The ubiquitin proteasome system in the central nervous system : from physiology to pathology - 2008 update / Mario Di Napoli and Cezary Wojcik, editors.

Format:

Book

Contributor:

Di Napoli, Mario (Physician)

Wójcik, Cezary, 1968-

Series:

Biochemistry research trends series.

Biochemistry research trends series

Language:

English

Subjects (All):

Ubiquitin.

Central nervous system--Physiology.

Central nervous system.

Central nervous system--Pathophysiology.

Physical Description:

1 online resource (578 p.)

Edition:

[Updated ed.].

Place of Publication:

New York : Nova Science Publishers, Inc., c2010.

Language Note:

English

Summary:

The ubiquitin-proteasome field has experienced a breathtaking development from obscure origins in the late 1970s and early 1980s, through a maturing but a well circumscribed field in the 1990s, into a huge, and ever growing interdisciplinary area in the 2000s. Nearly 7% of all genes encoded by the human genome comprise elements of the ubiquitin-proteasome system (UPS), making it the most complex of all biochemical pathways. This complexity depends mostly on its hierarchical organization, where the 20S proteasome is the common machinery mediating total or partial degradation of practically any protein in our body. Proteolysis via the UPS is a rapid and effective method of degrading a specific protein at a specific time, and in many cases a protein is degraded only in response to a particular cellular signal or event. Controlling where and when a protein is degraded can enhance the specificity and timing of proteolysis, generate asymmetry and maintain sub-compartments. The 24 articles of this updated collection describe the authors' research, from medical and academic research facilities worldwide, on various aspects of the UPS in nervous system. The articles discuss research of the UPS in connection with many important aspects of nervous system development, physiology and diseases, ranging from basic sciences to more specific topics useful for both basic neuroscientists and active clinical neurologists in an attempt to present in one place a cross-field, translational reference in a format accessible to a practicing neurologist as well as to a neuroscientist. Due to the inherent nature of the topic, the book has crossed over discipline barriers, engaging an amazing international team of specialists from disparate fields to conduct the readers across the principal avenues of the UPS physiology and pathology in the nervous system.

Contents:

Mechanisms and substrate specificity of desumoylating enzymes / Miklos Bekes and Guy S. Salvesen

Crosstalk between the ubiquitin and sumo pathways / Huaiyu Sun and Tony Hunter

The roles of the ubiquitin-proteasome system in the control of circadian clocks / Qun He, Chi-Tai Tang, and Yi Liu

Roles of the ubiquitin proteasome pathway in transcriptional regulation / Thomas G. Gillette

Role and function of the ubiquitin-proteasome system in neural stem and progenitor cells / Cord Naujokat and Tomo Saric

Ubiquitin/proteasome system in mitotic and mitotic-like regulation during brain development and pathology / Jacek Z. Kubiak and Mark A. Smith

Role of synapse-localized E3 ubiquitin ligase in regulating neural transmission / Ikuko Yao, Hiroshi Ageta, Mitsutoshi Setou

Regulation of GABAA receptor synaptic expression by the ubiquitin proteasome system / Richard S. Saliba and Stephen J. Moss

Roles of the ubiquitin proteasome system in the development and function of the neuromuscular junction / Zhonghua Lu, Mary P. Heyer, and Guoping Feng

The interrelationship between reactive oxygen species (ROS) and proteasome inhibition as inducers of neuronal cell death / Luena Papa and Patricia Rockwell

The role of the ubiquitin proteasome system in proinflammatory cytokine signaling in the central nervous system / Kyungsun Choi, Jungsul Lee, and Chulhee Choi

Role of immunoproteasomes in ageing and neurodegenerative diseases / Michele Mishto ... [et al.]

Glia, inflammasomes, and proteasomes in neurodegenerative and autoimmune diseases / Bosede Adenekan and Maria E. Figueiredo-Pereira

The ubiquitin-proteasome system and the aggresome-autophagy pathway : intersecting mechanisms of misfolded protein clearance in neurodegenerative disease / James A. Olzmann, Lih-Shen Chin, and Lian Li

Novel functions of parkin / Antoine Duquette and Edward A. Fon

Validity of targeting the ubiquitin proteasome system in the establishment of new animal models of Parkinson's disease / Anne M. Landau

The interrelationship between autophagy and the ubiquitin proteasome system in ALS models / Nobutoshi Morimoto and Koji Abe

The role of the ubiquitin proteasome system in the pathogenesis of Huntington's disease and other polyglutamine disorders / Mathieu Lesort and Gail V.W. Johnson

The ubiquitin protesome system dysfunction and protein aggregation after brain ischemia / Bingren Hu and Chunli Liu

Transient cerebral ischemia triggers a dramatic activation of small ubiquitin-like modifier (sumo) conjugation : possible significance / Wei Yang, Huaxin Sheng, and Wulf Paschen

Ubiquitination, sumoylation, and de-sumoylation of HIF-1 : a key molecule involved in brain development and adaptation to hypoxia in adult brain / Sui Zhang, Jinke Cheng, and Edward T.H. Yeh

Tuning nodal signaling via the ubiquitin-proteasome system / Yan Xiao and Chenzhong Kuang

The role of ubiquitin proteasome system and proteasome inhibitors in brain tumors / Jan Styczynski.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-61324-045-7