepsy

DNA Methylation in Epilepsy

Histonic Modifications in Epilepsy

Non-Coding RNAs in Epilepsy

Chapter 16

Epigenetics and Cardiovascular Diseases

RNA-Based Mechanisms

Chapter 17

Epigenetics and Obesity

Epigenetic Effects of Nutrition

Definition and Etiology of Obesity

Epigenetic Mechanisms Affecting Obesity

Non-Coding RNAs

Chapter 18

Epigenetics and Diabetes

The Role of Epigenetic Changes in the Development of Diabetes Mellitus

Post-Translational Histone Modifications

RNA Methylation and Expression

Metabolic Memory

Chapter 19

The Role of Epigenetics in Osteoporosis

Osteoporosis with its Epigenetic Aspect

Osteoporosis and Epigenetic Drugs

Chapter 20

The Role of Epigenetics in Osteoarthritis

Pathogenesis of Osteoarthritis

Role of Epigenetics in OA

DNA Methylation in OA

Histon Modifications in OA

Non-Coding RNAs in OA

Chapter 21

Effect of Epigenetic Factors on Degenerative Disc Disease

Structure of the Intervertebral Disc

Pathogenesis

Etiology

Gene Polymorphism.

Collagen Gene Polymorphisms

Type 1 Collagen Gene Polymorphism

Type 9 Collagen Gene Polymorphism

Type 11 Collagen Gene Polymorphism

Aggrecan Gene Polymorphism

Vitamin D Receptor (VDR) Gene Polymorphism

Matrix Metalloproteinase Gene Polymorphisms

MMP-1 Gene Polymorphism

MMP-2 (Gelatinase-A) Gene Polymorphism

MMP-3 (Stromelysin 1) Gene Polymorphism

MMP-9 Gene Polymorphism

MMP-14 Gene Polymorphism

ADAMTS (Aggrecanase) Gene Polymorphism

Epigenetic Mechanism

Chapter 22

Epigenetics in Scoliosis

Historical Development in Scoliosis Clinic

Biomechanical Causes in Scoliosis

Genetic Studies for Scoliosis Pathogenesis

Chapter 23

Epigenetics in Endometriosis and Endometrial Cancer

Endometrial Cycle

Menstrual Cycle

Endometriosis

Endometrial Cancer

Treatment of the Endometrial Cancer

Chapter 24

Epigenetics in PCOS

Chapter 25

Epigenetics and Preeclampsia

Epigenetic Alterations

Histone Modification

PE and Epigenetic Changes

PE and DNA Methylation

PE and Histone Modification

PE and miRNAs

Maternal Blood Epigenetic Marks in Preeclampsia

Chapter 26

Epigenetics and Pain

Epigenetic Mechanisms in Chronic Pain

Epigenetic Mechanisms in Neuropathic Pain

Chapter 27

Epigenetics and Connective Tissue Diseases

Systemic Lupus Erythematosus (SLE)

Sjogren's Syndrome (SS).

Systemic Sclerosis (SSc).

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Other Format:

Print version: Daştan, Sevgi D. Epigenetics: Beyond the Genetics and Medicine

ISBN:

9798886973495

OCLC:

1349279545