Optogenetics / Peter Hegemann, Stephan Sigrist.

Format:

Book

Contributor:

Hegemann, Peter, editor.

Sigrist, Stephan, editor.

Series:

Dahlem Workshop Reports

Language:

English

Subjects (All):

Electrooptical devices.

Neural networks (Neurobiology).

Neural transmission.

Physiological optics.

Physical Description:

1 online resource (240 p.)

Place of Publication:

Berlin ; Boston : De Gruyter, [2013]

Language Note:

English

Summary:

Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and

Contents:

Frontmatter

Content

Introduction

1 The biophysics and engineering of signaling photoreceptors / Moffat, Keith / Zhang, Feng / Hahn, Klaus / Möglich, Andreas

2 Current challenges in optogenetics / Zalocusky, Kelly A. / Fenno, Lief E. / Deisseroth, Karl

3 Challenges and opportunities for optochemical genetics / Isacoff, Ehud Y. / Kramer, Richard H. / Trauner, Dirk

4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives / Knöpfel, Thomas

5 Why optogenetic "control" is not (yet) control / Miesenböck, Gero

6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans / Bono, Mario de / Schafer, William R. / Gottschalk, Alexander

7 Putting genetics into optogenetics: knocking out proteins with light / Labella, Matt L. / Sigrist, Stephan / Jørgensen, Erik M.

8 Optogenetic approaches in behavioral neuroscience / Fiala, André

9 Combining genetic targeting and optical stimulation for circuit dissection in the zebrafish nervous system / Kubo, Fumi / Baier, Herwig

10 Optogenetic analysis of mammalian neural circuits / Oertner, Thomas G. / Helmchen, Fritjof / Lecea, Luis de / Beck, Heinz / Konnerth, Arthur / Kaupp, Benjamin / Knöpfel, Thomas / Yawo, Hiromu / Häusser, Michael

11 Optogenetics to benefit human health: opportunities and challenges / Gradinaru, Viviana

12 Optogenetic tools for controlling neural activity: molecules and hardware / Boyden, Edward S.

13 In vivo application of optogenetics in rodents / Eban-Rothschild, Ada / Touriño, Clara / Lecea, Luis de

14 Potential of optogenetics in deep brain stimulation / Sturm, V.

15 Optogenetic approaches for vision restoration / Pan, Zhuo-Hua / Roska, Botond / Sahel, José-Alain

16 Restoration of vision - the various approaches / Zrenner, Eberhart / Lorenz, Birgit

17 Optogenetic approaches to cochlear prosthetics for hearing restoration / Moser, Tobias

18 History in the making: the ethics of optogenetics / Schleiermacher, Sabine

19 Optogenetics as a new therapeutic tool in medicine? A view from the principles of biomedical ethics / Walter, Henrik / Müller, Sabine

Appendix

Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

CC BY-NC-ND

Description based on online resource; title from PDF title page (publisher's Web site, viewed 08. Jul 2019)

ISBN:

9783110270723

3110270722

OCLC:

858761864