Nanomaterials : evolution and advancement towards therapeutic drug delivery. Part I / edited by Surendra Nimesh, Nidhi Gupta & Ramesh Chandra.

Format:

Book

Author/Creator:

Nimesh, Surendra, Author.

Contributor:

Nimesh, Surendra.

Gupta, Nidhi (Research scientist)

Chandra, Ramesh, 1957-

Language:

English

Subjects (All):

Drug delivery systems.

Nanostructured materials.

Physical Description:

1 online resource (299 pages)

Edition:

1st ed.

Place of Publication:

Sharjah : Bentham Science Publishers, 2021.

Summary:

The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage by enhancing aqueous solubility that leads to improved bioavailability, increased resistance time in the body, decreased side effects by targeting drugs to the specific location, reduced dose dependent toxicity and protection of drugs from early release. In this volume, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers, that can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies. The book is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.

Contents:

Cover

Title

Copyright

Contents

Foreword

Preface

List of Contributors

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery Applications

Gabriel Silva Borges1, Mariana Silva Oliveira1, De´lia Chaves Moreira dos Santos1, Lucas Anto^nio Miranda Ferreira1 and Guilherme Carneiro2,*

INTRODUCTION

BACKGROUND

COMPOSITION OF SLN AND NLC

Lipids

Surfactants

Other Components

METHODS FOR SLN AND NLC PRODUCTION

Hot or Cold Homogenization Technique

High Pressure Homogenization (HPH)

Ultrasonication

O/W Microemulsion Emulsification-Solvent Evaporation

Solvent Injection Method

Multiple Emulsion

Membrane Contactor Method

Super Critical Fluid Technique

Drug Distribution in Lipid Nanocarriers

Strategies for Improving Encapsulation of Drugs in Lipid Nanoparticles

PHYSICOCHEMICAL CHARACTERIZATION

Particle Size

Dynamic Light Scattering

Laser Diffraction

Scanning Ion Occlusion Spectroscopy

Zeta Potential

Crystallinity and Polymorphism

Differential Scanning Calorimetry

X-ray Diffraction

Particle Shape and Morphology

Drug Encapsulation Efficiency and Drug Loading Soluble in Aqueous Medium

Precipitated

Total Drug Concentration

COMMON PROBLEMS IN SLN AND NLC

Gelation

Supercooled Melts

Coexistence of Nanostructures

MAIN APPLICATIONS OF SLN AND NLC IN PHARMACEUTICS

Administration Routes

Dermal Route

Oral Route

Pulmonary Route

Intravenous Administration

Intranasal Delivery

Ophthalmic Delivery

Important Applications of SLN and NLC

Cancer

Brain Delivery

CONCLUSION

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Silica Based Nanomaterial for Drug Delivery Charu Bharti1, Md. Sabir Alam2, Md. Noushad Javed3, Muhammed Khalid Saifullah4, Faisal A. Almalki4 and Romila Manchanda5,*

CHEMISTRY OF MESOPOROUS SILICA NANOPARTICLES

CHARACTERISTICS OF MSNS

CHARACTERIZATION TECHNIQUES USED FOR MSNS

FT-IR Spectra

Electron Microscopy

METHODS OF PREPARATION OF MSNS

Stober Process

Evaporation Induced Assembly Synthesis

Combustion Synthesis Process

Aerosol Decomposition Synthesis

Chemical Vapour Deposition

Photothermal Synthesis

Inert Gas Condensation SURFACE FUNCTIONALIZATION OF SILICA NANOPARTICLES BY VARIOUS METHODS

Co-condensation Method

Post-synthetic Grafting

BIOCOMPATIBILITY AND BIO-DISTRIBUTION

Impact of Size and Shape of the Particle

Impact of Surface Properties

APPLICATIONS OF MSNS

MSNs as siRNA Delivery Vehicles for Cancer Therapy

Gene Delivery / Drug Delivery Using MSNs

Bio-medical Imaging

The Imaging Capability of MSNs in Biomedical

Controlled Release of Bioactive Molecules

Green Chemistry Application of MSNs

Protein Adsorption and Separation

Vascular Targeting/ Passive Targeting.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9781681087818

1681087812

OCLC:

1257084331