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DNA damage repair, repair mechanisms and aging / Allison E. Thomas, editor.
- Format:
- Book
- Series:
- DNA--properties and modifications, functions and interactions, recombination and applications series.
- DNA--properties and modifications, functions and interactions, recombination and applications
- Language:
- English
- Subjects (All):
- DNA repair.
- Physical Description:
- 1 online resource (304 p.)
- Place of Publication:
- New York : Nova Science Publishers, Inc., c2010.
- Language Note:
- English
- Summary:
- The preservation of expected life span and longevity, as well as the assurance of life succession among all species requires the integrity and faithful transcription of DNA. A dedicated machinery of DNA repair factors is responsible for reversing DNA damage across the genome. Efficient response to various effectors of DNA damage is also dependent on a complex network of sensors and mediators of stress signals which are upstream of DNA repair activation and together constitute components of the DNA damage response (DDR). This book reviews research on cell cycle checkpoints as essential mechanisms for safeguarding genome stability; nucleotide excision repair (NER) which recognizes and removes bulky DNA damage that leads to DNA double-helix distortion and others.
- Contents:
- DNA instability in premature aging / Lynne S. Cox, Ivan Boubriak
- Recent advances on DNA damage, its repair, and genomic stability of green algae Chlamydomonas reinhardtii and other photoautotrophic eukaryotes / Andrea Sevcovicova, Alena Hercegova
- Intra s-phase checkpoint / Deborah Ruth Tasat, J. Sebastian Yakisich
- Multiplex cell free assays to apprehend DNA repair responses : application to aging study / Sylvie Sauvaigo ... [et al.]
- 8-dihydro-8-oxoguanine, a major form of oxidative DNA damage, and its repair system / Takeshi Hirano
- Participation of heat shock proteins in DNA repair mechanisms in cancer / Silvina Nadin, Daniel R. Ciocca
- DNA damage repair in testicular germ cells of aging men / Moetaz El-Domyati, Hasan El-Fakahany, Denny Sakkas
- Nucleotide-excision repair deficiency : a causative factor for accelerated aging diseases in humans? / Ming Yin, Qingyi Wei
- Historical development of uncaria preparations and their related bioactive components / Ronald W. Pero
- DNA damage response and repair : mechanisms in aging and cancer / Panagiotis J. Vlachostergios, Ioannis A. Voutsadakis
- DNA repair gene XPC codon 939 polymorphism and AFB1-related hepatocellular carcinoma risk in Guangxi population, China / Xi Dai Long
- Influence of age on expresion of DNA repair genes in Arabidopsis / Megan J. Osmond, Bernard A. Kunz.
- Notes:
- "Nova biomedical."
- Includes bibliographical references and index.
- ISBN:
- 1-61728-055-0
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