Quality control and safety evaluation of natural products / Shuang-Qing Zhang [and three others], editors.

Format:

Book

Contributor:

Zhang, Shuang-Qing, editor.

Series:

Public health in the 21st century series.

Public Health in the 21st Century

Language:

English

Subjects (All):

Natural products--Testing.

Natural products.

Physical Description:

1 online resource (254 p.)

Place of Publication:

New York, [New York] : Nova Publishers, 2016.

Summary:

Natural medicines are derived from natural sources such as plants, animals and/or mineral origins. The use of traditional natural products is an empirical healthcare system based on thousands of years of human experience. Over the past few decades, quality control and safety evaluation methods for natural products, though sophisticated and technologically advanced, still lack comprehensiveness and practicability to some extent. Generally, those methods fully satisfy the modern scientific requirements for extraction, identification, purity, quality and pharmacological effects in the assessment of chemical drugs. However, they are not suitable for handling the complex chemical characteristics of natural products. Therefore, a better understanding of the basic properties of natural medicines and advanced chemical, pharmacological and biological techniques would facilitate the application of the natural products in public health. The purpose of this book is to address the issues mentioned above and present related solutions. The book covers the below topics: *Advanced analytical technologies in the application of the natural medicines (e.g. mass spectrometry, gas or liquid chromatography, and NMR). *Recent advances in biochemistry research of natural medicines (e.g. gene expression microarray, tissue microarray, and chromatin-precipitation assay) *Innovations in analytical chemistry of natural products *Quality control and safety evaluation of traditional medical material and finished products *Detection of low quality and adulterants of natural product *Identification of the plant by various analytical techniques *Regulations and management of natural products from foreign countries *Novel cell-based models used for the high-throughput screening for drug discovery in natural products *Pharmacological effects of natural products in vitro and in vivo *Advanced modeling techniques used in pharamcokinetic and pharmacodynamic properties of natural products (e.g. Pharsight WINNONLIN, Simcyp, and Gastroplus)

Contents:

QUALITY CONTROL AND SAFETY EVALUATION OF NATURAL PRODUCTS ; QUALITY CONTROL AND SAFETY EVALUATION OF NATURAL PRODUCTS ; Library of Congress Cataloging-in-Publication Data; CONTENTS ; PREFACE ; Chapter 1 A REVIEW ON THE APPLICATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY IN THE QUALITY CONTROL OF TRADITIONAL CHINESE MEDICINES ; 1. INTRODUCTION ; 2. IDENTIFICATION AND DETERMINATION OF CHEMICAL CONSTITUENTS OF TCM BY LC-MS ; 3. DISCRIMINATION OF DIFFERENT GEOGRAPHICAL ORIGIN OF TCM BY LC-MS COMBINED WITH CHEMOMETRICS

4. DISCRIMINATION OF TRADITIONAL CHINESE MEDICINAL MATERIALS ANDRELEVANT MEDICINAL SLICES BY LC-MS 5. DISCRIMINATION OF DIFFERENT SPECIES OF TRADITIONAL CHINESE MEDICINAL MATERIALS BY LC-MS ; 6. EXPLORING CHEMICAL CHANGES OF TRADITIONAL CHINESE MEDICINES DURING SULFER-FUNIGATIONG BY LC-MS; 7. DETECTION OF SYNTHETIC CHEMICALS ILLEGALLY ADDED INTO TCM WITH BY LC-MS; CONCLUSION; REFERENCES ; Chapter 2 THE APPLICATION OF DNA MOLECULAR TECHNIQUES IN IDENTIFICATION OF TRADITIONAL CHINESE MEDICINE ; 1. INTRODUCTION

2. GENERAL CLASSIFICATIONS AND THEORIES OF DNA MOLECULAR IDENTIFICATION METHODS 2.1. PCR-Related Methods Coupled with Agarose Gel Electrophoresis; 2.2. Real-Time Quantitative PCR (RT-qPCR) ; 2.3. DNA Barcoding ; 3. APPLICATIONS ; 3.1. The Identification of Fritillariae Cirrhosae Bulbus with PCR-RFLP Method ; 3.2. The Identification of Bungarus Parvus with the Method of DNA Sequence Based-Specific Primer Designed PCR ; 3.3. The Application of Real-Time PCR in Identification of Gentiana Macrophylla (Qin-Jiu) and Asini Corii Colla (E'jiao) ; 3.3.1. Gentiana Macrophylla

3.3.2. Asini Corii Colla (E'jiao) 3.4. The Application of DNA Barcoding in the Identification of Cordyceps sinensis ; CONCLUSION ; REFERENCES ; Chapter 3 PHYTOCHEMICALS FROM HONEY: A REVIEW FOR THE ROLES IN FLORAL IDENTIFICATION AND AUTHENTIFICATION ; 1. INTRODUCTION ; 2. PHYTOCHEMICAL PROFILES IN UNIFLORAL HONEYS ; 2.1. Volatile Compounds ; 1.2. Phenolic Compounds ; 1.2.1. Flavonoids Profiles in Honeys ; 1.2.2. Phenolics Profiles in Honeys ; 1.3. Alkaloids ; 2. QUALITY CONTROL ; 2.1. Introduction to Quality Control of Honeys

2.2. Foodomics Applied to the Evaluation of Botanical Origin of Honeys Example 1; Example 2 ; ACKNOWLEDGMENTS ; REFERENCES ; Chapter 4 IMPLEMENTATION AND PRACTICE OF SAFETY EVALUATION OF NATURAL PRODUCTS ; 1. INTRODUCTION ; 2. ALKALOIDS ; 2.1. Colchicine ; 2.1.1. Hepatotoxicity; 2.1.2. Genotoxicity ; 2.1.3. Neurotoxicity; 2.1.4. Clinical ; 2.2. Scopolamine ; 3. TERPENOIDS ; 3.1. Artemisinin ; 3.1.1. Neurotoxicity and Cardiotoxicity; 3.1.2. Embryotoxicity; 3.1.3. Genotoxicity ; 3.1.4. Hematotoxicity ; 3.2. Paclitaxel ; 4. PHENOLS AND COUMARINS ; 4.1. Tea Catechins ; 4.2. Honokiol

4.3. Proanthocyanidin

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-63484-524-2