The antibody molecule : from antitoxins to therapeutic antibodies / by Anthony R. Rees.

Format:

Book

Author/Creator:

Rees, Anthony R., author.

Series:

Oxford medical histories.

Oxford Medical Histories

Language:

English

Subjects (All):

Immunoglobulins.

Immunology--History.

Immunology.

Physical Description:

1 online resource (385 p.)

Place of Publication:

Oxford, [England] : Oxford University Press, 2015.

Language Note:

English

Summary:

The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists and biologists alike seeking to unravel the most complex system in the human body outside the brain. This book charts its intriguing history, from the genetic basis of antibody diversity, through theunderstanding of the mechanism by which the immune system's first line of defence works, to breakthroughs in crystallography and the exploitati

Contents:

Cover; The Antibody Molecule; Copyright; Dedication; Contents; Abbreviations; 1 Antibody pre-history: The emergence of empirical immunology; 2 Pre-molecular immunology: The dawn of mechanism; 3 Structural chemistry: Locks, keys, and colloids; 4 The foundations of antibody-antigen recognition emerge; 5 The cellular reformation; 6 The molecular path unfolds; 7 Uncovering the origins of antibody diversity; 8 Immunoglobulin constant regions; 9 Effector functions of constant regions; 10 Transmission and catabolism of IgG; 11 The structural context of antibody diversity

12 Monoclonal antibodies and the mechanisms of hypermutation13 Antibody structure prediction and development of humanization strategies ; 14 Antibody engineering: Improving on natural immunity; 15 Therapeutic antibodies: Case study I: Prevention of respiratory syncytial virus illness; 16 Therapeutic antibodies: Case study II: Targeting breast cancer; 17 Antibodies: The therapeutic future; Author Index; Subject Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

0-19-101616-0

0-19-177518-5

0-19-101615-2

OCLC:

893652967