Frontiers in Drug Design and Discovery.

Format:

Book

Author/Creator:

Atta-ur-Rahman.

Contributor:

Choudhary, M. Iqbal.

Series:

Frontiers in Drug Design and Discovery

Language:

English

Subjects (All):

Drug development.

Drugs--Design.

Drugs.

Physical Description:

1 online resource (261 pages)

Edition:

1st ed.

Other Title:

Frontiers in Drug Design and Discovery

Place of Publication:

Singapore : Bentham Science Publishers, 2021.

Summary:

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field. The tenth volume of this series brings together reviews covering topics related to the treatment of neoplasms, systems biology, respiratory diseases among others. Topics included in this volume are: - Recombinant Protein Production: from Bench to Biopharming - Plant Virus Nanoparticles and Virus like Particles (VLPs): Applications in Medicine - MAO Inhibitory Activity Of 4, 5-Dihydro-1 HPyrazole Derivatives: A Platform To Design Novel Antidepressants - Flavonoids Antagonize Effects of Alcohol in Cultured Hippocampal Neurons: A Drug Discovery Study - Hybrid Smart Materials for Topical Drug Delivery: Application of Scaffolds.

Contents:

Cover

Title

Copyright

End User License Agreement

Content

List of Contributors

Recombinant Protein Production: from Bench to Biopharming

Rais A. Ansari1,*, Shakil A. Saghir2,3, Rebecca Torisky2 and Kazim Husain4

INTRODUCTION

BASIC EXPRESSION CONCEPT

EXPRESSION SYSTEMS

Prokaryotic Expression System

Eukaryotic Expression System

Shuttle Vectors

Yeast Expression System

CHO Expression System

Baculovirus-Mediated Expression

Mammalian Expression

PURIFICATION

BIOPROCESS DEVELOPMENT

BIOPHARMING OF PHARMACEUTICALS

History of Biopharming

A CASE OF HUMAN SERUM ALBUMIN AND HUMAN LACTOFERRIN BIOPHARMING

CONTAMINANTS

CONCLUSIONS

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Plant Virus Nanoparticles and Virus like Particles (VLPs): Applications in Medicine

Mahbobeh Zamani-Babgohari1, Nasir Mahmood1,2, Ghyda Murad Hashim1, Sarah Bushra Nasir3, Mounir G. AbouHaidar1 and Kathleen L. Hefferon1,*

VIRUS LIKE PARTICLES (VLPS)

Types of VLPs

VLPs of Structurally Simple Viruses

VLPs with Lipid Envelope

VLPs with Multiple-Protein Layers

Methods of Production of VLPs

PLANT VIRUS NANOPARTICLES (VNPS)

Classification of Plant Virus Nanoparticles (VNPs)

Filamentous Plant Viruses

Rod-like Plant Virus Nanoparticles

Spherical Plant Viruses

Development of Plant Virus Nanoparticles

APPLICATIONS OF VLPS AND PLANT VNPS FOR IMMUNOTHERAPY

ADVANTAGES OF VLPS AND PLANT VLPS VS. SYNTHETIC NANOPARTICLES IN IMMUNOTHERAPY

CONCLUSION

MAO Inhibitory Activity of 4, 5-Dihydro-1 H-Pyrazole Derivatives: A Platform To Design Novel Antidepressants

Vishnu Nayak Badavath* and Venkatesan Jayaprakash

INTRODUCTION.

Monoamine Oxidases Enzyme and their Mechanism of Action

Monoamine Oxidase Inhibitors (Maois)

Importance of 4, 5-Dihydro-1H-Pyrazoles (Pyrazolines)

MAO INHIBITORY ACTIVITY OF PYRAZOLINES

3-Benzyl-5-Aryl-N1-Phenyl Pyrazoline Derivatives

1, 3, 5-Triaryl Pyrazolines

N1-Acyl-3, 5-Diaryl-Pyrazolines

N1-Thiocarbomoyl-3,5-Diaryl Pyrazolines

N1, 3-Diaryl Pyrazolines

N1-Acetyl-3-Aryl-Pyrazolines

3-Aryl-5-Pyrrolyl-N1-Thiocarbomoyl Pyrazolines

3-Aryl-5-Aryl/Heteoaryl-N1-Guanyl Pyrazoline Derivatives

Hexahydroindazole Containing Pyrazolines

3, 5-Diary Pyrazolines

N1-Thiocarbomoyl-3-Aryl-4-Alkylpyrazoline Derivatives

N1-Arylsulfonyl-3, 5-Diaryl- Pyrazolines

3-Pyrrolyl-5-Aryl-1N-Thiocarbomoyl Pyrazolines

3-Furyl-5-Aryl-N1-Thiocarbomoyl Pyrazolines

3, 5-Diaryl-N1-Carbomoyl Pyrazolines

N-Alky-3,5-Diaryl Pyrazolines

3-Alkyl- 5-Aryl-N1-Carbomoyl Pyrazolines

N1-Ethyl And Phenyl Carbamate Derivatives Of Pyrazoline

Curcumin-Based Pyrazolines Analogues

N1-2-Oxoethyl Benzofuran-2(3H)-One, 5-Dihydro-1H-Pyrazolines

5-(Anthracen-9-Yl)-3-(3-Nitrophenyl)-4,5-Dihydro-1H-Pyrazole

ANTIDEPRESSANT ACTIVITIES OF PYRAZOLINES

3, 5-Diaryl, N1-Benzenesulfonyl Pyrazoline

3, 5-Diaryl Pyrazolines

N1-Acyl-3, 5-Diaryl Pyrazolines

CHIRAL SEPARATION AND COMPUTATIONAL STUDIES OF PYRAZOLINES

SUMMARY AND CONCLUSION

Flavonoids Antagonize Effects of Alcohol in Cultured Hippocampal Neurons: A Drug Discovery Study

Eduard Korkotian1,2,*, Menahem Segal1, Alena Botalova2 and Tatyana Bombela3

EFFECTS OF ALCOHOL IN CULTURED NEURONS: AN OVERVIEW

Acute Effects

Mechanisms of Acute Effect of Ethanol on Excitatory and Inhibitory Neurons.

Calcium-dependent Potassium Channels Mediate Excitatory Effects of Ethanol

Chronic Effects

Molecular Mechanisms of Alcohol-modified Neuronal Activity in Culture

Acute Effects of Ethanol

Acute Effect of Ethanol on GABAA Receptors

Ethanol Acts via SK Channels

Chronic Ethanol AFFECTS Spontaneous Activity in Hippocampal Culture

In vivo Acute and Chronic Experiments

PLANT FLAVONOIDS AND ALCOHOL

Overview

Do Fls Penetrate the Blood-brain Barrier (BBB)?

Effects of Fls on Memory and Cognitive Abilities

Suppression of Neural Inflammations and Alcohol Intoxication by Flavonoids

Flavonoid-mediated Modulation of Neurons via Affecting Signaling Pathways

Common Ways to Treat Alcoholism

Effects of Plant Extracts and Specific Flavonoids on Neuronal Activity: A Screening Study

Extraction and Content of Flavonoids in Melampyrum Sylvaticum and Melampyrum Pratense

Effects of Extracts from Melamphyrum Pratense and their main Active Flavonoids: Hyperoside, Cinaroside and Luteolin on Neuronal Activity

Water Extract from Melamphyrum pratense and Alcohol

Alcohol-related Effects of Acetylpectolinarin from Linaria: In Vivo and In Vitro Studies

Overview of Linaria Mill

Extraction of Acetylpectolinarin (ACP) and the Qualitative Analysis

Anti-alcohol Effect of Acetylpectolinarin In Vivo

Acute and Chronic Effects of Acetylpectolinarin on the Activity of Cultured Hippocampal Neurons

The Ways Flavonoids Eliminate the Effects of Alcohol

ACP Probably Acts via SK Channels

Active Flavonoids of Mp Probably Act via GABAA Channels

Hybrid Smart Materials for Topical Drug Delivery: Application of Scaffolds.

Talita Nascimento1, Henrique de Souza Picciani2, K. Gyselle de Holanda e Silva1 and Thaís Nogueira Barradas2,3,*

TOPICAL DRUG DELIVERY: GENERAL ASPECTS

Topical Formulation Main Aspects

Topical Controlled Drug Delivery

Nanostructured Drug Carriers

POLYMER BASED SCAFFOLDS

Types of Polymer-based Scaffolds

SCAFFOLDS OBTENTION METHODS

Phase Separation Method

Leaching Method

In Situ Polymerization Methods

Electrospinning

Three Dimension (3D) Printing

CHARACTERIZATION

Thermal Analysis (TGA, DSC and DMTA) and Crystallinity Evaluation (XRD)

Microscopy and Microanalysis

HYBRID SCAFFOLDS

SMART SCAFFOLDS

APPLICATIONS OF HYBRID/SMART SCAFFOLDS

Tissue Engineering

Application in Cardiovascular Tissue Engineering

Bone Tissue Engineering Application

Neural Tissue Engineering Application

Topical Drug Delivery

Antitumor Therapy

Wound Healing

Topical Delivery of Proteins, DNA, RNA and Growth Factors

Subject Index

Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9789811421563

9811421560

OCLC:

1241449938