Oligodendrogliomas (ODs) : diagnosis, outcomes and prognosis / Chad Reeves, editor.

Format:

Book

Contributor:

Reeves, Chad, editor.

Series:

Cancer etiology, diagnosis, and treatments.

Cancer Etiology, Diagnosis and Treatments

Language:

English

Subjects (All):

Nervous system--Tumors.

Nervous system.

Oligodendroglia.

Gliomas.

Physical Description:

1 online resource (158 p.)

Place of Publication:

New York : Nova Science Publishers, Inc., 2016.

Summary:

Cancer is the second leading cause of morbidity and mortality worldwide, ranking just after cardiovascular diseases. In the central nervous system, gliomas constitute the most frequent type of tumors. According to the definition, oligodendrogliomas are diffusely infiltrating glial tumors, composed of neoplastic oligodendroglial cells, typically found in cerebral hemispheres in adult population, although not uncommon in children. They encompass a range of tumours, from well-differentiated to frankly malignant neoplasms. In the current World Health Organization (WHO) classification of tumors of the central nervous system, covering a four-tiered WHO grading scheme, oligodendrogliomas are recognised as grade WHO II and WHO III by the degree of malignancy. They may be either well differentiated, composed of neoplastic cells that morphologically resemble oligodendroglia, or may harbor focal or diffuse features of malignancy, respectively. Their prognosis is in this case less favorable. This book provides current research on the diagnosis, outcomes and prognosis of oligodendrogliomas. Chapter one examines the pathology, molecular mechanisms and clinical references of ODs. Chapter two discusses the ODs and the problematic diagnostic markers. Chapter three examines the histopathologic features of oligodendrogliomas and of an assortment of other central nervous system neoplasms that can resemble them and reviews features that allow one to sort through these histopathologic differential diagnoses. The final chapter reviews speech mapping in oligodendroglioma operations and provides data regarding patient outcomes with these methods.

Contents:

OLIGODENDROGLIOMAS (ODS) DIAGNOSIS, OUTCOMES AND PROGNOSIS ; OLIGODENDROGLIOMAS (ODS) DIAGNOSIS, OUTCOMES AND PROGNOSIS ; CONTENTS ; PREFACE ; Chapter 1 PATHOLOGY, MOLECULAR MECHANISMS AND CLINICAL REFERENCES OF OLIGODENDROGLIOMAS ; ABSTRACT; 1. INTRODUCTION; 1.1. The Origin of Oligodendroglioma; 1.2. Epidemiology; 1.3. Clinical Features; 1.4. Neuroradiological Features; 2. PATHOLOGY ; 2.1. Macroscopic Appearance ; 2.2. Microscopic Appearance ; OII ; OIII ; OAII ; OAIII; GBMO; 2.3. Microglia/Macrophages ; 2.4. Differential Diagnosis and Prognosis

3. MOLECULAR GENETICS WITH REFERENCE TO DIFFERENTIAL DIAGNOSIS AND PROGNOSIS 3.1. 1p/19q Chromosomal Status ; 3.2. Mechanism of the Combined Loss of Chromosomes 1p and 19q ; 3.3. Methods for the Detection of 1p/19q Chromosomal Status ; 3.4. Candidate Tumor Suppressor Genes (TSGs) on 1p and 19q ; 3.5. IDH1/2 Mutations ; 3.6. Telomerase Reverse Transcriptase (TERT) Promoter Mutations ; 3.7. ATRX Mutations ; 3.8. CIC and FUBP1 Mutations ; 3.9. O6-Methylguanine-DNA Methyltransferase (MGMT) Promoter Hypermethylation and G-CIMP ; 3.10. Epithelial Membrane Protein 3 (EMP3)

3.11. Anaplastic Oligodendroglioma 3.12. Pediatric Oligodendroglioma ; 3.13. GBMO ; 3.14. Timing and Relationships with Gliomagenesis ; 4. MICRORNAS (MIRNAS) ; 5. TREATMENT ; 6. PROGNOSIS ; CONCLUSION; ACKNOWLEDGMENT ; REFERENCES ; Chapter 2 MOLECULAR MARKERS OF OLIGODENDROGLIOMAS ; ABSTRACT ; INTRODUCTION ; EPIDEMIOLOGY AND AETIOLOGY ; TUMOUR SIGNS AND SYMPTOMS ; TREATMENT OF OLIGODENDROGLIAL TUMOURS ; HISTOPATHOLOGY AND NEUROONCOLOGY ; THE IMPORTANCE OF MOLECULAR MARKERS ; Chromosomes 1 and 19 and the Prognostic and Diagnostic Value of 1p and 19q Abnormalities ; MGMT Mutation

Hypermethylation Mutations in p53Gene ; Growth Factors and Other Genetic Abnormalities ; CONCLUSION; REFERENCES; Chapter 3 OLIGODENDROGLIOMA LOOK-ALIKES: THE HISTOPATHOLOGIC DIFFERENTIAL DIAGNOSIS ; ABSTRACT ; INTRODUCTION ; WHAT DOES OLIGODENDROGLIOMA LOOK LIKE? ; DIFFUSE ASTROCYTOMA VERSUS OLIGODENDROGLIOMA ; OLIGOASTROCYTOMA/MIXED GLIOMA VERSUS OLIGODENDROGLIOMA ; PILOCYTIC ASTROCYTOMA VERSUS OLIGODENDROGLIOMA ; PAPILLARY GLIONEURONAL TUMOR VERSUS OLIGODENDROGLIOMA; DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMOR VERSUS OLIGODENDROGLIOMA ; GANGLIOGLIOMA VERSUS OLIGODENDROGLIOMA

CENTRAL NEUROCYTOMA VERSUS OLIGODENDROGLIOMA CLEAR CELL EPENDYMOMA VERSUS OLIGODENDROGLIOMA ; ROSETTE-FORMING GLIONEURONAL TUMOR OF THE FOURTH VENTRICLE VERSUS OLIGODENDROGLIOMA ; INFLAMMATORY-RELATED LESIONS VERSUS OLIGODENDROGLIOMAS ; CONCLUSION; REFERENCES ; Chapter 4 LESSONS LEARNED FROM AWAKE BRAIN FUNCTION MAPPING IN AGGRESSIVE MULTIMODAL RESECTION OF OLIGODENDROGLIOMAS ; ABSTRACT ; INTRODUCTION; ROLE FOR SURGERY ; ONCOFUNCTIONAL BALANCE ; MAPPING; ANATOMO-FUNCTIONAL VARIABILITY ; PLASTICITY; SELECTED CASES ; ALTERNATIVES TO INTRA-OPERATIVE MAPPING ; SURGICAL ADJUVANTS

CONCLUSION

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed September 4, 2016).

ISBN:

1-63484-279-0