Diffuse Large B-Cell Lymphoma (DLBCL) : symptoms, treatment and prognosis / Haipeng Shao, Editor.

Format:

Book

Contributor:

Shao, Haipeng, editor.

Series:

Cancer etiology, diagnosis, and treatments.

Cancer Etiology, Diagnosis and Treatments

Language:

English

Subjects (All):

Lymphomas.

Physical Description:

1 online resource (196 p.)

Place of Publication:

[Hauppauge, New York] : Nova, 2016.

Summary:

The diagnosis and treatment of Diffuse large B-cell lymphoma (DLBCL) have evolved significantly in the past decade. With advances in our understanding of DLBCL through the application of immunophenotypic, molecular cytogenetic analysis and clinical correlation, a growing number of discrete subtypes and entities of DLBCL have been recognized, along with improved prognostic stratification and treatment strategies. A simple diagnosis of DLBCL and standard chemotherapy are no longer appropriate for every individual patient anymore. Pathologists and practicing clinicians need to be familiar with current literature in order to achieve the best treatment of their patients. This book aims to provide the most up-to-date knowledge of the diagnosis, prognosis and treatment strategies of DLBCL. Each chapter focuses on a different subject of DLBCL: pathology, prognosis, chemotherapy regimens and future directions, role of radiation therapy and hematopoietic stem cell transplant, and treatment strategies, as well as special considerations in the treatment of the most common subtypes of DLBCL. The authors are practicing physicians in major medical centers and university hospitals, and are familiar with the challenges of diagnosing and treating patients with DLBCL. The book is written for practicing physicians and provides practical information and advice for their daily practice. Residents, fellows and physicians in their early career development will also find the contents of this book useful for their education and board preparation. The authors hope that the material covered in this book will serve as a foundation for readers to keep up with future developments in this specific field of study.

Contents:

DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) SYMPTOMS, TREATMENT AND PROGNOSIS ; DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) SYMPTOMS, TREATMENT AND PROGNOSIS ; Library of Congress Cataloging-in-Publication Data; CONTENTS ; PREFACE ; Chapter 1 Pathologic Diagnosis and Prognostic Markers of Diffuse Large B-Cell Lymphoma; Abstract; Introduction; Epidemiology and Clinical Features; Morphologic and Immunophenotypic Features; Differential Diagnosis; Genetic and Molecular Features; Prognostic Markers; Morphologic Subtypes and Other Entities; T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

Primary DLBCL of the Central Nervous SystemPrimary Cutaneous DLBCL, Leg Type; EBV-Positive DLBCL of the Elderly; Primary Mediastinal (Thymic) Large B-Cell Lymphoma; Intravascular Large B-Cell Lymphoma; Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation; Lymphomatoid Granulomatosis; ALK-Positive Large B-Cell Lymphoma; Plasmablastic Lymphoma; Diffuse Large B-Cell Lymphoma with IG/IRF4 Translocation; Large B-Cell Lymphoma Arising in HHV8-Associated Multicentric Castleman Disease; Primary Effusion Lymphoma

B-Cell Lymphoma, Unclassifiable, with Features Intermediate between DLBCL and Classical Hodgkin LymphomaB-Cell Lymphoma, Unclassifiable, with Features Intermediate between DLBCL and Burkitt Lymphoma; References; Chapter 2 Diffuse Large B-Cell Lymphoma: Diagnosis, Treatment and Prognosis; Abstract; Introduction; Clinical Presentation of DLBCL; Prognosis of DLBCL; Pathologic Characteristics and Classification of DLBCL; DLBCL, Not Otherwise Specified (NOS); Primary Mediastinal Large B-Cell Lymphoma (PMBCL); T-Cell/Histiocyte-Rich Large B-Cell Lymphoma; EBV-Positive DLBCL

DLBCL in Specific Anatomic SitesDLBCL with Plasma Cell Immunophenotype; B-Cell Lymphoma, Unclassifiable, with Features Intermediate between DLBCL and Burkitt Lymphoma; B-Cell Lymphoma, Unclassifiable, with Features Intermediate between DLBCL and Hodgkin Lymphoma; Treatment of DLBCL; Current Standard of Care: Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone (R-CHOP); Treatment of Older Adults; Treatment of Patients with Cardiac Dysfunction; HIV-Associated Lymphomas; Primary Mediastinal Large B-Cell Lymphoma; Relapsed/Refractory DLBCL

Future Directions in the Treatment of DLBCLTargeted Therapies for Surface Markers in DLBCL; Targeted Therapies for GCB-Type DLBCL; Targeted therapies for ABC-Type DLBCL; Chimeric Antigen Receptor T (CAR T)-Cell Therapy; Conclusion; References; Chapter 3 The Evolving Role of Radiation Therapy in the Management of Diffuse Large B-Cell Lymphoma; Abstract; Introduction; The Era of Chop; Prospective Trials; Retrospective Studies; R-CHOP Studies; Advanced Stage; Prospective Evaluation in the Era of R-CHOP; Radiation Techniques; Risk-Adapted Treatment Selection; Conclusion; References

Chapter 4 Autologous and Allogeneic Hematopoietic Stem Cell Transplantation for Diffuse Large B-Cell Lymphoma

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed September 2, 2016).

ISBN:

1-63484-417-3