Spermatogenesis : molecular mechanisms, regulation and biological perspectives / Gladys Robinson, editor.

Format:

Book

Contributor:

Robinson, Gladys, editor.

Series:

Human reproductive system--anatomy, roles, and disorders series.

Human Reproductive System - Anatomy, Roles and Disorders

Language:

English

Subjects (All):

Spermatogenesis.

Physical Description:

1 online resource (119 p.)

Place of Publication:

New York : Nova Biomedical, 2016.

Summary:

Spermatogenesis is a tightly regulated cellular renovation and differentiation process. It consists of self-renewal and differentiation of spermatogonial stem cells (SSCs), spermatocytic meiosis and spermiogenesis; each of these processes is essential to the continuous, successful production of male gametes. During spermiogenesis, haploid spermatids undergo extensive cellular, molecular and morphological changes, including acrosome biogenesis, flagellum development, cytoplasmic reorganization and chromatin condensation. These changes ultimately result in mature spermatozoa with an acrosome-covered head and motile tail. In this book, Chapter One summarizes the progress that has been made in understanding the molecular mechanisms underlying acrosome biogenesis, and the authors discuss the potential directions of future investigations of this process. Chapter Two briefly addresses the basics of spermatogenesis and the synthesis of ncRNAs, and then the authors discuss the recent progress in understanding of the functions of miRNAs, endo-siRNAs, piRNAs and lncRNAs in the regulation of spermatogenesis. Chapter Three provides a review of the current literature on testicular immunoregulation and its underlying mechanisms, along with its effect on testicular functions.

Contents:

SPERMATOGENESIS MOLECULAR MECHANISMS, REGULATION AND BIOLOGICAL PERSPECTIVES ; SPERMATOGENESIS MOLECULAR MECHANISMS, REGULATION AND BIOLOGICAL PERSPECTIVES ; Library of Congress Cataloging-in-Publication Data; CONTENTS ; PREFACE ; Chapter 1 THE MOLECULAR MECHANISMS UNDERLYING ACROSOME BIOGENESIS ; ABSTRACT ; INTRODUCTION ; 1. ACROSOMAL PROTEIN SYNTHESIS AND MODIFICATION; 2. THE VESICULAR TRAFFICKING OF ACROSOMAL GRANULES DURING ACROSOME BIOGENESIS ; 2.1. ER-Golgi-Acrosome Vesicular Trafficking ; 2.1.1. Acrosomal Protein Transport from the ER to the Golgi

2.1.2. Golgi-Derived Vesicular Trafficking2.2. Endocytic Vesicular Trafficking; 2.3. Cytoskeletal Transportation during Acrosome Biogenesis ; 3. THE ANCHORING OF THE ACROSOME TO THE NUCLEUS ; 4. THE MORPHOGENESIS OF THE ACROSOME ; 5. THE ACROSOME, MODIFIED LYSOSOME OR AUTOLYSOSOME? ; CONCLUSION AND FUTURE PERSPECTIVES ; REFERENCES ; BIOGRAPHICAL SKETCH ; Chapter 2 REGULATORY ROLE OF NONCODING RNAS DURING SPERMATOGENESIS ; ABSTRACT ; INTRODUCTION ; MICRORNAS IN SPERMATOGENESIS ; miRNAs Biogenesis ; Function of miRNAs in Spermatogenesis

ENDOGENOUS SMALL-INTERFERING RNAS IN SPERMATOGENESIS Endo-siRNAs Biogenesis ; Function of Endo-siRNAs in Spermatogenesis ; PIWI-INTERACTING RNAS IN SPERMATOGENESIS; piRNA and PIWI Machinery ; Prepachytene piRNAs ; Pachytene piRNAs ; piRNA Biogenesis ; piRNA Function in Spermatogenesis ; Silence of Transposons and Maintenance of Genome Integrity ; Degradation of RNAs ; Genomic Imprinting ; Regulation of mRNA Translation ; Proteins Associated with PIWI/piRNA Machinery ; LONG NONCODING RNAS IN SPERMATOGENESIS ; Classification of lncRNAs ; Mechanistic Models of lncRNAs

lncRNA Profiling in Testis and Male Germ Cells Functional lncRNAs in Spermatogenesis ; Meiotic Recombination Hot Spot Locus (Mrhl) ; HongrES2; Testis-Specific X-Linked (Tsx) ; Dmrt1-Related Gene (Dmr) ; Spermatogonial-Specific lncRNAs (spga-lncRNAs) ; Narcolepsy Candidate-Region 1 Gene (NLC1-C) ; CONCLUSION ; ACKNOWLEDGMENTS ; REFERENCES ; Chapter 3 TESTICULAR IMMUNE ENVIRONMENT FOR SPERMATOGENESIS; ABSTRACT ; INTRODUCTION ; 1. IMMUNE PRIVILEGE IN THE TESTIS ; 1.1. Historical Misconception of Testicular Immune Privilege ; 1.2. Local Immunosuppressive Milieu within the Testis

1.3. Negative Immunoregulatory Systems1.4. Peripheral Immune Tolerance to Male Germ Cell Antigens ; 2. RESIDENT LEUKOCYTES IN THE TESTIS ; 2.1. Macrophages ; 2.2. Lymphocytes ; 2.3. Mast Cells ; 2.4. Dendritic Cells (DCs) ; 3. IMMUNE CYTOKINES ; 3.1. Pro-Inflammatory Cytokines ; 3.2. Chemokines ; 4. INNATE IMMUNE RESPONSES IN TESTICULAR CELLS ; 4.1. PRR-Initiated Innate Immune Responses ; 4.2. TLRs in Testicular Cells ; 4.3. RLR-Initiated Antiviral Response in the Testis ; 4.4. Cytosolic DNA Sensors in Leydig Cells ; 5. ORCHITIS ; 5.1. Infectious Orchitis ; 5.2. Autoimmune Orchitis

CONCLUSION

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-63484-726-1