Human genome : components, structural/functional disorders and ethical issues / Tomeo Caccavelli, editor.

Format:

Book

Contributor:

Caccavelli, Tomeo.

Series:

Genetics--research and issues series.

Genetics - Research and Issues

Language:

English

Subjects (All):

Human genome--Analysis.

Human genome.

Human genetics.

Human chromosomes.

Physical Description:

1 online resource (199 p.)

Place of Publication:

New York : Nova Biomedical, c2013.

Language Note:

English

Summary:

The human genome is the complete set of human genetic information, stored as DNA sequences within the 23 chromosome pairs of the cell nucleus and in a small DNA molecule within the mitochondrion. In this publication, the authors present topical research in the study of the components, structural and functional disorders; and ethical issues of the human genome. Topics discussed include critical events in the pathobiology of cancer and the compilation of major biomarkers enabling improved diagnosis; and the evolution of human genome analysis and its impact on disease diagnosis and molecular diag

Contents:

""HUMAN GENOME""; ""HUMAN GENOME""; ""Library of Congress Cataloging-in-Publication Data ""; ""Contents ""; ""Preface ""; ""Chapter I Cytogenetics to Genomics in Cancer Diagnostics ""; ""Abstract ""; ""Introduction ""; ""Background ""; ""Classification by Site of Origin ""; ""Classification by Tissue Types ""; ""Classification by Grade ""; ""Classification by Stage ""; ""Diagnostic Techniques in Cancer ""; ""Cancer Diagnostic Techniques in Clinical Practice Today ""; ""Pap Test ""; ""Sputum Analysis and Bronchial Washing Analysis ""; ""Endoscopy ""; ""Blood Tests ""; ""Imaging Studies ""

""Genetic Analysis in Cancer Diagnostics """"Chromosomal Analysis ""; ""Karyotyping ""; ""Analysis ""; ""Fluorescence in Situ Hybridisation (FISH)""; ""Array Painting ""; ""Real-Time Quantitative PCR ""; ""Multiplex PCR ""; ""Sequencing Approaches ""; ""Sanger Sequencing ""; ""Second Generation/Next Generation Sequencing (NGS) ""; ""Life Technologies: Sequencing by Ligation: ABI/SOLiD ""; ""Other Applications of Next-Generation Sequencing Technology ""; ""Clone-Based Approaches to Rearrangement Detection ""; ""ESP ""; ""Third-Generation Sequencing ""

""Proteomic Biomarkers of Malignant Cells """"Monoclonal Antibodies ""; ""Nanobiotechnology-Based Diagnostics and Therapeutics ""; ""Pathogenesis and Cancer Biomarkers ""; ""Pathogenesis ""; ""Chromosomal Instability in Cancer Cells ""; ""Alu-Repeat Elements""; ""Repetitive Sequences in Centromeric Regions ""; ""The Cancer Fragilome ""; ""Sub-Chromosomal Compartments of the Interphase Nucleus of Cancer Cells ""; ""Contribution of the Breakage Fusion Bridge Cycle (BFB) and Telomere Dysfunction to Chromosomal Structural Heterogeneity ""; ""Cellular Events Promoting Genomic Instability ""

""DNA Methylation """"Aberrant DNA Repair Pathways ""; ""Mitotic Segregation Errors ""; ""Metabolic Changes ""; ""Telomerase ""; ""p53 ""; ""Tyrosine Kinase ""; ""Histone Deacetylases (HDACs) ""; ""Biomarkers ""; ""Structural Chromosomal Instability ""; ""Cytogenetic and Cytokinetic Markers ""; ""Epigenetic Biomarker ""; ""Genetic biomarkers ""; ""Single Nucleotide Polymorphism (SNP Genotyping) ""; ""Cells as Biomarkers ""; ""CTC ""; ""T regulatory Cells (CD4+, CD25+and Foxp3+) ""; ""Cancer Stem Cells ""; ""Viral ""; ""Cancer Antigens Based Biomarkers ""

""Prostate Specific Antigen (PSA) """"Cancer Associated Serum Antibodies ""; ""Biomarker Validation ""; ""Clinically Relevant Diagnostics ""; ""Chemical Tests ""; ""Cytogenetic ""; ""Genomic Biomarkers ""; ""Conclusion ""; ""Abbreviations ""; ""References ""; ""Chapter II Evolution of Human Genome Analysis: Impact on Diseases Diagnosis and Molecular Diagnostic Labs ""; ""Abstract ""; ""1. Increased Human Genome Knowledge Through Progress in Sequencing Technology ""; ""2. The Genetic Diagnosis: A Multi Technical Approach for Neurodevelopmental and Metabolic Disorders ""

""2. 1. Mendelian Single Gene Disorders: At the Mutation or Gene Level ""

Notes:

Description based upon print version of record.

Description based on online resource; title from title page (ebrary, viewed August 31, 2013).

Includes bibliographical references at the end of each chapters and index.

ISBN:

1-62808-804-4

OCLC:

867630808